Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature
Perfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1103141/full |
| _version_ | 1797942692031758336 |
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| author | Dongge Liu Shuqi Yan Pingwei Wang Qianqian Chen Yanping Liu Jiajing Cui Yujun Liang Shuping Ren Ying Gao |
| author_facet | Dongge Liu Shuqi Yan Pingwei Wang Qianqian Chen Yanping Liu Jiajing Cui Yujun Liang Shuping Ren Ying Gao |
| author_sort | Dongge Liu |
| collection | DOAJ |
| description | Perfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in the human body, there are increasing concerns about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of Perfluorooctanoic acid, and Perfluorooctanoic acid can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarize the relationship between Perfluorooctanoic acid exposure and kidney health, evaluate risks more clearly, and provide a theoretical basis for subsequent research. |
| first_indexed | 2024-04-10T20:12:38Z |
| format | Article |
| id | doaj.art-ae6cbb3bb33c48418661cfbf19c4868d |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-10T20:12:38Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-ae6cbb3bb33c48418661cfbf19c4868d2023-01-26T09:57:30ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-01-011410.3389/fphys.2023.11031411103141Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literatureDongge Liu0Shuqi Yan1Pingwei Wang2Qianqian Chen3Yanping Liu4Jiajing Cui5Yujun Liang6Shuping Ren7Ying Gao8Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun, ChinaDepartment of Endocrinology, The First Hospital of Jilin University, Changchun, ChinaPerfluorooctanoic acid is an artificial and non-degradable chemical. It is widely used due to its stable nature. It can enter the human body through food, drinking water, inhalation of household dust and contact with products containing perfluorooctanoic acid. It accumulates in the human body, causing potential harmful effects on human health. Based on the biodegradability and bioaccumulation of perfluorooctanoic acid in the human body, there are increasing concerns about the adverse effects of perfluorooctanoic acid exposure on kidneys. Research shows that kidney is the main accumulation organ of Perfluorooctanoic acid, and Perfluorooctanoic acid can cause nephrotoxicity and produce adverse effects on kidney function, but the exact mechanism is still unknown. In this review, we summarize the relationship between Perfluorooctanoic acid exposure and kidney health, evaluate risks more clearly, and provide a theoretical basis for subsequent research.https://www.frontiersin.org/articles/10.3389/fphys.2023.1103141/fullperfluorooctanoic acidkidneypfoaPFASCKDEGFR |
| spellingShingle | Dongge Liu Shuqi Yan Pingwei Wang Qianqian Chen Yanping Liu Jiajing Cui Yujun Liang Shuping Ren Ying Gao Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature Frontiers in Physiology perfluorooctanoic acid kidney pfoa PFAS CKD EGFR |
| title | Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature |
| title_full | Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature |
| title_fullStr | Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature |
| title_full_unstemmed | Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature |
| title_short | Perfluorooctanoic acid (PFOA) exposure in relation to the kidneys: A review of current available literature |
| title_sort | perfluorooctanoic acid pfoa exposure in relation to the kidneys a review of current available literature |
| topic | perfluorooctanoic acid kidney pfoa PFAS CKD EGFR |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1103141/full |
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