Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study
Background: Asthma is a heterogeneous disease presenting with various phenotypes usually characterized by chronic airway inflammation. Aims and Objectives: The aim of the study was to identify epidemiology of bronchial asthma phenotypes in patients attending to tertiary care center. Materials...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2022-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://nepjol.info/index.php/AJMS/article/view/43900 |
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| author | Satish Babu Mededi Jereen Varghese Ragulan Rajalingam Viswambhar V Nithin Thomas |
| author_facet | Satish Babu Mededi Jereen Varghese Ragulan Rajalingam Viswambhar V Nithin Thomas |
| author_sort | Satish Babu Mededi |
| collection | DOAJ |
| description | Background: Asthma is a heterogeneous disease presenting with various phenotypes usually characterized by chronic airway inflammation.
Aims and Objectives: The aim of the study was to identify epidemiology of bronchial asthma phenotypes in patients attending to
tertiary care center.
Materials and Methods: This was a descriptive cross-sectional study involving 69 patients who are suspected to have asthma according to the Global Initiative for Asthma guidelines. The data of each patient were collected on a proforma specially designed for this study on demographic data, socioeconomic status, body mass index, exposure to environmental factors, and other history-related questions. Sputum cytology and absolute eosinophil count were also examined using coGuide and P<0.05 was considered significant. Asthma phenotypes were the primary outcome and association of environmental factors with asthma phenotypes was the secondary outcome.
Results: Out of 69, majority 26 (37.7%) were aged 31–40 years; 35 (50.7%) males and 34 (49.3%) were females. Fifty-eight (84.1%) were illiterate and 46 (66.7%) belonged to low class. Sputum cytology report showed that majority of them, 66.7%, had eosinophilia. The majority, 48 (69.6%), of the participants were triggered by weather and 55.1% had a history of respiratory tract infections. Thirty-three (47.83%) participants had obesity associate asthma, 34 (49.28%) had allergic asthma, and 20 (28.99%) had smoking-related asthma phenotypes. The difference in the proportion of few environment factor was significant for allergic and smoking-related asthma (P>0.005).
Conclusion: The factors associated with the asthma phenotypes will help us further in anticipating the clinical course and better management of the specific phenotypes. |
| first_indexed | 2024-04-14T06:00:09Z |
| format | Article |
| id | doaj.art-ae493b91fe0347e5b64925cf70ab90cc |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-14T06:00:09Z |
| publishDate | 2022-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-ae493b91fe0347e5b64925cf70ab90cc2022-12-22T02:08:48ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-08-01138110115https://doi.org/10.3126/ajms.v13i8.43900Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional studySatish Babu Mededi 0https://orcid.org/0000-0002-0010-3144Jereen Varghese 1https://orcid.org/0000-0003-1151-9492Ragulan Rajalingam 2https://orcid.org/0000-0003-2926-6673Viswambhar V 3https://orcid.org/0000-0001-8764-8720Nithin Thomas 4https://orcid.org/0000-0002-8347-9509Professor, Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India Assistant Professor, Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India Associate Professor, Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India Professor and Head, Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India Professor, Department of Respiratory Medicine, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India Background: Asthma is a heterogeneous disease presenting with various phenotypes usually characterized by chronic airway inflammation. Aims and Objectives: The aim of the study was to identify epidemiology of bronchial asthma phenotypes in patients attending to tertiary care center. Materials and Methods: This was a descriptive cross-sectional study involving 69 patients who are suspected to have asthma according to the Global Initiative for Asthma guidelines. The data of each patient were collected on a proforma specially designed for this study on demographic data, socioeconomic status, body mass index, exposure to environmental factors, and other history-related questions. Sputum cytology and absolute eosinophil count were also examined using coGuide and P<0.05 was considered significant. Asthma phenotypes were the primary outcome and association of environmental factors with asthma phenotypes was the secondary outcome. Results: Out of 69, majority 26 (37.7%) were aged 31–40 years; 35 (50.7%) males and 34 (49.3%) were females. Fifty-eight (84.1%) were illiterate and 46 (66.7%) belonged to low class. Sputum cytology report showed that majority of them, 66.7%, had eosinophilia. The majority, 48 (69.6%), of the participants were triggered by weather and 55.1% had a history of respiratory tract infections. Thirty-three (47.83%) participants had obesity associate asthma, 34 (49.28%) had allergic asthma, and 20 (28.99%) had smoking-related asthma phenotypes. The difference in the proportion of few environment factor was significant for allergic and smoking-related asthma (P>0.005). Conclusion: The factors associated with the asthma phenotypes will help us further in anticipating the clinical course and better management of the specific phenotypes.https://nepjol.info/index.php/AJMS/article/view/43900asthma; biomarkers; phenotypes; respiratory tract infections; tobacco smoking |
| spellingShingle | Satish Babu Mededi Jereen Varghese Ragulan Rajalingam Viswambhar V Nithin Thomas Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study Asian Journal of Medical Sciences asthma; biomarkers; phenotypes; respiratory tract infections; tobacco smoking |
| title | Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study |
| title_full | Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study |
| title_fullStr | Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study |
| title_full_unstemmed | Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study |
| title_short | Influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center – A cross-sectional study |
| title_sort | influence of epidemiological factors on asthma phenotypes among asthma patients attending a tertiary care center a cross sectional study |
| topic | asthma; biomarkers; phenotypes; respiratory tract infections; tobacco smoking |
| url | https://nepjol.info/index.php/AJMS/article/view/43900 |
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