The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis
Background: Chronic spontaneous urticaria (CSU) is a disease with wheals and/or angioedema. Some drugs, especially antibiotics for <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication and the sulfone antibiotic dapsone, may be candidates for treating CSU. The present stu...
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| Format: | Article |
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MDPI AG
2021-02-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/2/156 |
| _version_ | 1797415419499249664 |
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| author | Jun Watanabe Junya Shimamoto Kazuhiko Kotani |
| author_facet | Jun Watanabe Junya Shimamoto Kazuhiko Kotani |
| author_sort | Jun Watanabe |
| collection | DOAJ |
| description | Background: Chronic spontaneous urticaria (CSU) is a disease with wheals and/or angioedema. Some drugs, especially antibiotics for <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication and the sulfone antibiotic dapsone, may be candidates for treating CSU. The present study assessed the efficacy of these antibiotic therapies for CSU. Methods: Databases (MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the World Health Organization International Clinical Trials Platform Search Portal and ClinicalTrials.gov) were searched until October 2020. Study selection, data abstraction and quality assessments were independently performed using the Grading of Recommendations Assessment, Development and Evaluation approach. The outcomes were the remission of CSU-related symptoms, activities and adverse events due to antibiotics for <i>H. pylori</i> eradication or dapsone. Results: Nine randomized controlled trials (RCTs; 361 patients) were included. The antibiotics for <i>H. pylori</i> eradication increased the remission rate (risk ratio (RR) = 3.99, 95% confidence interval (CI) = 1.31 to 12.14; I<sup>2</sup> = 0%), but dapsone did not (RR = 1.15, 95% CI = 0.74 to 1.78). Antibiotics for <i>H. pylori</i> eradication (standard mean difference (SMD) = 1.49, 95% CI = 0.80 to 2.18; I<sup>2</sup> = 69%) and dapsone (SMD = 7.00, 95% CI = 6.92 to 7.08; I<sup>2</sup> = 0%) improved symptoms. The evidence of certainty was moderate. Dapsone was associated with mild adverse events, whereas <i>H. pylori</i> eradication was not. Conclusion: Antibiotics, especially those for <i>H. pylori</i> eradication, improved the remission rate and symptoms of CSU with few adverse events. Further studies are needed. |
| first_indexed | 2024-03-09T05:48:23Z |
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| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T05:48:23Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-ae47aa02cf474112952fd5e1a866c28e2023-12-03T12:19:47ZengMDPI AGAntibiotics2079-63822021-02-0110215610.3390/antibiotics10020156The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-AnalysisJun Watanabe0Junya Shimamoto1Kazuhiko Kotani2Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, JapanDivision of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, JapanDivision of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, JapanBackground: Chronic spontaneous urticaria (CSU) is a disease with wheals and/or angioedema. Some drugs, especially antibiotics for <i>Helicobacter pylori</i> (<i>H. pylori</i>) eradication and the sulfone antibiotic dapsone, may be candidates for treating CSU. The present study assessed the efficacy of these antibiotic therapies for CSU. Methods: Databases (MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE, the World Health Organization International Clinical Trials Platform Search Portal and ClinicalTrials.gov) were searched until October 2020. Study selection, data abstraction and quality assessments were independently performed using the Grading of Recommendations Assessment, Development and Evaluation approach. The outcomes were the remission of CSU-related symptoms, activities and adverse events due to antibiotics for <i>H. pylori</i> eradication or dapsone. Results: Nine randomized controlled trials (RCTs; 361 patients) were included. The antibiotics for <i>H. pylori</i> eradication increased the remission rate (risk ratio (RR) = 3.99, 95% confidence interval (CI) = 1.31 to 12.14; I<sup>2</sup> = 0%), but dapsone did not (RR = 1.15, 95% CI = 0.74 to 1.78). Antibiotics for <i>H. pylori</i> eradication (standard mean difference (SMD) = 1.49, 95% CI = 0.80 to 2.18; I<sup>2</sup> = 69%) and dapsone (SMD = 7.00, 95% CI = 6.92 to 7.08; I<sup>2</sup> = 0%) improved symptoms. The evidence of certainty was moderate. Dapsone was associated with mild adverse events, whereas <i>H. pylori</i> eradication was not. Conclusion: Antibiotics, especially those for <i>H. pylori</i> eradication, improved the remission rate and symptoms of CSU with few adverse events. Further studies are needed.https://www.mdpi.com/2079-6382/10/2/156antibioticschronic urticariadapsone<i>Helicobacter pylori</i>systematic review |
| spellingShingle | Jun Watanabe Junya Shimamoto Kazuhiko Kotani The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis Antibiotics antibiotics chronic urticaria dapsone <i>Helicobacter pylori</i> systematic review |
| title | The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis |
| title_full | The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis |
| title_fullStr | The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis |
| title_short | The Effects of Antibiotics for <i>Helicobacter pylori</i> Eradication or Dapsone on Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis |
| title_sort | effects of antibiotics for i helicobacter pylori i eradication or dapsone on chronic spontaneous urticaria a systematic review and meta analysis |
| topic | antibiotics chronic urticaria dapsone <i>Helicobacter pylori</i> systematic review |
| url | https://www.mdpi.com/2079-6382/10/2/156 |
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