Ginsenosides in Panax genus and their biosynthesis
Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, stems, leaves, and flowers. The content and composi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383520308510 |
| _version_ | 1829134863104475136 |
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| author | Maoqi Hou Rufeng Wang Shujuan Zhao Zhengtao Wang |
| author_facet | Maoqi Hou Rufeng Wang Shujuan Zhao Zhengtao Wang |
| author_sort | Maoqi Hou |
| collection | DOAJ |
| description | Ginsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, stems, leaves, and flowers. The content and composition of ginsenosides are varied in different ginseng species, and in different parts of a certain plant. In this review, we summarized the representative saponins structures, their distributions and the contents in nearly 20 Panax species, and updated the biosynthetic pathways of ginsenosides focusing on enzymes responsible for structural diversified ginsenoside biosynthesis. We also emphasized the transcription factors in ginsenoside biosynthesis and non-coding RNAs in the growth of Panax genus plants, and highlighted the current three major biotechnological applications for ginsenosides production. This review covered advances in the past four decades, providing more clues for chemical discrimination and assessment on certain ginseng plants, new perspectives for rational evaluation and utilization of ginseng resource, and potential strategies for production of specific ginsenosides. |
| first_indexed | 2024-12-14T18:13:37Z |
| format | Article |
| id | doaj.art-ae552e1a921244c98fa40fd822003d7f |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-12-14T18:13:37Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-ae552e1a921244c98fa40fd822003d7f2022-12-21T22:52:14ZengElsevierActa Pharmaceutica Sinica B2211-38352021-07-0111718131834Ginsenosides in Panax genus and their biosynthesisMaoqi Hou0Rufeng Wang1Shujuan Zhao2Zhengtao Wang3The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaThe SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCorresponding author. Tel: 86 21 51322576, fax: +86 21 51322495 (Shujuan Zhao); Tel.: +86 21 51322507, fax: +86 21 51322505 (Zhengtao Wang).; The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCorresponding author. Tel: 86 21 51322576, fax: +86 21 51322495 (Shujuan Zhao); Tel.: +86 21 51322507, fax: +86 21 51322505 (Zhengtao Wang).; The SATCM Key Laboratory for New Resources & Quality Evaluation of Chinese Medicine, The MOE Key Laboratory for Standardization of Chinese Medicines and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaGinsenosides are a series of glycosylated triterpenoids which belong to protopanaxadiol (PPD)-, protopanaxatriol (PPT)-, ocotillol (OCT)- and oleanane (OA)-type saponins known as active compounds of Panax genus. They are accumulated in plant roots, stems, leaves, and flowers. The content and composition of ginsenosides are varied in different ginseng species, and in different parts of a certain plant. In this review, we summarized the representative saponins structures, their distributions and the contents in nearly 20 Panax species, and updated the biosynthetic pathways of ginsenosides focusing on enzymes responsible for structural diversified ginsenoside biosynthesis. We also emphasized the transcription factors in ginsenoside biosynthesis and non-coding RNAs in the growth of Panax genus plants, and highlighted the current three major biotechnological applications for ginsenosides production. This review covered advances in the past four decades, providing more clues for chemical discrimination and assessment on certain ginseng plants, new perspectives for rational evaluation and utilization of ginseng resource, and potential strategies for production of specific ginsenosides.http://www.sciencedirect.com/science/article/pii/S2211383520308510GinsenosidePanax speciesBiosynthetic pathwayTranscription factorsNon-coding RNAsBiotechnological approach |
| spellingShingle | Maoqi Hou Rufeng Wang Shujuan Zhao Zhengtao Wang Ginsenosides in Panax genus and their biosynthesis Acta Pharmaceutica Sinica B Ginsenoside Panax species Biosynthetic pathway Transcription factors Non-coding RNAs Biotechnological approach |
| title | Ginsenosides in Panax genus and their biosynthesis |
| title_full | Ginsenosides in Panax genus and their biosynthesis |
| title_fullStr | Ginsenosides in Panax genus and their biosynthesis |
| title_full_unstemmed | Ginsenosides in Panax genus and their biosynthesis |
| title_short | Ginsenosides in Panax genus and their biosynthesis |
| title_sort | ginsenosides in panax genus and their biosynthesis |
| topic | Ginsenoside Panax species Biosynthetic pathway Transcription factors Non-coding RNAs Biotechnological approach |
| url | http://www.sciencedirect.com/science/article/pii/S2211383520308510 |
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