Reactive Glia Inflammatory Signaling Pathways and Epilepsy
Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function is a common factor that predisposes or contributes to the generation of seizures. At the same time, acute seizures upreg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/11/4096 |
| _version_ | 1797565802264657920 |
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| author | Pascual Sanz Maria Adelaida Garcia-Gimeno |
| author_facet | Pascual Sanz Maria Adelaida Garcia-Gimeno |
| author_sort | Pascual Sanz |
| collection | DOAJ |
| description | Neuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function is a common factor that predisposes or contributes to the generation of seizures. At the same time, acute seizures upregulate the production of pro-inflammatory cytokines in microglia and astrocytes, triggering a downstream cascade of inflammatory mediators. Therefore, epileptic seizures and inflammatory mediators form a vicious positive feedback loop, reinforcing each other. In this work, we have reviewed the main glial signaling pathways involved in neuroinflammation, how they are affected in epileptic conditions, and the therapeutic opportunities they offer to prevent these disorders. |
| first_indexed | 2024-03-10T19:18:10Z |
| format | Article |
| id | doaj.art-ae4aa2b2b2aa4730884091a58c1d11d2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:18:10Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ae4aa2b2b2aa4730884091a58c1d11d22023-11-20T03:13:50ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012111409610.3390/ijms21114096Reactive Glia Inflammatory Signaling Pathways and EpilepsyPascual Sanz0Maria Adelaida Garcia-Gimeno1Instituto de Biomedicina de Valencia (CSIC) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Jaime Roig 11, 46010 Valencia, SpainDepartment of Biotechnology, Escuela Técnica Superior de Ingeniería Agronómica y del Medio Natural (ETSIAMN), Universitat Politècnica de València, 46022 Valencia, SpainNeuroinflammation and epilepsy are interconnected. Brain inflammation promotes neuronal hyper-excitability and seizures, and dysregulation in the glia immune-inflammatory function is a common factor that predisposes or contributes to the generation of seizures. At the same time, acute seizures upregulate the production of pro-inflammatory cytokines in microglia and astrocytes, triggering a downstream cascade of inflammatory mediators. Therefore, epileptic seizures and inflammatory mediators form a vicious positive feedback loop, reinforcing each other. In this work, we have reviewed the main glial signaling pathways involved in neuroinflammation, how they are affected in epileptic conditions, and the therapeutic opportunities they offer to prevent these disorders.https://www.mdpi.com/1422-0067/21/11/4096inflammationsignaling pathwaysepilepsyreactive astrocytesmicroglia |
| spellingShingle | Pascual Sanz Maria Adelaida Garcia-Gimeno Reactive Glia Inflammatory Signaling Pathways and Epilepsy International Journal of Molecular Sciences inflammation signaling pathways epilepsy reactive astrocytes microglia |
| title | Reactive Glia Inflammatory Signaling Pathways and Epilepsy |
| title_full | Reactive Glia Inflammatory Signaling Pathways and Epilepsy |
| title_fullStr | Reactive Glia Inflammatory Signaling Pathways and Epilepsy |
| title_full_unstemmed | Reactive Glia Inflammatory Signaling Pathways and Epilepsy |
| title_short | Reactive Glia Inflammatory Signaling Pathways and Epilepsy |
| title_sort | reactive glia inflammatory signaling pathways and epilepsy |
| topic | inflammation signaling pathways epilepsy reactive astrocytes microglia |
| url | https://www.mdpi.com/1422-0067/21/11/4096 |
| work_keys_str_mv | AT pascualsanz reactivegliainflammatorysignalingpathwaysandepilepsy AT mariaadelaidagarciagimeno reactivegliainflammatorysignalingpathwaysandepilepsy |