The protective role of conjunctival goblet cell mucin sialylation

The protective role of conjunctival goblet cell mucin sialylation

Conjunctival goblet cells secrete mucins that are heavily glycosylated. Here, the authors show that sialylation of mucins is essential for capturing and encapsulates allergen particles and thus reduces the risk for developing allergic conjunctivitis.

Bibliographic Details
Main Authors: Moe Matsuzawa, Tomoaki Ando, Saaya Fukase, Meiko Kimura, Yasuharu Kume, Takuma Ide, Kumi Izawa, Ayako Kaitani, Mutsuko Hara, Eri Nakamura, Anna Kamei, Akira Matsuda, Nobuhiro Nakano, Keiko Maeda, Norihiro Tada, Hideoki Ogawa, Ko Okumura, Akira Murakami, Nobuyuki Ebihara, Jiro Kitaura
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37101-y

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