Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature
Introduction Neuroimaging has been a highly utilized technique for studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) independently of one another, however, neuroimaging has increasingly been identified as a useful tool in better understanding TBI-related psychiatric co...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822011981/type/journal_article |
| _version_ | 1797616951752654848 |
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| author | A. Esagoff D. Stevens M. Bray B. Bryant N. Daneshvari D. Jung C. Rodriguez L. Richey L. Luna H. Sair M. Peters |
| author_facet | A. Esagoff D. Stevens M. Bray B. Bryant N. Daneshvari D. Jung C. Rodriguez L. Richey L. Luna H. Sair M. Peters |
| author_sort | A. Esagoff |
| collection | DOAJ |
| description |
Introduction
Neuroimaging has been a highly utilized technique for studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) independently of one another, however, neuroimaging has increasingly been identified as a useful tool in better understanding TBI-related psychiatric conditions, such as PTSD.
Objectives
To complete a systematic review of the literature examining neuroimaging findings in TBI-related PTSD and to highlight the current literature’s limitations in order to strengthen future research.
Methods
A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases prior to May of 2019. The initial database query yielded 4388 unique articles, which were narrowed down based on specified inclusion criteria (e.g., clear TBI definition, clinician-diagnosed PTSD, statistically analyzed relationship between neuroimaging and PTSD, quantified time interval between TBI and neuroimaging).
Results
A final cohort of 10 articles met inclusion criteria, comprising the findings of 482 participants with TBI. Key neuroanatomical findings among the included articles suggest that PTSD is associated with significant changes in whole-brain networks of resting state connectivity and disruptions in bilateral frontal and temporal white matter tracts, fronto-limbic pathways, the internal capsule, and the uncinate fasciculus (Figure 1).
Figure 1a:
Neuroimaging Findings in TBI-related PTSD.
Figure 1b.Replicated Neuroimaging Findings in TBI-related PTSD in the Right Uncinate Fasciculus.
Conclusions
Additional inquiry with attention to specified imaging timing post-injury, consistent TBI definitions, clinician-diagnosed TBI and PTSD, and control groups is crucial to extrapolating discrepancies between primary and TBI-related PTSD. Prospective studies could further differentiate predisposing factors from sequelae of TBI-related
PTSD.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:48:30Z |
| format | Article |
| id | doaj.art-ae45ec03bf314ba3ba796fca99a04065 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:48:30Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-ae45ec03bf314ba3ba796fca99a040652023-11-17T05:07:08ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S471S47210.1192/j.eurpsy.2022.1198Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the LiteratureA. Esagoff0D. Stevens1M. Bray2B. Bryant3N. Daneshvari4D. Jung5C. Rodriguez6L. Richey7L. Luna8H. Sair9M. Peters10Johns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of AmericaJohns Hopkins University School of Medicine, Department Of Psychiatry And Behavioral Sciences, Baltimore, United States of America Introduction Neuroimaging has been a highly utilized technique for studying traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) independently of one another, however, neuroimaging has increasingly been identified as a useful tool in better understanding TBI-related psychiatric conditions, such as PTSD. Objectives To complete a systematic review of the literature examining neuroimaging findings in TBI-related PTSD and to highlight the current literature’s limitations in order to strengthen future research. Methods A PRISMA compliant literature search was conducted in PubMed (MEDLINE), PsychINFO, EMBASE, and Scopus databases prior to May of 2019. The initial database query yielded 4388 unique articles, which were narrowed down based on specified inclusion criteria (e.g., clear TBI definition, clinician-diagnosed PTSD, statistically analyzed relationship between neuroimaging and PTSD, quantified time interval between TBI and neuroimaging). Results A final cohort of 10 articles met inclusion criteria, comprising the findings of 482 participants with TBI. Key neuroanatomical findings among the included articles suggest that PTSD is associated with significant changes in whole-brain networks of resting state connectivity and disruptions in bilateral frontal and temporal white matter tracts, fronto-limbic pathways, the internal capsule, and the uncinate fasciculus (Figure 1). Figure 1a: Neuroimaging Findings in TBI-related PTSD. Figure 1b.Replicated Neuroimaging Findings in TBI-related PTSD in the Right Uncinate Fasciculus. Conclusions Additional inquiry with attention to specified imaging timing post-injury, consistent TBI definitions, clinician-diagnosed TBI and PTSD, and control groups is crucial to extrapolating discrepancies between primary and TBI-related PTSD. Prospective studies could further differentiate predisposing factors from sequelae of TBI-related PTSD. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822011981/type/journal_articleNeuroimagingPost-traumatic stress disordertraumatic brain injury |
| spellingShingle | A. Esagoff D. Stevens M. Bray B. Bryant N. Daneshvari D. Jung C. Rodriguez L. Richey L. Luna H. Sair M. Peters Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature European Psychiatry Neuroimaging Post-traumatic stress disorder traumatic brain injury |
| title | Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature |
| title_full | Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature |
| title_fullStr | Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature |
| title_full_unstemmed | Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature |
| title_short | Neuroimaging Correlates of Post-Traumatic Stress Disorder in Traumatic Brain Injury: A Systematic Review of the Literature |
| title_sort | neuroimaging correlates of post traumatic stress disorder in traumatic brain injury a systematic review of the literature |
| topic | Neuroimaging Post-traumatic stress disorder traumatic brain injury |
| url | https://www.cambridge.org/core/product/identifier/S0924933822011981/type/journal_article |
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