Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study
Background: Proteolytic enzymes and specific cytokines have been associated with the underlying mechanism of preterm premature rupture of membranes (PPROM), contributing to weakened amniotic membranes. This study aims to elucidate the predictive role of neutrophil-to-lymphocyte ratio (NLR) and plate...
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| Format: | Article |
| Language: | English |
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IMR Press
2024-01-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102028 |
| _version_ | 1797290983215333376 |
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| author | Pınar Tuğçe Özer Mehmet Özer Süleyman Cemil Oğlak Adnan Budak Abdurrahman Hamdi İnan Gökhan Tosun Emrah Töz Emine Zeynep Yılmaz Varol Gülseren Gökhan Bolluk Mehmet Özeren |
| author_facet | Pınar Tuğçe Özer Mehmet Özer Süleyman Cemil Oğlak Adnan Budak Abdurrahman Hamdi İnan Gökhan Tosun Emrah Töz Emine Zeynep Yılmaz Varol Gülseren Gökhan Bolluk Mehmet Özeren |
| author_sort | Pınar Tuğçe Özer |
| collection | DOAJ |
| description | Background: Proteolytic enzymes and specific cytokines have been associated with the underlying mechanism of preterm premature rupture of membranes (PPROM), contributing to weakened amniotic membranes. This study aims to elucidate the predictive role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) during the early stages of PPROM, given the limited existing literature exploring this relationship in second-trimester cases. Methods: This retrospective case-control study was performed from June 2018 to June 2023. We included 159 pregnant women diagnosed with mid-trimester PPROM and 573 pregnant women who gave birth at term. We obtained complete blood cell counts in all patients. We used a receiver operating characteristic (ROC) curve to evaluate the cut-off, sensitivity, and specificity values. Results: Complete blood count evaluations revealed that in the mid-trimester PPROM group, neutrophil count, leukocyte count, hemoglobin (Hb) levels, NLR, and PLR were notably higher than those delivering after the 37th gestational week. These observations were identified not only in the first-trimester but also within 24 hours after membrane rupture. Contrary to prior research and to conventional patterns, our study identified a diminished mid-trimester NLR in cases of PPROM compared to the control group. Conclusions: In our study, we identified significant differences in lymphocyte counts, platelet levels, NLR, and PLR values between the PPROM group and the control group. Our study suggests that the NLR and PLR values from the first-trimester might be powerful indicators of PPROM risk. |
| first_indexed | 2024-03-07T19:29:13Z |
| format | Article |
| id | doaj.art-ae480a511d0749c6a7fe85ebcbcca3ab |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-03-07T19:29:13Z |
| publishDate | 2024-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-ae480a511d0749c6a7fe85ebcbcca3ab2024-02-29T08:28:10ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632024-01-015122810.31083/j.ceog5102028S0390-6663(23)02284-4Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control StudyPınar Tuğçe Özer0Mehmet Özer1Süleyman Cemil Oğlak2Adnan Budak3Abdurrahman Hamdi İnan4Gökhan Tosun5Emrah Töz6Emine Zeynep Yılmaz7Varol Gülseren8Gökhan Bolluk9Mehmet Özeren10Department of Obstetrics and Gynecology, Ministry of Health Kemalpaşa State Hospital, 35170 Izmir, TurkeyDepartment of Perinatology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyDepartment of Obstetrics and Gynecology, Health Sciences University, Gazi Yaşargil Research and Training Hospital, 21070 Diyarbakır, TurkeyDepartment of Obstetrics and Gynecology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyDepartment of Obstetrics and Gynecology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyDepartment of Obstetrics and Gynecology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyDepartment of Obstetrics and Gynecology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyDepartment of Obstetrics and Gynecology, Bahçelievler Memorial Hospital, 34180 Istanbul, TurkeyDepartment of Gynecologic Oncology, Erciyes University Faculty of Medicine, 38039 Kayseri, TurkeyDepartment of Perinatology, Health Sciences University, Başakşehir Çam and Sakura City Hospital, 34480 Istanbul, TurkeyDepartment of Perinatology, Health Sciences University, Tepecik Training and Research Hospital, 35020 Izmir, TurkeyBackground: Proteolytic enzymes and specific cytokines have been associated with the underlying mechanism of preterm premature rupture of membranes (PPROM), contributing to weakened amniotic membranes. This study aims to elucidate the predictive role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) during the early stages of PPROM, given the limited existing literature exploring this relationship in second-trimester cases. Methods: This retrospective case-control study was performed from June 2018 to June 2023. We included 159 pregnant women diagnosed with mid-trimester PPROM and 573 pregnant women who gave birth at term. We obtained complete blood cell counts in all patients. We used a receiver operating characteristic (ROC) curve to evaluate the cut-off, sensitivity, and specificity values. Results: Complete blood count evaluations revealed that in the mid-trimester PPROM group, neutrophil count, leukocyte count, hemoglobin (Hb) levels, NLR, and PLR were notably higher than those delivering after the 37th gestational week. These observations were identified not only in the first-trimester but also within 24 hours after membrane rupture. Contrary to prior research and to conventional patterns, our study identified a diminished mid-trimester NLR in cases of PPROM compared to the control group. Conclusions: In our study, we identified significant differences in lymphocyte counts, platelet levels, NLR, and PLR values between the PPROM group and the control group. Our study suggests that the NLR and PLR values from the first-trimester might be powerful indicators of PPROM risk.https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102028neutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratiomid-trimester preterm premature rupture of membranes |
| spellingShingle | Pınar Tuğçe Özer Mehmet Özer Süleyman Cemil Oğlak Adnan Budak Abdurrahman Hamdi İnan Gökhan Tosun Emrah Töz Emine Zeynep Yılmaz Varol Gülseren Gökhan Bolluk Mehmet Özeren Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study Clinical and Experimental Obstetrics & Gynecology neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio mid-trimester preterm premature rupture of membranes |
| title | Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study |
| title_full | Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study |
| title_fullStr | Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study |
| title_full_unstemmed | Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study |
| title_short | Evaluating the Predictive Potential of Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in the Second-Trimester Preterm Premature Rupture of Membranes (PPROM): A Retrospective Case-Control Study |
| title_sort | evaluating the predictive potential of neutrophil to lymphocyte and platelet to lymphocyte ratios in the second trimester preterm premature rupture of membranes pprom a retrospective case control study |
| topic | neutrophil-to-lymphocyte ratio platelet-to-lymphocyte ratio mid-trimester preterm premature rupture of membranes |
| url | https://www.imrpress.com/journal/CEOG/51/2/10.31083/j.ceog5102028 |
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