Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development
BackgroundIntraoperative hypotension has an adverse impact on postoperative outcomes. However, it is difficult to predict and treat intraoperative hypotension in advance according to individual clinical parameters. ObjectiveThe aim of this study was to develop a p...
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| Format: | Article |
| Language: | English |
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JMIR Publications
2021-09-01
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| Series: | JMIR Medical Informatics |
| Online Access: | https://medinform.jmir.org/2021/9/e31311 |
| _version_ | 1797735686777864192 |
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| author | Sooho Choe Eunjeong Park Wooseok Shin Bonah Koo Dongjin Shin Chulwoo Jung Hyungchul Lee Jeongmin Kim |
| author_facet | Sooho Choe Eunjeong Park Wooseok Shin Bonah Koo Dongjin Shin Chulwoo Jung Hyungchul Lee Jeongmin Kim |
| author_sort | Sooho Choe |
| collection | DOAJ |
| description |
BackgroundIntraoperative hypotension has an adverse impact on postoperative outcomes. However, it is difficult to predict and treat intraoperative hypotension in advance according to individual clinical parameters.
ObjectiveThe aim of this study was to develop a prediction model to forecast 5-minute intraoperative hypotension based on the weighted average ensemble of individual neural networks, utilizing the biosignals recorded during noncardiac surgery.
MethodsIn this retrospective observational study, arterial waveforms were recorded during noncardiac operations performed between August 2016 and December 2019, at Seoul National University Hospital, Seoul, South Korea. We analyzed the arterial waveforms from the big data in the VitalDB repository of electronic health records. We defined 2s hypotension as the moving average of arterial pressure under 65 mmHg for 2 seconds, and intraoperative hypotensive events were defined when the 2s hypotension lasted for at least 60 seconds. We developed an artificial intelligence–enabled process, named short-term event prediction in the operating room (STEP-OP), for predicting short-term intraoperative hypotension.
ResultsThe study was performed on 18,813 subjects undergoing noncardiac surgeries. Deep-learning algorithms (convolutional neural network [CNN] and recurrent neural network [RNN]) using raw waveforms as input showed greater area under the precision-recall curve (AUPRC) scores (0.698, 95% CI 0.690-0.705 and 0.706, 95% CI 0.698-0.715, respectively) than that of the logistic regression algorithm (0.673, 95% CI 0.665-0.682). STEP-OP performed better and had greater AUPRC values than those of the RNN and CNN algorithms (0.716, 95% CI 0.708-0.723).
ConclusionsWe developed STEP-OP as a weighted average of deep-learning models. STEP-OP predicts intraoperative hypotension more accurately than the CNN, RNN, and logistic regression models.
Trial RegistrationClinicalTrials.gov NCT02914444; https://clinicaltrials.gov/ct2/show/NCT02914444. |
| first_indexed | 2024-03-12T13:02:31Z |
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| id | doaj.art-ae6df7ef1e3c476598f696d2da1108a4 |
| institution | Directory Open Access Journal |
| issn | 2291-9694 |
| language | English |
| last_indexed | 2024-03-12T13:02:31Z |
| publishDate | 2021-09-01 |
| publisher | JMIR Publications |
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| series | JMIR Medical Informatics |
| spelling | doaj.art-ae6df7ef1e3c476598f696d2da1108a42023-08-28T19:10:06ZengJMIR PublicationsJMIR Medical Informatics2291-96942021-09-0199e3131110.2196/31311Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model DevelopmentSooho Choehttps://orcid.org/0000-0002-7266-3853Eunjeong Parkhttps://orcid.org/0000-0003-2257-3478Wooseok Shinhttps://orcid.org/0000-0002-8475-4795Bonah Koohttps://orcid.org/0000-0002-8707-9377Dongjin Shinhttps://orcid.org/0000-0002-8122-6786Chulwoo Junghttps://orcid.org/0000-0001-7876-8659Hyungchul Leehttps://orcid.org/0000-0003-0048-7958Jeongmin Kimhttps://orcid.org/0000-0002-0468-8012 BackgroundIntraoperative hypotension has an adverse impact on postoperative outcomes. However, it is difficult to predict and treat intraoperative hypotension in advance according to individual clinical parameters. ObjectiveThe aim of this study was to develop a prediction model to forecast 5-minute intraoperative hypotension based on the weighted average ensemble of individual neural networks, utilizing the biosignals recorded during noncardiac surgery. MethodsIn this retrospective observational study, arterial waveforms were recorded during noncardiac operations performed between August 2016 and December 2019, at Seoul National University Hospital, Seoul, South Korea. We analyzed the arterial waveforms from the big data in the VitalDB repository of electronic health records. We defined 2s hypotension as the moving average of arterial pressure under 65 mmHg for 2 seconds, and intraoperative hypotensive events were defined when the 2s hypotension lasted for at least 60 seconds. We developed an artificial intelligence–enabled process, named short-term event prediction in the operating room (STEP-OP), for predicting short-term intraoperative hypotension. ResultsThe study was performed on 18,813 subjects undergoing noncardiac surgeries. Deep-learning algorithms (convolutional neural network [CNN] and recurrent neural network [RNN]) using raw waveforms as input showed greater area under the precision-recall curve (AUPRC) scores (0.698, 95% CI 0.690-0.705 and 0.706, 95% CI 0.698-0.715, respectively) than that of the logistic regression algorithm (0.673, 95% CI 0.665-0.682). STEP-OP performed better and had greater AUPRC values than those of the RNN and CNN algorithms (0.716, 95% CI 0.708-0.723). ConclusionsWe developed STEP-OP as a weighted average of deep-learning models. STEP-OP predicts intraoperative hypotension more accurately than the CNN, RNN, and logistic regression models. Trial RegistrationClinicalTrials.gov NCT02914444; https://clinicaltrials.gov/ct2/show/NCT02914444.https://medinform.jmir.org/2021/9/e31311 |
| spellingShingle | Sooho Choe Eunjeong Park Wooseok Shin Bonah Koo Dongjin Shin Chulwoo Jung Hyungchul Lee Jeongmin Kim Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development JMIR Medical Informatics |
| title | Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development |
| title_full | Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development |
| title_fullStr | Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development |
| title_full_unstemmed | Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development |
| title_short | Short-Term Event Prediction in the Operating Room (STEP-OP) of Five-Minute Intraoperative Hypotension Using Hybrid Deep Learning: Retrospective Observational Study and Model Development |
| title_sort | short term event prediction in the operating room step op of five minute intraoperative hypotension using hybrid deep learning retrospective observational study and model development |
| url | https://medinform.jmir.org/2021/9/e31311 |
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