The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized by high morbidity and mortality rates. Alpha-fetoprotein (AFP) is a glycoprotein synthesized by the liver and yolk sac during fetal development. However, the serum levels of AFP exhibit a significant correlation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1363695/full |
| _version_ | 1797215844317528064 |
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| author | Yan Lu Bo Lin Mengsen Li Mengsen Li Mengsen Li |
| author_facet | Yan Lu Bo Lin Mengsen Li Mengsen Li Mengsen Li |
| author_sort | Yan Lu |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized by high morbidity and mortality rates. Alpha-fetoprotein (AFP) is a glycoprotein synthesized by the liver and yolk sac during fetal development. However, the serum levels of AFP exhibit a significant correlation with the onset and progression of HCC in adults. Extensive research has demonstrated that the tumor microenvironment (TME) plays a crucial role in the malignant transformation of HCC, and AFP is a key factor in the TME, promoting HCC development. The objective of this review was to analyze the existing knowledge regarding the role of AFP in the TME. Specifically, this review focused on the effect of AFP on various cells in the TME, tumor immune evasion, and clinical application of AFP in the diagnosis and treatment of HCC. These findings offer valuable insights into the clinical treatment of HCC. |
| first_indexed | 2024-04-24T11:36:31Z |
| format | Article |
| id | doaj.art-ae57a4c01c004abf8b0942ca00c5ccef |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T11:36:31Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ae57a4c01c004abf8b0942ca00c5ccef2024-04-10T05:14:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.13636951363695The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinomaYan Lu0Bo Lin1Mengsen Li2Mengsen Li3Mengsen Li4Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, Hainan, ChinaHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, Hainan, ChinaHainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, Hainan, ChinaDepartment of Medical Oncology, Second Affiliated Hospital, Hainan Medical College, Haikou, Hainan, ChinaInstitution of Tumor, Hainan Medical College, Haikou, Hainan, ChinaHepatocellular carcinoma (HCC) is a prevalent malignant cancer worldwide, characterized by high morbidity and mortality rates. Alpha-fetoprotein (AFP) is a glycoprotein synthesized by the liver and yolk sac during fetal development. However, the serum levels of AFP exhibit a significant correlation with the onset and progression of HCC in adults. Extensive research has demonstrated that the tumor microenvironment (TME) plays a crucial role in the malignant transformation of HCC, and AFP is a key factor in the TME, promoting HCC development. The objective of this review was to analyze the existing knowledge regarding the role of AFP in the TME. Specifically, this review focused on the effect of AFP on various cells in the TME, tumor immune evasion, and clinical application of AFP in the diagnosis and treatment of HCC. These findings offer valuable insights into the clinical treatment of HCC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1363695/fullhepatocellular carcinomaAFPtumor microenvironmentimmune escapeliver cancer stem cellsimmunotherapy |
| spellingShingle | Yan Lu Bo Lin Mengsen Li Mengsen Li Mengsen Li The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma Frontiers in Oncology hepatocellular carcinoma AFP tumor microenvironment immune escape liver cancer stem cells immunotherapy |
| title | The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| title_full | The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| title_fullStr | The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| title_full_unstemmed | The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| title_short | The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| title_sort | role of alpha fetoprotein in the tumor microenvironment of hepatocellular carcinoma |
| topic | hepatocellular carcinoma AFP tumor microenvironment immune escape liver cancer stem cells immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1363695/full |
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