Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies
Abstract Background Endothelium function is often impaired in patients with type 2 diabetes. We hypothesized that by improving endothelial function using diastole-synchronized compressions/decompressions (DSCD) to the lower body may improve the metabolic profile. The objective of this research was t...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-022-01710-6 |
| _version_ | 1797977607564689408 |
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| author | Paul Valensi Nicolas Barber-Chamoux Amel Rezki Céline Lambert Bruno Pereira Christian Dualé Dominique Delmas Martine Duclos |
| author_facet | Paul Valensi Nicolas Barber-Chamoux Amel Rezki Céline Lambert Bruno Pereira Christian Dualé Dominique Delmas Martine Duclos |
| author_sort | Paul Valensi |
| collection | DOAJ |
| description | Abstract Background Endothelium function is often impaired in patients with type 2 diabetes. We hypothesized that by improving endothelial function using diastole-synchronized compressions/decompressions (DSCD) to the lower body may improve the metabolic profile. The objective of this research was to evaluate the effects of single and multiple DSCD sessions on microcirculation, endothelium function and metabolic parameters of patients with type 2 diabetes. Methods Two monocentric, controlled, randomized cross-over studies (Study 1 and Study 2) were performed. In Study 1, 16 patients received one 20 min DSCD and one simulated (control) session at 2 week intervals; continuous glucose monitoring and cutaneous blood flow were recorded continuously before, during and after DSCD or Control session; other vascular assessments were performed before and after DSCD and control sessions. In Study 2, 38 patients received 60 min DSCD sessions three times/week for three months followed by a 4–6 week washout and 3 month control period (without simulated sessions); vascular, metabolic, body composition, physical activity and quality of life assessments were performed before and after 3 months. Results Both studies showed significant, multiplex effects of DSCD sessions. In Study 1, cutaneous blood flow and endothelium function increased, and plasma and interstitial glucose levels after a standard breakfast decreased after DSCD sessions. In Study 2, cutaneous endothelium function improved, LDL-cholesterol and non-HDL cholesterol decreased, extra-cell water decreased and SF-36 Vitality score increased after 3 months of DSCD sessions. Conclusions Our findings support the beneficial effect of DSCD on the endothelium and show concomitant beneficial metabolic and vitality effects. Future clinical trials need to test whether DSCD use translates into a preventive measure against microvascular diabetic complications and its progression. Trial registration ClinicalTrials.gov identifiers: NCT02293135 and NCT02359461. |
| first_indexed | 2024-04-11T05:09:57Z |
| format | Article |
| id | doaj.art-ae6951630abe4c24ac136469542b7e3f |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-04-11T05:09:57Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-ae6951630abe4c24ac136469542b7e3f2022-12-25T12:04:30ZengBMCCardiovascular Diabetology1475-28402022-12-0121111610.1186/s12933-022-01710-6Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studiesPaul Valensi0Nicolas Barber-Chamoux1Amel Rezki2Céline Lambert3Bruno Pereira4Christian Dualé5Dominique Delmas6Martine Duclos7Endocrinology, Diabetology and Nutrition Unit, AP-HP, Jean Verdier Hospital, Sorbonne Paris Nord University, CRNH-IdF, CINFODepartment of Cardiology, CHU Clermont-FerrandEndocrinology, Diabetology and Nutrition Unit, AP-HP, Jean Verdier Hospital, Sorbonne Paris Nord University, CRNH-IdF, CINFOBiostatistics Unit, DRCI, CHU Clermont-FerrandBiostatistics Unit, DRCI, CHU Clermont-FerrandClinical Investigation Center (INSERM CIC1405), CHU Clermont-FerrandSESAME SASDepartment of Sports Medicine and Functional Explorations, CHU Clermont-Ferrand, INRAE, UNH, CRNH Auvergne, Clermont Auvergne UniversityAbstract Background Endothelium function is often impaired in patients with type 2 diabetes. We hypothesized that by improving endothelial function using diastole-synchronized compressions/decompressions (DSCD) to the lower body may improve the metabolic profile. The objective of this research was to evaluate the effects of single and multiple DSCD sessions on microcirculation, endothelium function and metabolic parameters of patients with type 2 diabetes. Methods Two monocentric, controlled, randomized cross-over studies (Study 1 and Study 2) were performed. In Study 1, 16 patients received one 20 min DSCD and one simulated (control) session at 2 week intervals; continuous glucose monitoring and cutaneous blood flow were recorded continuously before, during and after DSCD or Control session; other vascular assessments were performed before and after DSCD and control sessions. In Study 2, 38 patients received 60 min DSCD sessions three times/week for three months followed by a 4–6 week washout and 3 month control period (without simulated sessions); vascular, metabolic, body composition, physical activity and quality of life assessments were performed before and after 3 months. Results Both studies showed significant, multiplex effects of DSCD sessions. In Study 1, cutaneous blood flow and endothelium function increased, and plasma and interstitial glucose levels after a standard breakfast decreased after DSCD sessions. In Study 2, cutaneous endothelium function improved, LDL-cholesterol and non-HDL cholesterol decreased, extra-cell water decreased and SF-36 Vitality score increased after 3 months of DSCD sessions. Conclusions Our findings support the beneficial effect of DSCD on the endothelium and show concomitant beneficial metabolic and vitality effects. Future clinical trials need to test whether DSCD use translates into a preventive measure against microvascular diabetic complications and its progression. Trial registration ClinicalTrials.gov identifiers: NCT02293135 and NCT02359461.https://doi.org/10.1186/s12933-022-01710-6Type 2 diabetesEndothelial functionShear stressPulsating compressionsMetabolic effects |
| spellingShingle | Paul Valensi Nicolas Barber-Chamoux Amel Rezki Céline Lambert Bruno Pereira Christian Dualé Dominique Delmas Martine Duclos Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies Cardiovascular Diabetology Type 2 diabetes Endothelial function Shear stress Pulsating compressions Metabolic effects |
| title | Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies |
| title_full | Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies |
| title_fullStr | Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies |
| title_full_unstemmed | Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies |
| title_short | Effects of single and multiple sessions of lower body diastole-synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes: two controlled cross-over studies |
| title_sort | effects of single and multiple sessions of lower body diastole synchronized compressions using a pulsating pneumatic suit on endothelium function and metabolic parameters in patients with type 2 diabetes two controlled cross over studies |
| topic | Type 2 diabetes Endothelial function Shear stress Pulsating compressions Metabolic effects |
| url | https://doi.org/10.1186/s12933-022-01710-6 |
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