Anterograde and Retrograde Propagation of Inoculated Human Tau Fibrils and Tau Oligomers in a Non-Transgenic Rat Tauopathy Model

Anterograde and Retrograde Propagation of Inoculated Human Tau Fibrils and Tau Oligomers in a Non-Transgenic Rat Tauopathy Model

The tauopathy of Alzheimer’s disease (AD) is first observed in the brainstem and entorhinal cortex, spreading trans-synaptically along specific pathways to other brain regions with recognizable patterns. Tau propagation occurs retrogradely and anterogradely (trans-synaptically) along a given pathway...

Full description

Bibliographic Details
Main Authors:	Lea Langer Horvat, Ena Španić Popovački, Mirjana Babić Leko, Klara Zubčić, Luka Horvat, Maja Mustapić, Patrick R. Hof, Goran Šimić
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	Biomedicines
Subjects:	Alzheimer’s disease cognition neurofibrillary degeneration spatial working memory tau fibrils tau oligomers
Online Access:	https://www.mdpi.com/2227-9059/11/4/1004

Similar Items

Are tau aggregates toxic or protective in tauopathies?
by: Catherine M Cowan, et al.
Published: (2013-08-01)

Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
by: Shweta Kishor Sonawane, et al.
Published: (2021-02-01)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease.
by: Paola eFlores-Rodríguez, et al.
Published: (2015-02-01)

Characteristics of tau oligomers
by: Yan eRen, et al.
Published: (2013-07-01)

Tau Oligomers Neurotoxicity
by: Grazyna Niewiadomska, et al.
Published: (2021-01-01)

Prefibrillar Tau oligomers alter the nucleic acid protective function of Tau in hippocampal neurons in vivo
by: Marie Violet, et al.
Published: (2015-10-01)

Tau Oligomers and Fibrils Exhibit Differential Patterns of Seeding and Association With RNA Binding Proteins
by: Lulu Jiang, et al.
Published: (2020-09-01)

Tau oligomers: the toxic player at synapses in Alzheimer’s disease
by: Marcos Jair Guerrero-Munoz, et al.
Published: (2015-12-01)

Toxic tau: structural origins of tau aggregation in Alzheimer's disease
by: Abdullah Al Mamun, et al.
Published: (2020-01-01)

Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model
by: YoungDoo Kim, et al.
Published: (2016-03-01)

The Significance of Tau Aggregates in the Human Brain
by: Rudy J. Castellani
Published: (2020-12-01)

Understanding the Pathophysiological Actions of Tau Oligomers: A Critical Review of Current Electrophysiological Approaches
by: Emily Hill, et al.
Published: (2020-08-01)

Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction
by: Giacomo Siano, et al.
Published: (2021-09-01)

The prion-like transmission of tau oligomers via exosomes
by: Noel A. Jackson, et al.
Published: (2022-08-01)

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies
by: Yuxing Xia, et al.
Published: (2020-06-01)

Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
by: Ena Španić, et al.
Published: (2019-10-01)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
by: Goran Šimić, et al.
Published: (2016-01-01)

Heterogeneous Tau Oligomers as Molecular Targets for Alzheimer’s Disease and Related Tauopathies
by: Chih Hung Lo
Published: (2022-11-01)

Tau oligomers
by: Naruhiko eSahara, et al.
Published: (2014-01-01)

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia
by: Rashmi Das, et al.
Published: (2020-01-01)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
by: Julia E. Gerson, et al.
Published: (2018-03-01)

Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
by: Woo Shik Shin, et al.
Published: (2019-10-01)

de novo MAPT mutation G335A causes severe brain atrophy, 3R and 4R PHF-tau pathology and early onset frontotemporal dementia
by: Kunie Ando, et al.
Published: (2020-06-01)

Nasal Rifampicin Halts the Progression of Tauopathy by Inhibiting Tau Oligomer Propagation in Alzheimer Brain Extract-Injected Mice
by: Tomohiro Umeda, et al.
Published: (2022-01-01)

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils
by: Yann Fichou, et al.
Published: (2019-12-01)

Formation and propagation of tau oligomeric seeds
by: Julia E. Gerson, et al.
Published: (2013-07-01)

TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
by: Mauro Montalbano, et al.
Published: (2020-12-01)

TAU OLIGOMERS AS DIRECT TARGETS FOR ALZHEIMER´S DIAGNOSIS AND NOVEL DRUGS
by: Leonardo eGuzman-Martinez, et al.
Published: (2013-10-01)

Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer’s disease model
by: Fernando Goñi, et al.
Published: (2018-01-01)

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice
by: Céline Héraud, et al.
Published: (2014-02-01)

Tau-mediated synaptic damage in Alzheimer’s disease
by: Jadhav Santosh, et al.
Published: (2015-01-01)

Neurofibrillary tau depositions emerge with subthreshold cerebral beta-amyloidosis in down syndrome
by: Matthew D. Zammit, et al.
Published: (2021-01-01)

Alzheimer’s Disease and Tau Self-Assembly: In the Search of the Missing Link
by: Andrea González, et al.
Published: (2022-04-01)

Oligomeric tau-targeted immunotherapy in Tg4510 mice
by: Sulana Schroeder, et al.
Published: (2017-06-01)

Tau Biomarkers in Dementia: Positron Emission Tomography Radiopharmaceuticals in Tauopathy Assessment and Future Perspective
by: Maria Ricci, et al.
Published: (2021-11-01)

Tau: The Center of a Signaling Nexus in Alzheimer’s Disease
by: Shahzad eKhan, et al.
Published: (2016-02-01)

Hyperphosphorylation-induced tau oligomers
by: Khalid eIqbal, et al.
Published: (2013-08-01)

Pathology of different tau protein species in neurodegenerative diseases: Alzheimer’s disease, corticobasal degeneration, and progressive supranuclear palsy
by: Mohammad Majidi, et al.
Published: (2021-07-01)

Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds
by: Marta Perez-Rando, et al.
Published: (2020-10-01)

Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein
by: Gaoping Lin, et al.
Published: (2021-11-01)