B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia
B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintain...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/11/1686 |
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| author | Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li |
| author_facet | Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li |
| author_sort | Ning Xia |
| collection | DOAJ |
| description | B lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintaining vascular homeostasis under physiological conditions. In young mice not exposed to any known risk factors, the lack of B cells led to massive endothelial dysfunction. The vascular dysfunction in B cell-deficient mice was associated with an increased number of neutrophils in the circulating blood. Neutrophil depletion in B cell-deficient mice resulted in the complete normalization of vascular function, indicating a causal role of neutrophilia. Moreover, vascular function in B cell-deficient mice could be restored by adoptive transfer of naive B-1 cells isolated from wild-type mice. Interestingly, B-1 cell transfer also reduced the number of neutrophils in the recipient mice, further supporting the involvement of neutrophils in the vascular pathology caused by B cell-deficiency. In conclusion, we report in the present study the hitherto undescribed role of B lymphocytes in regulating vascular function. B cell dysregulation may represent a crucial mechanism in vascular pathology. |
| first_indexed | 2024-03-10T05:41:31Z |
| format | Article |
| id | doaj.art-ae5f35f2a9c24aa0be52938250a875bd |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T05:41:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ae5f35f2a9c24aa0be52938250a875bd2023-11-22T22:31:56ZengMDPI AGBiomedicines2227-90592021-11-01911168610.3390/biomedicines9111686B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing NeutrophiliaNing Xia0Solveig Hasselwander1Gisela Reifenberg2Alice Habermeier3Ellen I. Closs4Maximilian Mimmler5Rebecca Jung6Susanne Karbach7Jérémy Lagrange8Philip Wenzel9Andreas Daiber10Thomas Münzel11Nadine Hövelmeyer12Ari Waisman13Huige Li14Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyInstitute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyCenter for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Cardiology, Cardiology 1, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyInstitute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyInstitute for Molecular Medicine, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyDepartment of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, GermanyB lymphocytes have been implicated in the development of insulin resistance, atherosclerosis and certain types of hypertension. In contrast to these studies, which were performed under pathological conditions, the present study provides evidence for the protective effect of B lymphocytes in maintaining vascular homeostasis under physiological conditions. In young mice not exposed to any known risk factors, the lack of B cells led to massive endothelial dysfunction. The vascular dysfunction in B cell-deficient mice was associated with an increased number of neutrophils in the circulating blood. Neutrophil depletion in B cell-deficient mice resulted in the complete normalization of vascular function, indicating a causal role of neutrophilia. Moreover, vascular function in B cell-deficient mice could be restored by adoptive transfer of naive B-1 cells isolated from wild-type mice. Interestingly, B-1 cell transfer also reduced the number of neutrophils in the recipient mice, further supporting the involvement of neutrophils in the vascular pathology caused by B cell-deficiency. In conclusion, we report in the present study the hitherto undescribed role of B lymphocytes in regulating vascular function. B cell dysregulation may represent a crucial mechanism in vascular pathology.https://www.mdpi.com/2227-9059/9/11/1686B lymphocytesvascular functionneutrophil granulocytesnitric oxide |
| spellingShingle | Ning Xia Solveig Hasselwander Gisela Reifenberg Alice Habermeier Ellen I. Closs Maximilian Mimmler Rebecca Jung Susanne Karbach Jérémy Lagrange Philip Wenzel Andreas Daiber Thomas Münzel Nadine Hövelmeyer Ari Waisman Huige Li B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia Biomedicines B lymphocytes vascular function neutrophil granulocytes nitric oxide |
| title | B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_full | B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_fullStr | B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_full_unstemmed | B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_short | B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia |
| title_sort | b lymphocyte deficiency in mice causes vascular dysfunction by inducing neutrophilia |
| topic | B lymphocytes vascular function neutrophil granulocytes nitric oxide |
| url | https://www.mdpi.com/2227-9059/9/11/1686 |
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