PRC1 sustains the integrity of neural fate in the absence of PRC2 function

PRC1 sustains the integrity of neural fate in the absence of PRC2 function

Polycomb repressive complexes (PRCs) 1 and 2 maintain stable cellular memories of early fate decisions by establishing heritable patterns of gene repression. PRCs repress transcription through histone modifications and chromatin compaction, but their roles in neuronal subtype diversification are poo...

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Bibliographic Details
Main Authors: Ayana Sawai, Sarah Pfennig, Milica Bulajić, Alexander Miller, Alireza Khodadadi-Jamayran, Esteban O Mazzoni, Jeremy S Dasen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
neural development
motor neuron
hox gene
polycomb protein
Online Access:https://elifesciences.org/articles/72769

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