Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions
Intrauterine adhesions (IUAs) are important causes of female infertility, mainly but not always caused by iatrogenic endometrial injury. The microbiome of the female reproductive tract, including the vagina and uterine cavity, plays an important role in health and disease. Immune regulation imbalanc...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-03-01
|
| Series: | Medicine in Microecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097821000185 |
| _version_ | 1818329763522019328 |
|---|---|
| author | Xiaoqing Li Fang Xu Xiaoli Sha Xianyan Chen Qiong hui Pan Xuefen He Hongping Zhang Yuanyuan Zheng |
| author_facet | Xiaoqing Li Fang Xu Xiaoli Sha Xianyan Chen Qiong hui Pan Xuefen He Hongping Zhang Yuanyuan Zheng |
| author_sort | Xiaoqing Li |
| collection | DOAJ |
| description | Intrauterine adhesions (IUAs) are important causes of female infertility, mainly but not always caused by iatrogenic endometrial injury. The microbiome of the female reproductive tract, including the vagina and uterine cavity, plays an important role in health and disease. Immune regulation imbalance caused by reproductive tract microecological disorders can act in the formation mechanism of IUAs. Here we collected clinical laboratory indicators, the vaginal secretions and uterine secretions of 6 women with and 8 women without IUAs, with a history of curettage. Vaginal and uterine cavity microbes were detected by high-throughput sequencing technology. Compared with the women without IUAs, the proportion of Lactobacillus in vaginal microbes was decreased and the proportion of Bacteroides was increased in the IUAs. The α-diversity index in the vaginal microbiome was significantly positively correlated with the hematocrit and erythrocyte count (P ＜0.05). These clinical and microbiological indicators could be used to indicate the occurrence of IUAs, so this study has clinical guiding significance for detecting and preventing them. |
| first_indexed | 2024-12-13T12:53:14Z |
| format | Article |
| id | doaj.art-ae4a2c3103314016bdbd61fc92efd8dc |
| institution | Directory Open Access Journal |
| issn | 2590-0978 |
| language | English |
| last_indexed | 2024-12-13T12:53:14Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj.art-ae4a2c3103314016bdbd61fc92efd8dc2022-12-21T23:45:16ZengElsevierMedicine in Microecology2590-09782022-03-0111100050Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesionsXiaoqing Li0Fang Xu1Xiaoli Sha2Xianyan Chen3Qiong hui Pan4Xuefen He5Hongping Zhang6Yuanyuan Zheng7Wenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaWenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaWenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaWenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaWenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaWenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaCorresponding author.; Wenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaCorresponding author.; Wenzhou People's Hospital/ Wenzhou Maternal and Child Health Care Hospital/ the Third Clinical Institute Affiliated to Wenzhou Medical University/ the Third Affiliated Hospital of Shanghai University, No. 57 Canghou Street, Lucheng District, Wenzhou, Zhejiang, 325000, ChinaIntrauterine adhesions (IUAs) are important causes of female infertility, mainly but not always caused by iatrogenic endometrial injury. The microbiome of the female reproductive tract, including the vagina and uterine cavity, plays an important role in health and disease. Immune regulation imbalance caused by reproductive tract microecological disorders can act in the formation mechanism of IUAs. Here we collected clinical laboratory indicators, the vaginal secretions and uterine secretions of 6 women with and 8 women without IUAs, with a history of curettage. Vaginal and uterine cavity microbes were detected by high-throughput sequencing technology. Compared with the women without IUAs, the proportion of Lactobacillus in vaginal microbes was decreased and the proportion of Bacteroides was increased in the IUAs. The α-diversity index in the vaginal microbiome was significantly positively correlated with the hematocrit and erythrocyte count (P ＜0.05). These clinical and microbiological indicators could be used to indicate the occurrence of IUAs, so this study has clinical guiding significance for detecting and preventing them.http://www.sciencedirect.com/science/article/pii/S2590097821000185Intrauterine adhesionsBiochemical indicatorsVaginal microbiomeUterine cavity microbiome |
| spellingShingle | Xiaoqing Li Fang Xu Xiaoli Sha Xianyan Chen Qiong hui Pan Xuefen He Hongping Zhang Yuanyuan Zheng Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions Medicine in Microecology Intrauterine adhesions Biochemical indicators Vaginal microbiome Uterine cavity microbiome |
| title | Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| title_full | Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| title_fullStr | Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| title_full_unstemmed | Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| title_short | Biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| title_sort | biochemical indicators and vaginal microecological abnormalities indicate the occurrence of intrauterine adhesions |
| topic | Intrauterine adhesions Biochemical indicators Vaginal microbiome Uterine cavity microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2590097821000185 |
| work_keys_str_mv | AT xiaoqingli biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT fangxu biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT xiaolisha biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT xianyanchen biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT qionghuipan biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT xuefenhe biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT hongpingzhang biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions AT yuanyuanzheng biochemicalindicatorsandvaginalmicroecologicalabnormalitiesindicatetheoccurrenceofintrauterineadhesions |