The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris
The importance of acetylcholine (ACh) in keratinocyte adhesion and acantholysis has been investigated over the last three decades, particularly in the pathophysiology of autoimmune blistering dermatoses. Pemphigus vulgaris (PV) is an autoimmune blistering skin disease where autoantibody-mediated sup...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/3/354 |
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| author | Delila Pouldar Foulad Nicola Cirillo Sergei A. Grando |
| author_facet | Delila Pouldar Foulad Nicola Cirillo Sergei A. Grando |
| author_sort | Delila Pouldar Foulad |
| collection | DOAJ |
| description | The importance of acetylcholine (ACh) in keratinocyte adhesion and acantholysis has been investigated over the last three decades, particularly in the pathophysiology of autoimmune blistering dermatoses. Pemphigus vulgaris (PV) is an autoimmune blistering skin disease where autoantibody-mediated suprabasilar intraepidermal splitting causes flaccid blisters and non-healing erosions of the oral mucosa and sometimes also of the skin. Historically, acantholysis in PV was thought to be driven by anti-desmoglein (Dsg) antibodies. Herein, we describe the role of autoantibodies against keratinocyte muscarinic and nicotinic acetylcholine receptors, as well as the annexin-like molecule pemphaxin that also binds ACh, in the immunopathogenesis of PV. The identification of targets in this disease is important, as they may lead to novel diagnostic and therapeutic options in the future for this potentially deadly disease. |
| first_indexed | 2024-03-11T06:54:47Z |
| format | Article |
| id | doaj.art-ae51eb35ed864b60a92cf389c762a772 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T06:54:47Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-ae51eb35ed864b60a92cf389c762a7722023-11-17T09:40:58ZengMDPI AGBiology2079-77372023-02-0112335410.3390/biology12030354The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus VulgarisDelila Pouldar Foulad0Nicola Cirillo1Sergei A. Grando2Division of Dermatology, University of California, Los Angeles, CA 90095, USAMelbourne Dental School, University of Melbourne, Carlton, VI 3053, AustraliaDepartment of Dermatology, University of California, Irvine, CA 92697, USAThe importance of acetylcholine (ACh) in keratinocyte adhesion and acantholysis has been investigated over the last three decades, particularly in the pathophysiology of autoimmune blistering dermatoses. Pemphigus vulgaris (PV) is an autoimmune blistering skin disease where autoantibody-mediated suprabasilar intraepidermal splitting causes flaccid blisters and non-healing erosions of the oral mucosa and sometimes also of the skin. Historically, acantholysis in PV was thought to be driven by anti-desmoglein (Dsg) antibodies. Herein, we describe the role of autoantibodies against keratinocyte muscarinic and nicotinic acetylcholine receptors, as well as the annexin-like molecule pemphaxin that also binds ACh, in the immunopathogenesis of PV. The identification of targets in this disease is important, as they may lead to novel diagnostic and therapeutic options in the future for this potentially deadly disease.https://www.mdpi.com/2079-7737/12/3/354pemphigusacetylcholinekeratinocyte adhesionacantholysisnicotinic receptormuscarinic receptor |
| spellingShingle | Delila Pouldar Foulad Nicola Cirillo Sergei A. Grando The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris Biology pemphigus acetylcholine keratinocyte adhesion acantholysis nicotinic receptor muscarinic receptor |
| title | The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris |
| title_full | The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris |
| title_fullStr | The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris |
| title_full_unstemmed | The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris |
| title_short | The Role of Non-Neuronal Acetylcholine in the Autoimmune Blistering Disease Pemphigus Vulgaris |
| title_sort | role of non neuronal acetylcholine in the autoimmune blistering disease pemphigus vulgaris |
| topic | pemphigus acetylcholine keratinocyte adhesion acantholysis nicotinic receptor muscarinic receptor |
| url | https://www.mdpi.com/2079-7737/12/3/354 |
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