The protective role of conjunctival goblet cell mucin sialylation
Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-37101-y |
| _version_ | 1797864303223635968 |
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| author | Moe Matsuzawa Tomoaki Ando Saaya Fukase Meiko Kimura Yasuharu Kume Takuma Ide Kumi Izawa Ayako Kaitani Mutsuko Hara Eri Nakamura Anna Kamei Akira Matsuda Nobuhiro Nakano Keiko Maeda Norihiro Tada Hideoki Ogawa Ko Okumura Akira Murakami Nobuyuki Ebihara Jiro Kitaura |
| author_facet | Moe Matsuzawa Tomoaki Ando Saaya Fukase Meiko Kimura Yasuharu Kume Takuma Ide Kumi Izawa Ayako Kaitani Mutsuko Hara Eri Nakamura Anna Kamei Akira Matsuda Nobuhiro Nakano Keiko Maeda Norihiro Tada Hideoki Ogawa Ko Okumura Akira Murakami Nobuyuki Ebihara Jiro Kitaura |
| author_sort | Moe Matsuzawa |
| collection | DOAJ |
| description | Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis. |
| first_indexed | 2024-04-09T22:50:42Z |
| format | Article |
| id | doaj.art-ae591070ee1148c581bcc54f2ff35511 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:50:42Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ae591070ee1148c581bcc54f2ff355112023-03-22T11:40:16ZengNature PortfolioNature Communications2041-17232023-03-0114111510.1038/s41467-023-37101-yThe protective role of conjunctival goblet cell mucin sialylationMoe Matsuzawa0Tomoaki Ando1Saaya Fukase2Meiko Kimura3Yasuharu Kume4Takuma Ide5Kumi Izawa6Ayako Kaitani7Mutsuko Hara8Eri Nakamura9Anna Kamei10Akira Matsuda11Nobuhiro Nakano12Keiko Maeda13Norihiro Tada14Hideoki Ogawa15Ko Okumura16Akira Murakami17Nobuyuki Ebihara18Jiro Kitaura19Atopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineResearch Institute for Diseases of Old Age, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineDepartment of Ophthalmology, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineCenter for Biomedical Research Resources, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineDepartment of Ophthalmology, Juntendo University Graduate School of MedicineDepartment of Ophthalmology, Juntendo University Urayasu HospitalAtopy (Allergy) Research Center, Juntendo University Graduate School of MedicineConjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.https://doi.org/10.1038/s41467-023-37101-y |
| spellingShingle | Moe Matsuzawa Tomoaki Ando Saaya Fukase Meiko Kimura Yasuharu Kume Takuma Ide Kumi Izawa Ayako Kaitani Mutsuko Hara Eri Nakamura Anna Kamei Akira Matsuda Nobuhiro Nakano Keiko Maeda Norihiro Tada Hideoki Ogawa Ko Okumura Akira Murakami Nobuyuki Ebihara Jiro Kitaura The protective role of conjunctival goblet cell mucin sialylation Nature Communications |
| title | The protective role of conjunctival goblet cell mucin sialylation |
| title_full | The protective role of conjunctival goblet cell mucin sialylation |
| title_fullStr | The protective role of conjunctival goblet cell mucin sialylation |
| title_full_unstemmed | The protective role of conjunctival goblet cell mucin sialylation |
| title_short | The protective role of conjunctival goblet cell mucin sialylation |
| title_sort | protective role of conjunctival goblet cell mucin sialylation |
| url | https://doi.org/10.1038/s41467-023-37101-y |
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