Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1
Pancreatic cancer (PaC) is a highly aggressive disease, with poor response to current treatments and 5-year survival rates of 10–15%. PaC progression is facilitated by its interaction with the complex and multifaceted tumor microenvironment (TME). In the TME, cancer cells and surrounding stromal cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/10/2779 |
| _version_ | 1797600727999184896 |
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| author | Jiawei Chang Zoe H. Y. Lo Shafi Alenizi Zaklina Kovacevic |
| author_facet | Jiawei Chang Zoe H. Y. Lo Shafi Alenizi Zaklina Kovacevic |
| author_sort | Jiawei Chang |
| collection | DOAJ |
| description | Pancreatic cancer (PaC) is a highly aggressive disease, with poor response to current treatments and 5-year survival rates of 10–15%. PaC progression is facilitated by its interaction with the complex and multifaceted tumor microenvironment (TME). In the TME, cancer cells and surrounding stromal cells constantly communicate with each other via the secretion and uptake of factors including cytokines, chemokines, growth factors, metabolites, and extracellular vesicles (EVs), reshaping the landscape of PaC. Recent studies demonstrated that the metastasis suppressor N-myc downstream regulated 1 (NDRG1) not only inhibits oncogenic signaling pathways in PaC cells but also alters the communication between PaC cells and the surrounding stroma. In fact, NDRG1 was found to influence the secretome of PaC cells, alter cancer cell metabolism, and interfere with intracellular trafficking and intercellular communication between PaC cells and surrounding fibroblasts. This review will present recent advancements in understanding the role of NDRG1 in PaC progression, with a focus on how this molecule influences PaC-stroma communication and its potential for re-shaping the PaC TME. |
| first_indexed | 2024-03-11T03:51:58Z |
| format | Article |
| id | doaj.art-ae511a34451f4386aafb900bc4b63d4b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:51:58Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ae511a34451f4386aafb900bc4b63d4b2023-11-18T00:48:50ZengMDPI AGCancers2072-66942023-05-011510277910.3390/cancers15102779Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1Jiawei Chang0Zoe H. Y. Lo1Shafi Alenizi2Zaklina Kovacevic3School of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Sydney 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Sydney 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Sydney 2006, AustraliaSchool of Medical Sciences, Faculty of Medicine & Health, University of Sydney, Sydney 2006, AustraliaPancreatic cancer (PaC) is a highly aggressive disease, with poor response to current treatments and 5-year survival rates of 10–15%. PaC progression is facilitated by its interaction with the complex and multifaceted tumor microenvironment (TME). In the TME, cancer cells and surrounding stromal cells constantly communicate with each other via the secretion and uptake of factors including cytokines, chemokines, growth factors, metabolites, and extracellular vesicles (EVs), reshaping the landscape of PaC. Recent studies demonstrated that the metastasis suppressor N-myc downstream regulated 1 (NDRG1) not only inhibits oncogenic signaling pathways in PaC cells but also alters the communication between PaC cells and the surrounding stroma. In fact, NDRG1 was found to influence the secretome of PaC cells, alter cancer cell metabolism, and interfere with intracellular trafficking and intercellular communication between PaC cells and surrounding fibroblasts. This review will present recent advancements in understanding the role of NDRG1 in PaC progression, with a focus on how this molecule influences PaC-stroma communication and its potential for re-shaping the PaC TME.https://www.mdpi.com/2072-6694/15/10/2779cancerpancreatic cancerpancreatic ductal adenocarcinomapancreatic cancer tumor microenvironmentNDRG1extracellular vesicles |
| spellingShingle | Jiawei Chang Zoe H. Y. Lo Shafi Alenizi Zaklina Kovacevic Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 Cancers cancer pancreatic cancer pancreatic ductal adenocarcinoma pancreatic cancer tumor microenvironment NDRG1 extracellular vesicles |
| title | Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 |
| title_full | Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 |
| title_fullStr | Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 |
| title_full_unstemmed | Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 |
| title_short | Re-Shaping the Pancreatic Cancer Tumor Microenvironment: A New Role for the Metastasis Suppressor NDRG1 |
| title_sort | re shaping the pancreatic cancer tumor microenvironment a new role for the metastasis suppressor ndrg1 |
| topic | cancer pancreatic cancer pancreatic ductal adenocarcinoma pancreatic cancer tumor microenvironment NDRG1 extracellular vesicles |
| url | https://www.mdpi.com/2072-6694/15/10/2779 |
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