MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-05-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/27/5/10.31083/j.fbl2705167 |
| _version_ | 1828363780935909376 |
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| author | Khoa Nguyen Minh N. Tran Andrew Rivera Thomas Cheng Gabrielle O. Windsor Abraham B. Chabot Jane E. Cavanaugh Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Patrick T. Flaherty Matthew E. Burow |
| author_facet | Khoa Nguyen Minh N. Tran Andrew Rivera Thomas Cheng Gabrielle O. Windsor Abraham B. Chabot Jane E. Cavanaugh Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Patrick T. Flaherty Matthew E. Burow |
| author_sort | Khoa Nguyen |
| collection | DOAJ |
| description | The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases. |
| first_indexed | 2024-04-14T05:06:50Z |
| format | Article |
| id | doaj.art-ae4f71ffb677486896b12ea1d2ecc0c0 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-04-14T05:06:50Z |
| publishDate | 2022-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-ae4f71ffb677486896b12ea1d2ecc0c02022-12-22T02:10:41ZengIMR PressFrontiers in Bioscience-Landmark2768-67012022-05-0127516710.31083/j.fbl2705167S2768-6701(22)00518-4MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer TypesKhoa Nguyen0Minh N. Tran1Andrew Rivera2Thomas Cheng3Gabrielle O. Windsor4Abraham B. Chabot5Jane E. Cavanaugh6Bridgette M. Collins-Burow7Sean B. Lee8David H. Drewry9Patrick T. Flaherty10Matthew E. Burow11Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USADepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USAUNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chemical Biology and Medicinal Chemistry Division, SGC-UNC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USADepartment of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USADepartment of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USAThe mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.https://www.imrpress.com/journal/FBL/27/5/10.31083/j.fbl2705167map kinasesmapkmap3kunderstudied kinasedark kinomeilluminating the druggable genomecancer |
| spellingShingle | Khoa Nguyen Minh N. Tran Andrew Rivera Thomas Cheng Gabrielle O. Windsor Abraham B. Chabot Jane E. Cavanaugh Bridgette M. Collins-Burow Sean B. Lee David H. Drewry Patrick T. Flaherty Matthew E. Burow MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types Frontiers in Bioscience-Landmark map kinases mapk map3k understudied kinase dark kinome illuminating the druggable genome cancer |
| title | MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_full | MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_fullStr | MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_full_unstemmed | MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_short | MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types |
| title_sort | map3k family review and correlations with patient survival outcomes in various cancer types |
| topic | map kinases mapk map3k understudied kinase dark kinome illuminating the druggable genome cancer |
| url | https://www.imrpress.com/journal/FBL/27/5/10.31083/j.fbl2705167 |
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