Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination
Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formati...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/8/1883 |
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| author | Martin Pisárčik Miloš Lukáč Josef Jampílek František Bilka Andrea Bilková Ľudmila Pašková Ferdinand Devínsky Renáta Horáková Matěj Březina Tomáš Opravil |
| author_facet | Martin Pisárčik Miloš Lukáč Josef Jampílek František Bilka Andrea Bilková Ľudmila Pašková Ferdinand Devínsky Renáta Horáková Matěj Březina Tomáš Opravil |
| author_sort | Martin Pisárčik |
| collection | DOAJ |
| description | Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50–60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants. |
| first_indexed | 2024-03-10T08:32:30Z |
| format | Article |
| id | doaj.art-ae4c0338b0fe41f09111189e512ab10c |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T08:32:30Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ae4c0338b0fe41f09111189e512ab10c2023-11-22T08:57:11ZengMDPI AGNanomaterials2079-49912021-07-01118188310.3390/nano11081883Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity DeterminationMartin Pisárčik0Miloš Lukáč1Josef Jampílek2František Bilka3Andrea Bilková4Ľudmila Pašková5Ferdinand Devínsky6Renáta Horáková7Matěj Březina8Tomáš Opravil9Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaDepartment of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaDepartment of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, SK-84215 Bratislava, SlovakiaDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaFaculty of Pharmacy, Comenius University, SK-83232 Bratislava, SlovakiaComenius University, SK-81499 Bratislava, SlovakiaMaterials Research Centre, Faculty of Chemistry, University of Technology, CZ-61200 Brno, Czech RepublicMaterials Research Centre, Faculty of Chemistry, University of Technology, CZ-61200 Brno, Czech RepublicPhosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50–60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants.https://www.mdpi.com/2079-4991/11/8/1883phosphoniumsilver nanoparticlesdynamic light scatteringzeta potentialHep G2 cellscytotoxicity |
| spellingShingle | Martin Pisárčik Miloš Lukáč Josef Jampílek František Bilka Andrea Bilková Ľudmila Pašková Ferdinand Devínsky Renáta Horáková Matěj Březina Tomáš Opravil Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination Nanomaterials phosphonium silver nanoparticles dynamic light scattering zeta potential Hep G2 cells cytotoxicity |
| title | Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination |
| title_full | Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination |
| title_fullStr | Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination |
| title_full_unstemmed | Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination |
| title_short | Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination |
| title_sort | silver nanoparticles stabilized with phosphorus containing heterocyclic surfactants synthesis physico chemical properties and biological activity determination |
| topic | phosphonium silver nanoparticles dynamic light scattering zeta potential Hep G2 cells cytotoxicity |
| url | https://www.mdpi.com/2079-4991/11/8/1883 |
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