Fertility preservation outcomes may differ by cancer diagnosis
Context : Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients. Aims : To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis. Settings...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=111;epage=118;aulast=Pavone |
| _version_ | 1818950752456933376 |
|---|---|
| author | Mary Ellen Pavone Jennifer Hirshfeld-Cytron Angela K Lawson Kristin Smith Ralph Kazer Susan Klock |
| author_facet | Mary Ellen Pavone Jennifer Hirshfeld-Cytron Angela K Lawson Kristin Smith Ralph Kazer Susan Klock |
| author_sort | Mary Ellen Pavone |
| collection | DOAJ |
| description | Context : Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients. Aims : To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis. Settings and Deign : Between 2005 and 2011, 109 patients elected to pursue FP at a single institution. Materials and Method : In vitro fertilization (IVF) outcome variables between four cancer diagnostic groups (breast, gynecologic, lymphoma/leukemia and other) and age-matched male factor or tubal factor infertility IVF control group were compared. Statistical Analysis : ANOVA and Chi-square analyses were employed to compare variables between the groups that were normally distributed. Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed. Results : Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response. Women with hematologic malignancies were most likely to have been exposed to chemotherapy and had the longest stimulations with a similar number of oocytes retrieved. The age-matched IVF controls had higher peak estradiol levels, number of oocytes obtained, and fertilization rates when compared to cancer patients with or without a history of prior chemotherapy. Conclusions : Factors including age, type of cancer and chemotherapy exposure, can influence response to ovarian stimulation. Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations. |
| first_indexed | 2024-12-20T09:23:35Z |
| format | Article |
| id | doaj.art-ae6b86ee18564ed9a0b1f324e6c150d1 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-20T09:23:35Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-ae6b86ee18564ed9a0b1f324e6c150d12022-12-21T19:45:14ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662014-01-017211111810.4103/0974-1208.138869Fertility preservation outcomes may differ by cancer diagnosisMary Ellen PavoneJennifer Hirshfeld-CytronAngela K LawsonKristin SmithRalph KazerSusan KlockContext : Cancer survival has improved significantly and maintaining fertility is both a major concern and an important factor for the quality of life in cancer patients. Aims : To explore differences in oocyte stimulation for fertility preservation (FP) patients based on cancer diagnosis. Settings and Deign : Between 2005 and 2011, 109 patients elected to pursue FP at a single institution. Materials and Method : In vitro fertilization (IVF) outcome variables between four cancer diagnostic groups (breast, gynecologic, lymphoma/leukemia and other) and age-matched male factor or tubal factor infertility IVF control group were compared. Statistical Analysis : ANOVA and Chi-square analyses were employed to compare variables between the groups that were normally distributed. Kruskal-Wallis with subsequent Mann-Whitney U-test were used for data that were not normally distributed. Results : Women with gynecologic malignancies were significantly older than the women in the other three groups, but tended to have a better ovarian response. Women with hematologic malignancies were most likely to have been exposed to chemotherapy and had the longest stimulations with a similar number of oocytes retrieved. The age-matched IVF controls had higher peak estradiol levels, number of oocytes obtained, and fertilization rates when compared to cancer patients with or without a history of prior chemotherapy. Conclusions : Factors including age, type of cancer and chemotherapy exposure, can influence response to ovarian stimulation. Discussing these findings with patients presenting for FP may aid in setting realistic treatment expectations.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=111;epage=118;aulast=PavoneCancercryopreservationfertility preservationin vitro fertilizationoncofertility |
| spellingShingle | Mary Ellen Pavone Jennifer Hirshfeld-Cytron Angela K Lawson Kristin Smith Ralph Kazer Susan Klock Fertility preservation outcomes may differ by cancer diagnosis Journal of Human Reproductive Sciences Cancer cryopreservation fertility preservation in vitro fertilization oncofertility |
| title | Fertility preservation outcomes may differ by cancer diagnosis |
| title_full | Fertility preservation outcomes may differ by cancer diagnosis |
| title_fullStr | Fertility preservation outcomes may differ by cancer diagnosis |
| title_full_unstemmed | Fertility preservation outcomes may differ by cancer diagnosis |
| title_short | Fertility preservation outcomes may differ by cancer diagnosis |
| title_sort | fertility preservation outcomes may differ by cancer diagnosis |
| topic | Cancer cryopreservation fertility preservation in vitro fertilization oncofertility |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2014;volume=7;issue=2;spage=111;epage=118;aulast=Pavone |
| work_keys_str_mv | AT maryellenpavone fertilitypreservationoutcomesmaydifferbycancerdiagnosis AT jenniferhirshfeldcytron fertilitypreservationoutcomesmaydifferbycancerdiagnosis AT angelaklawson fertilitypreservationoutcomesmaydifferbycancerdiagnosis AT kristinsmith fertilitypreservationoutcomesmaydifferbycancerdiagnosis AT ralphkazer fertilitypreservationoutcomesmaydifferbycancerdiagnosis AT susanklock fertilitypreservationoutcomesmaydifferbycancerdiagnosis |