The Functional Role of Sphingosine Kinase 2
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683767/full |
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| author | Rocio Diaz Escarcega Louise D. McCullough Louise D. McCullough Andrey S. Tsvetkov Andrey S. Tsvetkov Andrey S. Tsvetkov |
| author_facet | Rocio Diaz Escarcega Louise D. McCullough Louise D. McCullough Andrey S. Tsvetkov Andrey S. Tsvetkov Andrey S. Tsvetkov |
| author_sort | Rocio Diaz Escarcega |
| collection | DOAJ |
| description | Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial respiration, among many other processes. SPHK2 is under investigation as a target for treating many age-associated conditions, such as cancer, stroke, and neurodegeneration. In this review, we will focus on the role of SPHK2 in health and disease. |
| first_indexed | 2024-12-21T10:43:40Z |
| format | Article |
| id | doaj.art-ae4524f9bdc848e7a4c9f1deba045b07 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-21T10:43:40Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-ae4524f9bdc848e7a4c9f1deba045b072022-12-21T19:06:51ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-05-01810.3389/fmolb.2021.683767683767The Functional Role of Sphingosine Kinase 2Rocio Diaz Escarcega0Louise D. McCullough1Louise D. McCullough2Andrey S. Tsvetkov3Andrey S. Tsvetkov4Andrey S. Tsvetkov5Department of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, United StatesDepartment of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, United StatesThe University of Texas Graduate School of Biomedical Sciences, Houston, TX, United StatesDepartment of Neurology, The University of Texas McGovern Medical School at Houston, Houston, TX, United StatesThe University of Texas Graduate School of Biomedical Sciences, Houston, TX, United StatesUTHealth Consortium on Aging, The University of Texas McGovern Medical School, Houston, TX, United StatesSphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and sphingosine kinase 2 (SPHK2), synthesize S1P by phosphorylating sphingosine. While SPHK1 is a cytoplasmic kinase, SPHK2 is localized to the nucleus, endoplasmic reticulum, and mitochondria. The SPHK2/S1P pathway regulates transcription, telomere maintenance, mitochondrial respiration, among many other processes. SPHK2 is under investigation as a target for treating many age-associated conditions, such as cancer, stroke, and neurodegeneration. In this review, we will focus on the role of SPHK2 in health and disease.https://www.frontiersin.org/articles/10.3389/fmolb.2021.683767/fullsphingolipidssphingosine-1-phosphatesphingosine kinase 2nuclear lipidsaging |
| spellingShingle | Rocio Diaz Escarcega Louise D. McCullough Louise D. McCullough Andrey S. Tsvetkov Andrey S. Tsvetkov Andrey S. Tsvetkov The Functional Role of Sphingosine Kinase 2 Frontiers in Molecular Biosciences sphingolipids sphingosine-1-phosphate sphingosine kinase 2 nuclear lipids aging |
| title | The Functional Role of Sphingosine Kinase 2 |
| title_full | The Functional Role of Sphingosine Kinase 2 |
| title_fullStr | The Functional Role of Sphingosine Kinase 2 |
| title_full_unstemmed | The Functional Role of Sphingosine Kinase 2 |
| title_short | The Functional Role of Sphingosine Kinase 2 |
| title_sort | functional role of sphingosine kinase 2 |
| topic | sphingolipids sphingosine-1-phosphate sphingosine kinase 2 nuclear lipids aging |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.683767/full |
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