Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso
Severe acute malnutrition (SAM) is treated with ready-to-use therapeutic foods (RUTF) containing a vitamin–mineral premix. Yet little is known about micronutrient status in children with SAM before and after treatment. We aimed to investigate vitamin B12 status in children with uncomplicated SAM, ag...
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MDPI AG
2023-08-01
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| Online Access: | https://www.mdpi.com/2072-6643/15/16/3496 |
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| author | Victor Nikièma Suvi T. Kangas Cécile Salpeteur André Briend Leisel Talley Henrik Friis Christian Ritz Ebba Nexo Adrian McCann |
| author_facet | Victor Nikièma Suvi T. Kangas Cécile Salpeteur André Briend Leisel Talley Henrik Friis Christian Ritz Ebba Nexo Adrian McCann |
| author_sort | Victor Nikièma |
| collection | DOAJ |
| description | Severe acute malnutrition (SAM) is treated with ready-to-use therapeutic foods (RUTF) containing a vitamin–mineral premix. Yet little is known about micronutrient status in children with SAM before and after treatment. We aimed to investigate vitamin B12 status in children with uncomplicated SAM, aged 6–59 months in Burkina Faso, before and after treatment with a standard or a reduced dose of RUTF. Blood samples were collected at admission and discharge. Serum B12 was determined with microbiological assay and serum methylmalonic acid (MMA) and total homocysteine (tHcy) were analyzed with gas chromatography-tandem mass spectrometry. B12 status was classified using the combined indicator (3cB12). Among 374 children, the median [interquartile range] age was 11.0 [7.7–16.9] months, and 85.8% were breastfed. Marked or severe B12 deficiency, as judged by 3cB12, decreased from 32% to 9% between admission and discharge (<i>p</i> < 0.05). No differences in B12 status following treatment with either standard (<i>n</i> = 194) or reduced (<i>n</i> = 180) doses of RUTF were observed. Breastfed children showed a lower B12 status (3cB12) than non-breastfed ones (−1.10 vs −0.18, <i>p</i> < 0.001 at admission; −0.44 vs 0.19; <i>p</i> < 0.001 at discharge). In conclusion, treatment of SAM with RUTF improved children’s B12 status but did not fully correct B12 deficiency. |
| first_indexed | 2024-03-10T23:40:47Z |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:40:47Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ae67c7785a3e471ba2b74d4e06580b3a2023-11-19T02:28:36ZengMDPI AGNutrients2072-66432023-08-011516349610.3390/nu15163496Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina FasoVictor Nikièma0Suvi T. Kangas1Cécile Salpeteur2André Briend3Leisel Talley4Henrik Friis5Christian Ritz6Ebba Nexo7Adrian McCann8Expertise and Advocacy Department, Action Against Hunger (ACF), 93558 Montreuil, FranceAirbel Impact Lab, International Rescue Committee, New York, NY 10168, USAExpertise and Advocacy Department, Action Against Hunger (ACF), 93558 Montreuil, FranceDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 1958 Copenhagen, DenmarkCenters for Disease Control and Prevention, Atlanta, GA 30329, USADepartment of Nutrition, Exercise and Sports, University of Copenhagen, 1958 Copenhagen, DenmarkDepartment of Nutrition, Exercise and Sports, University of Copenhagen, 1958 Copenhagen, DenmarkDepartment of Clinical Biochemistry, Aarhus University Hospital, 8200 Aarhus, DenmarkBevital AS, 5021 Bergen, NorwaySevere acute malnutrition (SAM) is treated with ready-to-use therapeutic foods (RUTF) containing a vitamin–mineral premix. Yet little is known about micronutrient status in children with SAM before and after treatment. We aimed to investigate vitamin B12 status in children with uncomplicated SAM, aged 6–59 months in Burkina Faso, before and after treatment with a standard or a reduced dose of RUTF. Blood samples were collected at admission and discharge. Serum B12 was determined with microbiological assay and serum methylmalonic acid (MMA) and total homocysteine (tHcy) were analyzed with gas chromatography-tandem mass spectrometry. B12 status was classified using the combined indicator (3cB12). Among 374 children, the median [interquartile range] age was 11.0 [7.7–16.9] months, and 85.8% were breastfed. Marked or severe B12 deficiency, as judged by 3cB12, decreased from 32% to 9% between admission and discharge (<i>p</i> < 0.05). No differences in B12 status following treatment with either standard (<i>n</i> = 194) or reduced (<i>n</i> = 180) doses of RUTF were observed. Breastfed children showed a lower B12 status (3cB12) than non-breastfed ones (−1.10 vs −0.18, <i>p</i> < 0.001 at admission; −0.44 vs 0.19; <i>p</i> < 0.001 at discharge). In conclusion, treatment of SAM with RUTF improved children’s B12 status but did not fully correct B12 deficiency.https://www.mdpi.com/2072-6643/15/16/3496childrensevere acute malnutritionready-to-use therapeutic foodsserum B12combined indicator of B12 statusBurkina Faso |
| spellingShingle | Victor Nikièma Suvi T. Kangas Cécile Salpeteur André Briend Leisel Talley Henrik Friis Christian Ritz Ebba Nexo Adrian McCann Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso Nutrients children severe acute malnutrition ready-to-use therapeutic foods serum B12 combined indicator of B12 status Burkina Faso |
| title | Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso |
| title_full | Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso |
| title_fullStr | Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso |
| title_full_unstemmed | Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso |
| title_short | Vitamin B12 Status before and after Outpatient Treatment of Severe Acute Malnutrition in Children Aged 6–59 Months: A Sub-Study of a Randomized Controlled Trial in Burkina Faso |
| title_sort | vitamin b12 status before and after outpatient treatment of severe acute malnutrition in children aged 6 59 months a sub study of a randomized controlled trial in burkina faso |
| topic | children severe acute malnutrition ready-to-use therapeutic foods serum B12 combined indicator of B12 status Burkina Faso |
| url | https://www.mdpi.com/2072-6643/15/16/3496 |
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