BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD
Nowadays, definitive treatment for the end-stage organ failure is transplantation. Tissue engineering is an up to date solution to create the effective substitute of the defective organ. It involves the reconstitution of viable tissue with the use of autologous cells grown on connective tissue matri...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2015-02-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/storage/no1_2015/popandopulo_1_2015_.pdf |
| _version_ | 1827888214712516608 |
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| author | A. G. Popandopulo M. V. Savchuk D. L. Yudickiy |
| author_facet | A. G. Popandopulo M. V. Savchuk D. L. Yudickiy |
| author_sort | A. G. Popandopulo |
| collection | DOAJ |
| description | Nowadays, definitive treatment for the end-stage organ failure is transplantation. Tissue engineering is an up to date solution to create the effective substitute of the defective organ. It involves the reconstitution of viable tissue with the use of autologous cells grown on connective tissue matrix, which has been acellularized before. Basis for the prothesis should be morphologically and physically nonmodified, so in case of making vessel-valvular biological prosthesises the decellularized extracellular matrix is the best variant. The xenogeneic extracellular matrix is economically and ethically more useful. The possibility of preservation of the morphological and chemical properties of matrix structure initiates the process of programmed cell death. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis doesn’t cause the tissue damages. One of the ways of realizing the apoptosis is the usage of EDTA — chelate, which binds the Ca2+ ions. |
| first_indexed | 2024-03-12T20:30:32Z |
| format | Article |
| id | doaj.art-ae4ae23166014491b71ef52a1b3a2ae0 |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T20:30:32Z |
| publishDate | 2015-02-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-ae4ae23166014491b71ef52a1b3a2ae02023-08-02T00:04:33ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2015-02-0181828710.15407/biotech8.01.082BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHODA. G. Popandopulo0 M. V. Savchuk1D. L. Yudickiy2SI « Husak Institute of Urgent and Recovery Surgery», Donetsk, UkraineSI « Husak Institute of Urgent and Recovery Surgery», Donetsk, UkraineGorky Donetsk National Medical University, Donetsk, UkraineNowadays, definitive treatment for the end-stage organ failure is transplantation. Tissue engineering is an up to date solution to create the effective substitute of the defective organ. It involves the reconstitution of viable tissue with the use of autologous cells grown on connective tissue matrix, which has been acellularized before. Basis for the prothesis should be morphologically and physically nonmodified, so in case of making vessel-valvular biological prosthesises the decellularized extracellular matrix is the best variant. The xenogeneic extracellular matrix is economically and ethically more useful. The possibility of preservation of the morphological and chemical properties of matrix structure initiates the process of programmed cell death. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis doesn’t cause the tissue damages. One of the ways of realizing the apoptosis is the usage of EDTA — chelate, which binds the Ca2+ ions.http://biotechnology.kiev.ua/images/storage/no1_2015/popandopulo_1_2015_.pdftissue engineeringextracellular matrixdecellularizationapoptosischelate |
| spellingShingle | A. G. Popandopulo M. V. Savchuk D. L. Yudickiy BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD Biotechnologia Acta tissue engineering extracellular matrix decellularization apoptosis chelate |
| title | BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD |
| title_full | BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD |
| title_fullStr | BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD |
| title_full_unstemmed | BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD |
| title_short | BIOTECHNOLOGICAL CONDITIONS OF VALVE PROSTHESES CREATING BY TISSUE ENGINEERING METHOD |
| title_sort | biotechnological conditions of valve prostheses creating by tissue engineering method |
| topic | tissue engineering extracellular matrix decellularization apoptosis chelate |
| url | http://biotechnology.kiev.ua/images/storage/no1_2015/popandopulo_1_2015_.pdf |
| work_keys_str_mv | AT agpopandopulo biotechnologicalconditionsofvalveprosthesescreatingbytissueengineeringmethod AT mvsavchuk biotechnologicalconditionsofvalveprosthesescreatingbytissueengineeringmethod AT dlyudickiy biotechnologicalconditionsofvalveprosthesescreatingbytissueengineeringmethod |