Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents
Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)- -based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapat...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2019-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900092S.pdf |
| _version_ | 1818136266317758464 |
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| author | Stevanović Milena Đošić Marija Janković Ana Rhee Kyong Yop Mišković-Stanković Vesna |
| author_facet | Stevanović Milena Đošić Marija Janković Ana Rhee Kyong Yop Mišković-Stanković Vesna |
| author_sort | Stevanović Milena |
| collection | DOAJ |
| description | Increasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)- -based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. II45019] |
| first_indexed | 2024-12-11T09:37:40Z |
| format | Article |
| id | doaj.art-ae626e9a7eee4f8aa10697af0d7e62f5 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-11T09:37:40Z |
| publishDate | 2019-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-ae626e9a7eee4f8aa10697af0d7e62f52022-12-22T01:12:48ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212019-01-0184111287130410.2298/JSC190821092S0352-51391900092SElectrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agentsStevanović Milena0Đošić Marija1Janković Ana2Rhee Kyong Yop3Mišković-Stanković Vesna4Faculty of Technology and Metallurgy, University of Belgrade, Belgrade, SerbiaInstitute for Technology of Nuclear and Other Mineral Raw Materials (ITNMS), Belgrade, SerbiaFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, SerbiaDepartment of Mechanical Engineering, Kyung Hee University, Yongin, South KoreaFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, SerbiaIncreasing need for improved, compatible bone tissue implants led to the intensive research of novel biomaterials, especially hydroxyapatite (HAP)- -based composite materials on titanium and titanium alloy surfaces. Owing to its excellent biocompatibility and osteoinductivity properties, hydroxyapatite is often used as part of composite biomaterials aimed for orthopedic implant applications. In order to overcome persistent problems of bacterial infection, various antimicrobial agents and materials and their incorporation in such medical devices were investigated. This paper represents a comprehensive review of single-step electrodeposition on titanium of hydroxyapatite/chitosan/graphene composite coatings loaded with silver and antibiotic gentamicin as antibacterial agents. The improvement of mechanical and adhesive properties of deposited composite coatings was achieved by graphene and chitosan addition, while desirable antibacterial properties were introduced by including antibiotic gentamicin and silver. The biocompatibility of electrodeposited HAP and HAP-based composite coatings was evaluated by MTT testing, indicating a non-cytotoxic effect and high potential for future medical use as orthopedic implant coating. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. II45019]http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900092S.pdfelectrophoretic depositioncompositehydroxyapatitebone implantsantibacterial coating |
| spellingShingle | Stevanović Milena Đošić Marija Janković Ana Rhee Kyong Yop Mišković-Stanković Vesna Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents Journal of the Serbian Chemical Society electrophoretic deposition composite hydroxyapatite bone implants antibacterial coating |
| title | Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents |
| title_full | Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents |
| title_fullStr | Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents |
| title_full_unstemmed | Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents |
| title_short | Electrophoretically deposited hydroxyapatite-based composite coatings loaded with silver and gentamicin as antibacterial agents |
| title_sort | electrophoretically deposited hydroxyapatite based composite coatings loaded with silver and gentamicin as antibacterial agents |
| topic | electrophoretic deposition composite hydroxyapatite bone implants antibacterial coating |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2019/0352-51391900092S.pdf |
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