Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator
Introduction: Rational use of platelet transfusions is one of the important treatment options available. Due to advances in apheresis technology, collection of Single Donor Platelets (SDP) with high yield is achieved. Platelet yield in the transfused SDP product influences the platelet recovery...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/15751/52932_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA2(SC_KM)_PN(KM).pdf |
| _version_ | 1818985895221526528 |
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| author | chada tejaswi venkateshwar reddy |
| author_facet | chada tejaswi venkateshwar reddy |
| author_sort | chada tejaswi |
| collection | DOAJ |
| description | Introduction: Rational use of platelet transfusions is one of the
important treatment options available. Due to advances in apheresis
technology, collection of Single Donor Platelets (SDP) with high
yield is achieved. Platelet yield in the transfused SDP product
influences the platelet recovery in the patient thus decreasing
repeated transfusions and economic burden.
Aim: To analyse donor laboratory and clinical factors influencing
the quality of SDP.
Materials and Methods: A retrospective study on plateletpheresis
procedures was conducted in the Department of Transfusion
Medicine, at Kamineni Institute of Medical Sciences Telangana,
India, from January 2017 to January 2019. A total of 168
procedures were studied which were done on intermittent flow
cell separator (Haemonetics MCS+, USA). Donor variables
such as age, gender, predonation platelet count, haemoglobin,
Haematocrit, Total Leukocyte Count (TLC), Mean Platelet
Volume (MPV), and Platelet Distribution Width (PDW) were
studied for their effect on platelet yield of SDP. Statistical
analysis was done for study of relationship between platelet
yield and donor variables using Pearson correlation.
Results: The mean age was 26.8±5.81 years with maximum in
age group 21-30 years. The mean platelet yield was 3.1±0.79×1011
per unit. Statistically significant direct correlation was observed
between predonation platelet count and platelet yield (r=0.327,
p<0.0001). No such correlation was observed with predonation
haemoglobin (r=0.098, p=0.204). There was a negative correlation
between the platelet yield and MPV (r=-0.051, p=0.512) which
was not significant. There was negative correlation between
platelet yield and PDW (r=-0.166, p=0.032) which was found to
be statistically significant. Also no statistical significance was
found between platelet yield and age of the donor (r=0.118,
p=0.125), total leukocyte count of the donor (r=0.112, p=0.147),
haematocrit of the donor (r=0.005, p=0.944).
Conclusion: Donors with higher platelet counts results in a
better yield and derives a better clinical response. This helps in
decreasing the number of transfusions per patient and exposure
to the donors thus lessening the economic burden. |
| first_indexed | 2024-12-20T18:42:10Z |
| format | Article |
| id | doaj.art-ae6e9380b62b442d80fbad5d0f09215d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-20T18:42:10Z |
| publishDate | 2021-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-ae6e9380b62b442d80fbad5d0f09215d2022-12-21T19:29:46ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-12-011512040710.7860/JCDR/2021/52932.15751Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separatorchada tejaswi 0venkateshwar reddy1Assistant Professor, Department of Transfusion Medicine, Dr. PMR Institute of Medical Sciences, Rangareddy, Telangana, IndiaAssistant Professor, Department of General Surgery, Dr. PMR Institute of Medical Sciences, Rangareddy, Telangana, India.Introduction: Rational use of platelet transfusions is one of the important treatment options available. Due to advances in apheresis technology, collection of Single Donor Platelets (SDP) with high yield is achieved. Platelet yield in the transfused SDP product influences the platelet recovery in the patient thus decreasing repeated transfusions and economic burden. Aim: To analyse donor laboratory and clinical factors influencing the quality of SDP. Materials and Methods: A retrospective study on plateletpheresis procedures was conducted in the Department of Transfusion Medicine, at Kamineni Institute of Medical Sciences Telangana, India, from January 2017 to January 2019. A total of 168 procedures were studied which were done on intermittent flow cell separator (Haemonetics MCS+, USA). Donor variables such as age, gender, predonation platelet count, haemoglobin, Haematocrit, Total Leukocyte Count (TLC), Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW) were studied for their effect on platelet yield of SDP. Statistical analysis was done for study of relationship between platelet yield and donor variables using Pearson correlation. Results: The mean age was 26.8±5.81 years with maximum in age group 21-30 years. The mean platelet yield was 3.1±0.79×1011 per unit. Statistically significant direct correlation was observed between predonation platelet count and platelet yield (r=0.327, p<0.0001). No such correlation was observed with predonation haemoglobin (r=0.098, p=0.204). There was a negative correlation between the platelet yield and MPV (r=-0.051, p=0.512) which was not significant. There was negative correlation between platelet yield and PDW (r=-0.166, p=0.032) which was found to be statistically significant. Also no statistical significance was found between platelet yield and age of the donor (r=0.118, p=0.125), total leukocyte count of the donor (r=0.112, p=0.147), haematocrit of the donor (r=0.005, p=0.944). Conclusion: Donors with higher platelet counts results in a better yield and derives a better clinical response. This helps in decreasing the number of transfusions per patient and exposure to the donors thus lessening the economic burden.https://jcdr.net/articles/PDF/15751/52932_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA2(SC_KM)_PN(KM).pdfbloodcell separatorplatelet transfusionplatelet yieldsingle donor platelets |
| spellingShingle | chada tejaswi venkateshwar reddy Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator Journal of Clinical and Diagnostic Research blood cell separator platelet transfusion platelet yield single donor platelets |
| title | Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator |
| title_full | Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator |
| title_fullStr | Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator |
| title_full_unstemmed | Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator |
| title_short | Study of Factors Affecting the Yield of Plateletpheresis by Intermittent Flow Cell Separator |
| title_sort | study of factors affecting the yield of plateletpheresis by intermittent flow cell separator |
| topic | blood cell separator platelet transfusion platelet yield single donor platelets |
| url | https://jcdr.net/articles/PDF/15751/52932_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA2(SC_KM)_PN(KM).pdf |
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