RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy
Little is known about how proteostasis is maintained during viral infection. Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33805-9 |
| _version_ | 1811182303787876352 |
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| author | Jing Zhang Bin Wang Xiaoxiao Gao Cheng Peng Chao Shan Silas F. Johnson Richard C. Schwartz Yong-Hui Zheng |
| author_facet | Jing Zhang Bin Wang Xiaoxiao Gao Cheng Peng Chao Shan Silas F. Johnson Richard C. Schwartz Yong-Hui Zheng |
| author_sort | Jing Zhang |
| collection | DOAJ |
| description | Little is known about how proteostasis is maintained during viral infection. Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression. |
| first_indexed | 2024-04-11T09:30:29Z |
| format | Article |
| id | doaj.art-ae65b909852c47fabd4f56d608918dcc |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T09:30:29Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ae65b909852c47fabd4f56d608918dcc2022-12-22T04:31:55ZengNature PortfolioNature Communications2041-17232022-10-0113111810.1038/s41467-022-33805-9RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagyJing Zhang0Bin Wang1Xiaoxiao Gao2Cheng Peng3Chao Shan4Silas F. Johnson5Richard C. Schwartz6Yong-Hui Zheng7Harbin Veterinary Research Institute, CAAS-Michigan State University Joint Laboratory of Innate Immunity, State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural SciencesHarbin Veterinary Research Institute, CAAS-Michigan State University Joint Laboratory of Innate Immunity, State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural SciencesCenter for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of SciencesCenter for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of SciencesCenter for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of SciencesDepartment of Microbiology and Molecular Genetics, Michigan State UniversityDepartment of Microbiology and Molecular Genetics, Michigan State UniversityHarbin Veterinary Research Institute, CAAS-Michigan State University Joint Laboratory of Innate Immunity, State Key Laboratory of Veterinary Biotechnology, Chinese Academy of Agricultural SciencesLittle is known about how proteostasis is maintained during viral infection. Here, the authors identify unexpected crosstalk between the calnexin cycle, ERAD, and reticulophagy, resulting in suppression of ebolavirus glycoprotein expression.https://doi.org/10.1038/s41467-022-33805-9 |
| spellingShingle | Jing Zhang Bin Wang Xiaoxiao Gao Cheng Peng Chao Shan Silas F. Johnson Richard C. Schwartz Yong-Hui Zheng RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy Nature Communications |
| title | RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy |
| title_full | RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy |
| title_fullStr | RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy |
| title_full_unstemmed | RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy |
| title_short | RNF185 regulates proteostasis in Ebolavirus infection by crosstalk between the calnexin cycle, ERAD, and reticulophagy |
| title_sort | rnf185 regulates proteostasis in ebolavirus infection by crosstalk between the calnexin cycle erad and reticulophagy |
| url | https://doi.org/10.1038/s41467-022-33805-9 |
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