Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study
Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clar...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/22/7133 |
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| author | Antonio Ballesteros-Sánchez Jorge Peraza-Nieves Anna Casablanca-Piñera Marina Rodríguez-Calvo-De-Mora Saray Catalán-Coronado Josep Torras-Sanvicens Davide Borroni José-María Sánchez-González Carlos Rocha-De-Lossada |
| author_facet | Antonio Ballesteros-Sánchez Jorge Peraza-Nieves Anna Casablanca-Piñera Marina Rodríguez-Calvo-De-Mora Saray Catalán-Coronado Josep Torras-Sanvicens Davide Borroni José-María Sánchez-González Carlos Rocha-De-Lossada |
| author_sort | Antonio Ballesteros-Sánchez |
| collection | DOAJ |
| description | Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CD<sub>central</sub>), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CD<sub>I,II,III,IV,V,VI</sub>). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (<i>p</i> < 0.001). In addition, the DMEK group showed significantly lower CD<sub>Central,I,II,III,IV,V,VI</sub> values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (<i>p</i> < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (<i>p</i> < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients. |
| first_indexed | 2024-03-09T16:43:15Z |
| format | Article |
| id | doaj.art-ae5f908f0835405c99820f8c2e79e692 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T16:43:15Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ae5f908f0835405c99820f8c2e79e6922023-11-24T14:49:35ZengMDPI AGJournal of Clinical Medicine2077-03832023-11-011222713310.3390/jcm12227133Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative StudyAntonio Ballesteros-Sánchez0Jorge Peraza-Nieves1Anna Casablanca-Piñera2Marina Rodríguez-Calvo-De-Mora3Saray Catalán-Coronado4Josep Torras-Sanvicens5Davide Borroni6José-María Sánchez-González7Carlos Rocha-De-Lossada8Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, SpainAnterior Segment Department, Institut Clinic D’Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, SpainAnterior Segment Department, Institut Clinic D’Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, SpainQvision, Ophthalmology Department, VITHAS Almeria Hospital, 04120 Almeria, SpainAnterior Segment Department, Institut Clinic D’Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, SpainAnterior Segment Department, Institut Clinic D’Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, SpainDepartment of Doctoral Studies, Riga Stradins University, LV-1007 Riga, LatviaDepartment of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, SpainQvision, Ophthalmology Department, VITHAS Almeria Hospital, 04120 Almeria, SpainBackground: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CD<sub>central</sub>), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CD<sub>I,II,III,IV,V,VI</sub>). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (<i>p</i> < 0.001). In addition, the DMEK group showed significantly lower CD<sub>Central,I,II,III,IV,V,VI</sub> values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (<i>p</i> < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (<i>p</i> < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.https://www.mdpi.com/2077-0383/12/22/7133corneal densitometrygraft–host interfaceDescemet Membrane Endothelial Keratoplasty (DMEK)Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) |
| spellingShingle | Antonio Ballesteros-Sánchez Jorge Peraza-Nieves Anna Casablanca-Piñera Marina Rodríguez-Calvo-De-Mora Saray Catalán-Coronado Josep Torras-Sanvicens Davide Borroni José-María Sánchez-González Carlos Rocha-De-Lossada Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study Journal of Clinical Medicine corneal densitometry graft–host interface Descemet Membrane Endothelial Keratoplasty (DMEK) Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) |
| title | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
| title_full | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
| title_fullStr | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
| title_full_unstemmed | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
| title_short | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
| title_sort | scheimpflug corneal densitometry patterns at the graft host interface in dmek and dsaek a 12 month longitudinal comparative study |
| topic | corneal densitometry graft–host interface Descemet Membrane Endothelial Keratoplasty (DMEK) Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) |
| url | https://www.mdpi.com/2077-0383/12/22/7133 |
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