Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study
Abstract Introduction Recently, a study showing the non-inferiority of a single injection of sodium hyaluronate plus sorbitol (Synolis VA®) compared to hylan G-F20 (Synvisc-One®) over a 24-week period in patients with knee osteoarthritis was published. The objective of the present study is to assess...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2023-07-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40744-023-00573-x |
| _version_ | 1797699224484184064 |
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| author | Olivier Bruyere Germain Honvo Eduard Vidovic Bernard Cortet |
| author_facet | Olivier Bruyere Germain Honvo Eduard Vidovic Bernard Cortet |
| author_sort | Olivier Bruyere |
| collection | DOAJ |
| description | Abstract Introduction Recently, a study showing the non-inferiority of a single injection of sodium hyaluronate plus sorbitol (Synolis VA®) compared to hylan G-F20 (Synvisc-One®) over a 24-week period in patients with knee osteoarthritis was published. The objective of the present study is to assess if a short-term response to a single injection of sodium hyaluronate plus sorbitol can be maintained over a 6 month-period and if the maintenance of the response to treatment is dependent on the functional status at baseline. Methods Responders to treatment at days 28, 84, and 168 were evaluated according to the responder criteria proposed by the OMERACT-OARSI. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to assess functional status at baseline. All analyses were adjusted for age, gender, BMI, and baseline WOMAC total score using data from the intention-to-treat (ITT) population. Results Out of the 96 patients included in the study who were receiving Synolis VA®, 59.38% were responders at day 28 according to the OMERACT/OARSI responder criteria, 59.78% at day 84, and 64.52% at day 168. Among the responders at D28, the probability of being responder at D84 and D168 was significantly higher than among non-responders, with corresponding odds ratio (95% CI) of 2.85 (1.07–7.59) and 7.28 (2.53–20.93), respectively. Patients with a poorer physical function at baseline were more likely to respond to the treatment at all time points, compared to those with a better physical function (OR 3.74 [1.37–10.21]). Conclusions An early response of a single injection of sodium hyaluronate plus sorbitol is predictive of long-term response, up to 24 weeks. Patients with a poorer physical function may best benefit from the treatment. |
| first_indexed | 2024-03-12T04:04:57Z |
| format | Article |
| id | doaj.art-ae7105164b80446f8b729f59c42346ab |
| institution | Directory Open Access Journal |
| issn | 2198-6576 2198-6584 |
| language | English |
| last_indexed | 2024-03-12T04:04:57Z |
| publishDate | 2023-07-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj.art-ae7105164b80446f8b729f59c42346ab2023-09-03T11:24:42ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842023-07-011051297130310.1007/s40744-023-00573-xIs the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up StudyOlivier Bruyere0Germain Honvo1Eduard Vidovic2Bernard Cortet3WHO Collaborating Centre for Epidemiology of Musculo-Skeletal Health and Ageing, Research Unit in Public Health, Epidemiology and Health Economics, University of LiègeWHO Collaborating Centre for Epidemiology of Musculo-Skeletal Health and Ageing, Research Unit in Public Health, Epidemiology and Health Economics, University of LiègeAptissen SA Medical DepartmentDepartment of Rheumatology and UR 4490, University Hospital of LilleAbstract Introduction Recently, a study showing the non-inferiority of a single injection of sodium hyaluronate plus sorbitol (Synolis VA®) compared to hylan G-F20 (Synvisc-One®) over a 24-week period in patients with knee osteoarthritis was published. The objective of the present study is to assess if a short-term response to a single injection of sodium hyaluronate plus sorbitol can be maintained over a 6 month-period and if the maintenance of the response to treatment is dependent on the functional status at baseline. Methods Responders to treatment at days 28, 84, and 168 were evaluated according to the responder criteria proposed by the OMERACT-OARSI. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was used to assess functional status at baseline. All analyses were adjusted for age, gender, BMI, and baseline WOMAC total score using data from the intention-to-treat (ITT) population. Results Out of the 96 patients included in the study who were receiving Synolis VA®, 59.38% were responders at day 28 according to the OMERACT/OARSI responder criteria, 59.78% at day 84, and 64.52% at day 168. Among the responders at D28, the probability of being responder at D84 and D168 was significantly higher than among non-responders, with corresponding odds ratio (95% CI) of 2.85 (1.07–7.59) and 7.28 (2.53–20.93), respectively. Patients with a poorer physical function at baseline were more likely to respond to the treatment at all time points, compared to those with a better physical function (OR 3.74 [1.37–10.21]). Conclusions An early response of a single injection of sodium hyaluronate plus sorbitol is predictive of long-term response, up to 24 weeks. Patients with a poorer physical function may best benefit from the treatment.https://doi.org/10.1007/s40744-023-00573-xRespondersHyaluronic acidKnee osteoarthritisPost hoc analysis |
| spellingShingle | Olivier Bruyere Germain Honvo Eduard Vidovic Bernard Cortet Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study Rheumatology and Therapy Responders Hyaluronic acid Knee osteoarthritis Post hoc analysis |
| title | Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study |
| title_full | Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study |
| title_fullStr | Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study |
| title_full_unstemmed | Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study |
| title_short | Is the Rate of Responders to Hyaluronic Acid Injection for Patients with Knee Osteoarthritis Stable Over Time? Post hoc Analyses of a 6-Month Follow-Up Study |
| title_sort | is the rate of responders to hyaluronic acid injection for patients with knee osteoarthritis stable over time post hoc analyses of a 6 month follow up study |
| topic | Responders Hyaluronic acid Knee osteoarthritis Post hoc analysis |
| url | https://doi.org/10.1007/s40744-023-00573-x |
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