A review of glyphosate application: the health-related effect
Introduction and purpose The glyphosate (GLY) is a systemic herbicide and cropp desiccant registered for use in more than 130 countries. The herbicide is applied to control more than 160 weeds. Despite the declarations about complete biodegradability of herbicide, is difficult to complete eliminati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2019-09-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/27393 |
| _version_ | 1818010514135973888 |
|---|---|
| author | Joanna Rog Paulina Wróbel-Knybel |
| author_facet | Joanna Rog Paulina Wróbel-Knybel |
| author_sort | Joanna Rog |
| collection | DOAJ |
| description | Introduction and purpose
The glyphosate (GLY) is a systemic herbicide and cropp desiccant registered for use in more than 130 countries. The herbicide is applied to control more than 160 weeds. Despite the declarations about complete biodegradability of herbicide, is difficult to complete elimination of it. GLY may affect the activity of cytochrome P450, the gut microbiome and metals chelation and thus have an adverse health effect. The evidence suggests a relationship between the use of GLY and numerous chronic diseases. The aim of this paper was to review the available literature that examined the health-related effect of GLY.
The state of knowledge
Numerous studies have confirmed the adverse effects of GLY on health. GLY injection in high dose initiate processes involved in cancerogenesis. In human studies, the GLY use was related with 41% higher risk of non-Hodgkin's lymphoma. GLY can lead to endocrine changes, including corticosterone levels and steroidogenesis. In pregnant women population, the higher GLY concentrations in urine were related with shorter pregnancy length. GLY could affects gut microbiome and leading to the development of intestinal dysbiosis, gut-brain axis and central nervous system changes. The formulated complexes GLY-minerals may damage nephrons. The nephrotoxic effect of herbicide was confirmed in human studies.
Conclusions
Most of the studies assessed the short term health-related effect of GLY. Obtained results do not reflect the environmental exposure which lasting many years. There is an urgent need to assess the long term effect of GLY in small doses in high-quality epidemiological studies. |
| first_indexed | 2024-04-14T05:56:19Z |
| format | Article |
| id | doaj.art-ae6a34b4d9004a4c8ccac5a5b030aa7e |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-14T05:56:19Z |
| publishDate | 2019-09-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-ae6a34b4d9004a4c8ccac5a5b030aa7e2022-12-22T02:08:55ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-09-0199A review of glyphosate application: the health-related effectJoanna Rog0Paulina Wróbel-Knybel11st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin1st Department of Psychiatry, Psychotherapy and Early Intervention, Medical University of LublinIntroduction and purpose The glyphosate (GLY) is a systemic herbicide and cropp desiccant registered for use in more than 130 countries. The herbicide is applied to control more than 160 weeds. Despite the declarations about complete biodegradability of herbicide, is difficult to complete elimination of it. GLY may affect the activity of cytochrome P450, the gut microbiome and metals chelation and thus have an adverse health effect. The evidence suggests a relationship between the use of GLY and numerous chronic diseases. The aim of this paper was to review the available literature that examined the health-related effect of GLY. The state of knowledge Numerous studies have confirmed the adverse effects of GLY on health. GLY injection in high dose initiate processes involved in cancerogenesis. In human studies, the GLY use was related with 41% higher risk of non-Hodgkin's lymphoma. GLY can lead to endocrine changes, including corticosterone levels and steroidogenesis. In pregnant women population, the higher GLY concentrations in urine were related with shorter pregnancy length. GLY could affects gut microbiome and leading to the development of intestinal dysbiosis, gut-brain axis and central nervous system changes. The formulated complexes GLY-minerals may damage nephrons. The nephrotoxic effect of herbicide was confirmed in human studies. Conclusions Most of the studies assessed the short term health-related effect of GLY. Obtained results do not reflect the environmental exposure which lasting many years. There is an urgent need to assess the long term effect of GLY in small doses in high-quality epidemiological studies.https://apcz.umk.pl/JEHS/article/view/27393GlyphosateRoundupCancerogenesisMicrobial communityEndocrine disruptionGut-brain axis |
| spellingShingle | Joanna Rog Paulina Wróbel-Knybel A review of glyphosate application: the health-related effect Journal of Education, Health and Sport Glyphosate Roundup Cancerogenesis Microbial community Endocrine disruption Gut-brain axis |
| title | A review of glyphosate application: the health-related effect |
| title_full | A review of glyphosate application: the health-related effect |
| title_fullStr | A review of glyphosate application: the health-related effect |
| title_full_unstemmed | A review of glyphosate application: the health-related effect |
| title_short | A review of glyphosate application: the health-related effect |
| title_sort | review of glyphosate application the health related effect |
| topic | Glyphosate Roundup Cancerogenesis Microbial community Endocrine disruption Gut-brain axis |
| url | https://apcz.umk.pl/JEHS/article/view/27393 |
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