Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis
<p>Abstract</p> <p>Background</p> <p>The U.S. FDA/CDC Vaccine Adverse Event Reporting System (VAERS) provides a valuable data source for post-vaccination adverse event analyses. The structured data in the system has been widely used, but the information in the write-up...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-12-01
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| Series: | Journal of Biomedical Semantics |
| Online Access: | http://www.jbiomedsem.com/content/3/1/13 |
| _version_ | 1818059460101275648 |
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| author | Tao Cui He Yongqun Yang Hannah Poland Gregory A Chute Christopher G |
| author_facet | Tao Cui He Yongqun Yang Hannah Poland Gregory A Chute Christopher G |
| author_sort | Tao Cui |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The U.S. FDA/CDC Vaccine Adverse Event Reporting System (VAERS) provides a valuable data source for post-vaccination adverse event analyses. The structured data in the system has been widely used, but the information in the write-up narratives is rarely included in these kinds of analyses. In fact, the unstructured nature of the narratives makes the data embedded in them difficult to be used for any further studies.</p> <p>Results</p> <p>We developed an ontology-based approach to represent the data in the narratives in a “machine-understandable” way, so that it can be easily queried and further analyzed. Our focus is the time aspect in the data for time trending analysis. The Time Event Ontology (TEO), Ontology of Adverse Events (OAE), and Vaccine Ontology (VO) are leveraged for the semantic representation of this purpose. A VAERS case report is presented as a use case for the ontological representations. The advantages of using our ontology-based Semantic web representation and data analysis are emphasized.</p> <p>Conclusions</p> <p>We believe that representing both the structured data and the data from write-up narratives in an integrated, unified, and “machine-understandable” way can improve research for vaccine safety analyses, causality assessments, and retrospective studies.</p> |
| first_indexed | 2024-12-10T13:16:52Z |
| format | Article |
| id | doaj.art-ae4de82ca50145bb9ec42524121a07f7 |
| institution | Directory Open Access Journal |
| issn | 2041-1480 |
| language | English |
| last_indexed | 2024-12-10T13:16:52Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Semantics |
| spelling | doaj.art-ae4de82ca50145bb9ec42524121a07f72022-12-22T01:47:31ZengBMCJournal of Biomedical Semantics2041-14802012-12-01311310.1186/2041-1480-3-13Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysisTao CuiHe YongqunYang HannahPoland Gregory AChute Christopher G<p>Abstract</p> <p>Background</p> <p>The U.S. FDA/CDC Vaccine Adverse Event Reporting System (VAERS) provides a valuable data source for post-vaccination adverse event analyses. The structured data in the system has been widely used, but the information in the write-up narratives is rarely included in these kinds of analyses. In fact, the unstructured nature of the narratives makes the data embedded in them difficult to be used for any further studies.</p> <p>Results</p> <p>We developed an ontology-based approach to represent the data in the narratives in a “machine-understandable” way, so that it can be easily queried and further analyzed. Our focus is the time aspect in the data for time trending analysis. The Time Event Ontology (TEO), Ontology of Adverse Events (OAE), and Vaccine Ontology (VO) are leveraged for the semantic representation of this purpose. A VAERS case report is presented as a use case for the ontological representations. The advantages of using our ontology-based Semantic web representation and data analysis are emphasized.</p> <p>Conclusions</p> <p>We believe that representing both the structured data and the data from write-up narratives in an integrated, unified, and “machine-understandable” way can improve research for vaccine safety analyses, causality assessments, and retrospective studies.</p>http://www.jbiomedsem.com/content/3/1/13 |
| spellingShingle | Tao Cui He Yongqun Yang Hannah Poland Gregory A Chute Christopher G Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis Journal of Biomedical Semantics |
| title | Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis |
| title_full | Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis |
| title_fullStr | Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis |
| title_full_unstemmed | Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis |
| title_short | Ontology-based time information representation of vaccine adverse events in VAERS for temporal analysis |
| title_sort | ontology based time information representation of vaccine adverse events in vaers for temporal analysis |
| url | http://www.jbiomedsem.com/content/3/1/13 |
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