Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers.
Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never expe...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3817120?pdf=render |
| _version_ | 1811238080312508416 |
|---|---|
| author | Philippe Connes Yann Lamarre Marie-Dominique Hardy-Dessources Nathalie Lemonne Xavier Waltz Danièle Mougenel Martin Mukisi-Mukaza Marie-Laure Lalanne-Mistrih Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marc Romana |
| author_facet | Philippe Connes Yann Lamarre Marie-Dominique Hardy-Dessources Nathalie Lemonne Xavier Waltz Danièle Mougenel Martin Mukisi-Mukaza Marie-Laure Lalanne-Mistrih Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marc Romana |
| author_sort | Philippe Connes |
| collection | DOAJ |
| description | Leg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (ULC+)--with no leg ulcers at the time of the study--were recruited. All patients were in steady state condition. Blood was sampled to perform hematological, biochemical (hemolytic markers) and hemorheological analyses (blood viscosity, red blood cell deformability and aggregation properties). The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each subject. Patients from the ULC+ group were older than patients from the ULC- group. Anemia (red blood cell count, hematocrit and hemoglobin levels) was more pronounced in the ULC+ group. Lactate dehydrogenase level was higher in the ULC+ group than in the ULC- group. Neither blood viscosity, nor RBC aggregation properties differed between the two groups. HVR was lower and RBC deformability tended to be reduced in the ULC+ group. Our study confirmed increased hemolytic rate and anemia in SCA patients with leg ulcers recurrence. Furthermore, our data suggest that although systemic blood viscosity is not a major factor involved in the pathophysiology of this complication, decreased red blood cell oxygen transport efficiency (i.e., low hematocrit/viscosity ratio) may play a role. |
| first_indexed | 2024-04-12T12:35:19Z |
| format | Article |
| id | doaj.art-ae698f82a78f47c3be5bb05d1879fee9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T12:35:19Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ae698f82a78f47c3be5bb05d1879fee92022-12-22T03:32:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e7968010.1371/journal.pone.0079680Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers.Philippe ConnesYann LamarreMarie-Dominique Hardy-DessourcesNathalie LemonneXavier WaltzDanièle MougenelMartin Mukisi-MukazaMarie-Laure Lalanne-MistrihVanessa TarerBenoit TressièresMaryse Etienne-JulanMarc RomanaLeg ulcer is a disabling complication in patients with sickle cell anemia (SCA) but the exact pathophysiological mechanisms are unknown. The aim of this study was to identify the hematological and hemorheological alterations associated with recurrent leg ulcers. Sixty-two SCA patients who never experienced leg ulcers (ULC-) and 13 SCA patients with a positive history of recurrent leg ulcers (ULC+)--with no leg ulcers at the time of the study--were recruited. All patients were in steady state condition. Blood was sampled to perform hematological, biochemical (hemolytic markers) and hemorheological analyses (blood viscosity, red blood cell deformability and aggregation properties). The hematocrit-to-viscosity ratio (HVR), which reflects the red blood cell oxygen transport efficiency, was calculated for each subject. Patients from the ULC+ group were older than patients from the ULC- group. Anemia (red blood cell count, hematocrit and hemoglobin levels) was more pronounced in the ULC+ group. Lactate dehydrogenase level was higher in the ULC+ group than in the ULC- group. Neither blood viscosity, nor RBC aggregation properties differed between the two groups. HVR was lower and RBC deformability tended to be reduced in the ULC+ group. Our study confirmed increased hemolytic rate and anemia in SCA patients with leg ulcers recurrence. Furthermore, our data suggest that although systemic blood viscosity is not a major factor involved in the pathophysiology of this complication, decreased red blood cell oxygen transport efficiency (i.e., low hematocrit/viscosity ratio) may play a role.http://europepmc.org/articles/PMC3817120?pdf=render |
| spellingShingle | Philippe Connes Yann Lamarre Marie-Dominique Hardy-Dessources Nathalie Lemonne Xavier Waltz Danièle Mougenel Martin Mukisi-Mukaza Marie-Laure Lalanne-Mistrih Vanessa Tarer Benoit Tressières Maryse Etienne-Julan Marc Romana Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. PLoS ONE |
| title | Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. |
| title_full | Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. |
| title_fullStr | Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. |
| title_full_unstemmed | Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. |
| title_short | Decreased hematocrit-to-viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers. |
| title_sort | decreased hematocrit to viscosity ratio and increased lactate dehydrogenase level in patients with sickle cell anemia and recurrent leg ulcers |
| url | http://europepmc.org/articles/PMC3817120?pdf=render |
| work_keys_str_mv | AT philippeconnes decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT yannlamarre decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT mariedominiquehardydessources decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT nathalielemonne decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT xavierwaltz decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT danielemougenel decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT martinmukisimukaza decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT marielaurelalannemistrih decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT vanessatarer decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT benoittressieres decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT maryseetiennejulan decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers AT marcromana decreasedhematocrittoviscosityratioandincreasedlactatedehydrogenaselevelinpatientswithsicklecellanemiaandrecurrentlegulcers |