Decoding the glycoproteome: a new frontier for biomarker discovery in cancer
Abstract Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating tumor cells (CTCs) and DNA (ctDNA) have shown enormous potential due to their non-invasive nature and the implications in precision canc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13045-024-01532-x |
| _version_ | 1827310023409139712 |
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| author | Kai He Maryam Baniasad Hyunwoo Kwon Tomislav Caval Gege Xu Carlito Lebrilla Daniel W. Hommes Carolyn Bertozzi |
| author_facet | Kai He Maryam Baniasad Hyunwoo Kwon Tomislav Caval Gege Xu Carlito Lebrilla Daniel W. Hommes Carolyn Bertozzi |
| author_sort | Kai He |
| collection | DOAJ |
| description | Abstract Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating tumor cells (CTCs) and DNA (ctDNA) have shown enormous potential due to their non-invasive nature and the implications in precision cancer management. Recently, liquid biopsy has been further expanded to profile glycoproteins, which are the products of post-translational modifications of proteins and play key roles in both normal and pathological processes, including cancers. The advancements in chemical and mass spectrometry-based technologies and artificial intelligence-based platforms have enabled extensive studies of cancer and organ-specific changes in glycans and glycoproteins through glycomics and glycoproteomics. Glycoproteomic analysis has emerged as a promising tool for biomarker discovery and development in early detection of cancers and prediction of treatment efficacy including response to immunotherapies. These biomarkers could play a crucial role in aiding in early intervention and personalized therapy decisions. In this review, we summarize the significant advance in cancer glycoproteomic biomarker studies and the promise and challenges in integration into clinical practice to improve cancer patient care. |
| first_indexed | 2024-04-24T19:53:05Z |
| format | Article |
| id | doaj.art-ae573905f74943fb97daba19a8d6c98f |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-04-24T19:53:05Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-ae573905f74943fb97daba19a8d6c98f2024-03-24T12:29:53ZengBMCJournal of Hematology & Oncology1756-87222024-03-0117112110.1186/s13045-024-01532-xDecoding the glycoproteome: a new frontier for biomarker discovery in cancerKai He0Maryam Baniasad1Hyunwoo Kwon2Tomislav Caval3Gege Xu4Carlito Lebrilla5Daniel W. Hommes6Carolyn Bertozzi7James Comprehensive Cancer Center, The Ohio State UniversityInterVenn BiosciencesJames Comprehensive Cancer Center, The Ohio State UniversityInterVenn BiosciencesInterVenn BiosciencesDepartment of Biochemistry and Molecular Medicine, UC Davis HealthInterVenn BiosciencesDepartment of Chemistry, Stanford UniversityAbstract Cancer early detection and treatment response prediction continue to pose significant challenges. Cancer liquid biopsies focusing on detecting circulating tumor cells (CTCs) and DNA (ctDNA) have shown enormous potential due to their non-invasive nature and the implications in precision cancer management. Recently, liquid biopsy has been further expanded to profile glycoproteins, which are the products of post-translational modifications of proteins and play key roles in both normal and pathological processes, including cancers. The advancements in chemical and mass spectrometry-based technologies and artificial intelligence-based platforms have enabled extensive studies of cancer and organ-specific changes in glycans and glycoproteins through glycomics and glycoproteomics. Glycoproteomic analysis has emerged as a promising tool for biomarker discovery and development in early detection of cancers and prediction of treatment efficacy including response to immunotherapies. These biomarkers could play a crucial role in aiding in early intervention and personalized therapy decisions. In this review, we summarize the significant advance in cancer glycoproteomic biomarker studies and the promise and challenges in integration into clinical practice to improve cancer patient care.https://doi.org/10.1186/s13045-024-01532-xGlycoproteomicsBiomarkerCancerScreening |
| spellingShingle | Kai He Maryam Baniasad Hyunwoo Kwon Tomislav Caval Gege Xu Carlito Lebrilla Daniel W. Hommes Carolyn Bertozzi Decoding the glycoproteome: a new frontier for biomarker discovery in cancer Journal of Hematology & Oncology Glycoproteomics Biomarker Cancer Screening |
| title | Decoding the glycoproteome: a new frontier for biomarker discovery in cancer |
| title_full | Decoding the glycoproteome: a new frontier for biomarker discovery in cancer |
| title_fullStr | Decoding the glycoproteome: a new frontier for biomarker discovery in cancer |
| title_full_unstemmed | Decoding the glycoproteome: a new frontier for biomarker discovery in cancer |
| title_short | Decoding the glycoproteome: a new frontier for biomarker discovery in cancer |
| title_sort | decoding the glycoproteome a new frontier for biomarker discovery in cancer |
| topic | Glycoproteomics Biomarker Cancer Screening |
| url | https://doi.org/10.1186/s13045-024-01532-x |
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