Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus
Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-11-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/54350 |
| _version_ | 1828195490708062208 |
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| author | Tenzin Ngodup Gabriel E Romero Laurence O Trussell |
| author_facet | Tenzin Ngodup Gabriel E Romero Laurence O Trussell |
| author_sort | Tenzin Ngodup |
| collection | DOAJ |
| description | Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse line, optical clearing, and imaging techniques, combined with electrophysiological tools, we revealed a population of glycinergic cells in the VCN distinct from the D-stellate cell. These multipolar glycinergic cells were smaller in soma size and dendritic area, but over ten-fold more numerous than D-stellate cells. They were activated by auditory nerve and T-stellate cells, and made local inhibitory synaptic contacts on principal cells of the VCN. Given their abundance, combined with their narrow dendritic fields and axonal projections, it is likely that these neurons, here termed L-stellate cells, play a significant role in frequency-specific processing of acoustic signals. |
| first_indexed | 2024-04-12T09:44:35Z |
| format | Article |
| id | doaj.art-ae653638f2c9436882698a6ae1f1c5be |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:44:35Z |
| publishDate | 2020-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ae653638f2c9436882698a6ae1f1c5be2022-12-22T03:37:59ZengeLife Sciences Publications LtdeLife2050-084X2020-11-01910.7554/eLife.54350Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleusTenzin Ngodup0Gabriel E Romero1Laurence O Trussell2https://orcid.org/0000-0003-1171-2356Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, United StatesPhysiology and Pharmacology Graduate Program, Oregon Health and Science University, Portland, United StatesOregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, United StatesAuditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neuron termed the D-stellate cell. With the use of a transgenic mouse line, optical clearing, and imaging techniques, combined with electrophysiological tools, we revealed a population of glycinergic cells in the VCN distinct from the D-stellate cell. These multipolar glycinergic cells were smaller in soma size and dendritic area, but over ten-fold more numerous than D-stellate cells. They were activated by auditory nerve and T-stellate cells, and made local inhibitory synaptic contacts on principal cells of the VCN. Given their abundance, combined with their narrow dendritic fields and axonal projections, it is likely that these neurons, here termed L-stellate cells, play a significant role in frequency-specific processing of acoustic signals.https://elifesciences.org/articles/54350auditorycell typesglycinecochlear nucleus |
| spellingShingle | Tenzin Ngodup Gabriel E Romero Laurence O Trussell Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus eLife auditory cell types glycine cochlear nucleus |
| title | Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus |
| title_full | Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus |
| title_fullStr | Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus |
| title_full_unstemmed | Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus |
| title_short | Identification of an inhibitory neuron subtype, the L-stellate cell of the cochlear nucleus |
| title_sort | identification of an inhibitory neuron subtype the l stellate cell of the cochlear nucleus |
| topic | auditory cell types glycine cochlear nucleus |
| url | https://elifesciences.org/articles/54350 |
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