Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases
The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca<sup>2+</sup>, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the Ca...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/19/3075 |
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| author | Hezhen Chu Zhenqian Qin Jun Ma Yimin Xie Haifeng Shi Jie Gu Baiqiang Shi |
| author_facet | Hezhen Chu Zhenqian Qin Jun Ma Yimin Xie Haifeng Shi Jie Gu Baiqiang Shi |
| author_sort | Hezhen Chu |
| collection | DOAJ |
| description | The calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca<sup>2+</sup>, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy–lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart–kidney interaction; the associated common causes are also discussed. |
| first_indexed | 2024-03-09T21:54:03Z |
| format | Article |
| id | doaj.art-ae5573691e6b48bf85ee76c7b199513e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:54:03Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ae5573691e6b48bf85ee76c7b199513e2023-11-23T20:02:18ZengMDPI AGCells2073-44092022-09-011119307510.3390/cells11193075Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular DiseasesHezhen Chu0Zhenqian Qin1Jun Ma2Yimin Xie3Haifeng Shi4Jie Gu5Baiqiang Shi6Department of Urology, Yixing Traditional Chinese Medicine Hospital, Yixing 214200, ChinaDepartment of Urology, Affiliated Hospital of Jiangsu University-Yixing Hospital, Yixing 214200, ChinaDepartment of Urology, Yixing Traditional Chinese Medicine Hospital, Yixing 214200, ChinaDepartment of Urology, Affiliated Hospital of Jiangsu University-Yixing Hospital, Yixing 214200, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, ChinaSchool of Life Sciences, Jiangsu University, Zhenjiang 212013, ChinaDepartment of Urology, Yixing Traditional Chinese Medicine Hospital, Yixing 214200, ChinaThe calcium-sensing receptor (CaSR), a G-protein-coupled receptor (GPCR), is a cell-surface-located receptor that can induce highly diffusible messengers (IP3, Ca<sup>2+</sup>, cAMP) in the cytoplasm to activate various cellular responses. Recently, it has also been suggested that the CaSR mediates the intracellular communications between the endoplasmic reticulum (ER), mitochondria, nucleus, protease/proteasome, and autophagy–lysosome, which are involved in related cardiovascular diseases. The complex intracellular signaling of this receptor challenges it as a valuable therapeutic target. It is, therefore, necessary to understand the mechanisms behind the signaling characteristics of this receptor in intracellular communication. This review provides an overview of the recent research progress on the various regulatory mechanisms of the CaSR in related cardiovascular diseases and the heart–kidney interaction; the associated common causes are also discussed.https://www.mdpi.com/2073-4409/11/19/3075calcium-sensing receptorcardiovascular diseasesnucleusmitochondriaproteasomelysosome |
| spellingShingle | Hezhen Chu Zhenqian Qin Jun Ma Yimin Xie Haifeng Shi Jie Gu Baiqiang Shi Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases Cells calcium-sensing receptor cardiovascular diseases nucleus mitochondria proteasome lysosome |
| title | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
| title_full | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
| title_fullStr | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
| title_full_unstemmed | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
| title_short | Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases |
| title_sort | calcium sensing receptor casr mediated intracellular communication in cardiovascular diseases |
| topic | calcium-sensing receptor cardiovascular diseases nucleus mitochondria proteasome lysosome |
| url | https://www.mdpi.com/2073-4409/11/19/3075 |
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