Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight.
Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to immune evasion has been established. A first study conducted in Benin has shown that the production of soluble HLA-G (sHLA-G...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5293225?pdf=render |
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| author | Tania C d'Almeida Ibrahim Sadissou Jacqueline Milet Gilles Cottrell Amandine Mondière Euripide Avokpaho Laure Gineau Audrey Sabbagh Achille Massougbodji Kabirou Moutairou Eduardo A Donadi Benoit Favier Edgardo Carosella Philippe Moreau Nathalie Rouas-Freiss David Courtin André Garcia |
| author_facet | Tania C d'Almeida Ibrahim Sadissou Jacqueline Milet Gilles Cottrell Amandine Mondière Euripide Avokpaho Laure Gineau Audrey Sabbagh Achille Massougbodji Kabirou Moutairou Eduardo A Donadi Benoit Favier Edgardo Carosella Philippe Moreau Nathalie Rouas-Freiss David Courtin André Garcia |
| author_sort | Tania C d'Almeida |
| collection | DOAJ |
| description | Human leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to immune evasion has been established. A first study conducted in Benin has shown that the production of soluble HLA-G (sHLA-G) during the first months of life is strongly correlated with the maternal level at delivery and associated with low birth weight and malaria. However sHLA-G measurements during pregnancy were not available for mothers and furthermore, to date the evolution of sHLA-G in pregnancy is not documented in African populations. To extend these previous findings, between January 2010 and June 2013, 400 pregnant women of a malaria preventive trial and their newborns were followed up in Benin until the age of 2 years. Soluble HLA-G was measured 3 times during pregnancy and repeatedly during the 2 years follow-up to explore how sHLA-G evolved and the factors associated. During pregnancy, plasma levels of sHLA-G remained stable and increased significantly at delivery (p<0.001). Multigravid women seemed to have the highest levels (p = 0.039). In infants, the level was highest in cord blood and decreased before stabilizing after 18 months (p<0.001). For children, a high level of sHLA-G was associated with malaria infection during the follow-up (p = 0.02) and low birth weight (p = 0.06). The mean level of sHLA-G during infancy was strongly correlated with the mother's level during pregnancy (<0.001), and not only at delivery. Moreover, mothers with placental malaria infection had a higher probability of giving birth to a child with a high level of sHLA-g (p = 0.006). High sHLA-G levels during pregnancy might be associated with immune tolerance related to placental malaria. Further studies are needed but this study provides a first insight concerning the potential role of sHLA-G as a biomarker of weakness for newborns and infants. |
| first_indexed | 2024-12-13T11:23:37Z |
| format | Article |
| id | doaj.art-ae61853a58de4acd9f0aa257e1fca9a8 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T11:23:37Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ae61853a58de4acd9f0aa257e1fca9a82022-12-21T23:48:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017111710.1371/journal.pone.0171117Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight.Tania C d'AlmeidaIbrahim SadissouJacqueline MiletGilles CottrellAmandine MondièreEuripide AvokpahoLaure GineauAudrey SabbaghAchille MassougbodjiKabirou MoutairouEduardo A DonadiBenoit FavierEdgardo CarosellaPhilippe MoreauNathalie Rouas-FreissDavid CourtinAndré GarciaHuman leukocyte antigen (HLA) G is a tolerogenic molecule involved in the maternal-fetal immune tolerance phenomenon. Its expression during some infectious diseases leading to immune evasion has been established. A first study conducted in Benin has shown that the production of soluble HLA-G (sHLA-G) during the first months of life is strongly correlated with the maternal level at delivery and associated with low birth weight and malaria. However sHLA-G measurements during pregnancy were not available for mothers and furthermore, to date the evolution of sHLA-G in pregnancy is not documented in African populations. To extend these previous findings, between January 2010 and June 2013, 400 pregnant women of a malaria preventive trial and their newborns were followed up in Benin until the age of 2 years. Soluble HLA-G was measured 3 times during pregnancy and repeatedly during the 2 years follow-up to explore how sHLA-G evolved and the factors associated. During pregnancy, plasma levels of sHLA-G remained stable and increased significantly at delivery (p<0.001). Multigravid women seemed to have the highest levels (p = 0.039). In infants, the level was highest in cord blood and decreased before stabilizing after 18 months (p<0.001). For children, a high level of sHLA-G was associated with malaria infection during the follow-up (p = 0.02) and low birth weight (p = 0.06). The mean level of sHLA-G during infancy was strongly correlated with the mother's level during pregnancy (<0.001), and not only at delivery. Moreover, mothers with placental malaria infection had a higher probability of giving birth to a child with a high level of sHLA-g (p = 0.006). High sHLA-G levels during pregnancy might be associated with immune tolerance related to placental malaria. Further studies are needed but this study provides a first insight concerning the potential role of sHLA-G as a biomarker of weakness for newborns and infants.http://europepmc.org/articles/PMC5293225?pdf=render |
| spellingShingle | Tania C d'Almeida Ibrahim Sadissou Jacqueline Milet Gilles Cottrell Amandine Mondière Euripide Avokpaho Laure Gineau Audrey Sabbagh Achille Massougbodji Kabirou Moutairou Eduardo A Donadi Benoit Favier Edgardo Carosella Philippe Moreau Nathalie Rouas-Freiss David Courtin André Garcia Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. PLoS ONE |
| title | Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. |
| title_full | Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. |
| title_fullStr | Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. |
| title_full_unstemmed | Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. |
| title_short | Soluble human leukocyte antigen -G during pregnancy and infancy in Benin: Mother/child resemblance and association with the risk of malaria infection and low birth weight. |
| title_sort | soluble human leukocyte antigen g during pregnancy and infancy in benin mother child resemblance and association with the risk of malaria infection and low birth weight |
| url | http://europepmc.org/articles/PMC5293225?pdf=render |
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