Global Transcriptome Analyses of Cellular and Viral mRNAs during HAdV-C5 Infection Highlight New Aspects of Viral mRNA Biogenesis and Cytoplasmic Viral mRNA Accumulations

Global Transcriptome Analyses of Cellular and Viral mRNAs during HAdV-C5 Infection Highlight New Aspects of Viral mRNA Biogenesis and Cytoplasmic Viral mRNA Accumulations

It is well established that human adenoviruses such as species C, types 2 and 5 (HAdV-C2 and HAdV-C5), induce a nearly complete shutoff of host-cell protein synthesis in the infected cell, simultaneously directing very efficient production of viral proteins. Such preferential expression of viral ove...

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Bibliographic Details
Main Authors: Margarita Valdés Alemán, Luca D. Bertzbach, Thomas Speiseder, Wing Hang Ip, Ramón A. González, Thomas Dobner
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Viruses
Subjects:
human adenovirus
mRNA biogenesis
mRNA export
next-generation sequencing (NGS)
nucleocytoplasmic RNA transport
temporal expression
Online Access:https://www.mdpi.com/1999-4915/14/11/2428

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