Prediabetes: challenges and opportunities
In the world, the number of patients with carbohydrate metabolism disorders is steadily growing. Over the past 10 years, the number of patients with diabetes mellitus in the world has more than doubled. Moreover, there is not only an increase in the number of patients with diabetes mellitus, predomi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2021-09-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6352 |
| _version_ | 1797841305722683392 |
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| author | T. B. Morgunova I. V. Glinkina V. V. Fadeev |
| author_facet | T. B. Morgunova I. V. Glinkina V. V. Fadeev |
| author_sort | T. B. Morgunova |
| collection | DOAJ |
| description | In the world, the number of patients with carbohydrate metabolism disorders is steadily growing. Over the past 10 years, the number of patients with diabetes mellitus in the world has more than doubled. Moreover, there is not only an increase in the number of patients with diabetes mellitus, predominantly type 2 diabetes, but also with prediabetes. The term «prediabetes» means impaired glucose tolerance and impaired fasting glycemia. To date, it is obvious that the development of prediabetes lead not only to the higher risk of diabetes mellitus in the future, but also of cardiovascular diseases. Factors that increase the risk of cardiovascular events in patients with prediabetes includeare the following: insulin resistance, accompanied by arterial hypertension and dyslipidemia, and postprandial hyperglycemia. Therefore, it is very important to timely identify patients from the risk group, diagnose and treat carbohydrate metabolism disorders already at the stage of prediabetes. Also it is very important to identify the patients from the risk group, diagnose and treat carbohydrate metabolism disorders at the stage of prediabetes. Treatment of patients with prediabetes implies, first of all, lifestyle modification (moderate hypocaloric nutrition with predominant restriction of fats and simple carbohydrates and regular physical activity of moderate intensity) in order to reduce weight. If lifestyle changes are ineffective, drug therapy may be prescribed. The article discusses the studies conducted to assess the effectiveness of lifestyle modification, as well as various options for antihyperglycemic therapy (metformin, glucagon-like peptide receptor agonists, alpha-glucosidase inhibitors, orlistat) for the treatment of patients with prediabetes. It also provides data on long-term follow-up of patients with prediabetes who received different treatment options. |
| first_indexed | 2024-04-09T16:28:54Z |
| format | Article |
| id | doaj.art-ae54258652524d2bb362ca0df5a529de |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:28:54Z |
| publishDate | 2021-09-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-ae54258652524d2bb362ca0df5a529de2023-04-23T06:57:12ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-09-0101222022710.21518/2079-701X-2021-12-220-2275730Prediabetes: challenges and opportunitiesT. B. Morgunova0I. V. Glinkina1V. V. Fadeev2Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)In the world, the number of patients with carbohydrate metabolism disorders is steadily growing. Over the past 10 years, the number of patients with diabetes mellitus in the world has more than doubled. Moreover, there is not only an increase in the number of patients with diabetes mellitus, predominantly type 2 diabetes, but also with prediabetes. The term «prediabetes» means impaired glucose tolerance and impaired fasting glycemia. To date, it is obvious that the development of prediabetes lead not only to the higher risk of diabetes mellitus in the future, but also of cardiovascular diseases. Factors that increase the risk of cardiovascular events in patients with prediabetes includeare the following: insulin resistance, accompanied by arterial hypertension and dyslipidemia, and postprandial hyperglycemia. Therefore, it is very important to timely identify patients from the risk group, diagnose and treat carbohydrate metabolism disorders already at the stage of prediabetes. Also it is very important to identify the patients from the risk group, diagnose and treat carbohydrate metabolism disorders at the stage of prediabetes. Treatment of patients with prediabetes implies, first of all, lifestyle modification (moderate hypocaloric nutrition with predominant restriction of fats and simple carbohydrates and regular physical activity of moderate intensity) in order to reduce weight. If lifestyle changes are ineffective, drug therapy may be prescribed. The article discusses the studies conducted to assess the effectiveness of lifestyle modification, as well as various options for antihyperglycemic therapy (metformin, glucagon-like peptide receptor agonists, alpha-glucosidase inhibitors, orlistat) for the treatment of patients with prediabetes. It also provides data on long-term follow-up of patients with prediabetes who received different treatment options.https://www.med-sovet.pro/jour/article/view/6352diabetes mellitustreatmentmetforminimpaired glucose toleranceimpaired fasting glycemia |
| spellingShingle | T. B. Morgunova I. V. Glinkina V. V. Fadeev Prediabetes: challenges and opportunities Медицинский совет diabetes mellitus treatment metformin impaired glucose tolerance impaired fasting glycemia |
| title | Prediabetes: challenges and opportunities |
| title_full | Prediabetes: challenges and opportunities |
| title_fullStr | Prediabetes: challenges and opportunities |
| title_full_unstemmed | Prediabetes: challenges and opportunities |
| title_short | Prediabetes: challenges and opportunities |
| title_sort | prediabetes challenges and opportunities |
| topic | diabetes mellitus treatment metformin impaired glucose tolerance impaired fasting glycemia |
| url | https://www.med-sovet.pro/jour/article/view/6352 |
| work_keys_str_mv | AT tbmorgunova prediabeteschallengesandopportunities AT ivglinkina prediabeteschallengesandopportunities AT vvfadeev prediabeteschallengesandopportunities |