Herpes simplex virus interference with immunity: Focus on dendritic cells
Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent in the human population. These viruses cause lifelong infections by establishing latency in neurons and undergo sporadic reactivations that promote recurrent disease and new infections. The success of HSVs in persisting in i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2021.1980990 |
| _version_ | 1828125663642517504 |
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| author | Farías MA Duarte LF Tognarelli EI González PA |
| author_facet | Farías MA Duarte LF Tognarelli EI González PA |
| author_sort | Farías MA |
| collection | DOAJ |
| description | Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent in the human population. These viruses cause lifelong infections by establishing latency in neurons and undergo sporadic reactivations that promote recurrent disease and new infections. The success of HSVs in persisting in infected individuals is likely due to their multiple molecular determinants involved in escaping the host antiviral and immune responses. Importantly, HSVs infect and negatively modulate the function of dendritic cells (DCs), key immune cells that are involved in establishing effective and balanced immunity against viruses. Here, we review and discuss several molecular and cellular processes modulated by HSVs in DCs, such as autophagy, apoptosis, and the unfolded protein response. Given the central role of DCs in establishing optimal antiviral immunity, particular emphasis should be given to the outcome of the interactions occurring between HSVs and DCs. |
| first_indexed | 2024-04-11T15:23:52Z |
| format | Article |
| id | doaj.art-ae727beac49a4017be2389f12c5b3bf7 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-11T15:23:52Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-ae727beac49a4017be2389f12c5b3bf72022-12-22T04:16:18ZengTaylor & Francis GroupVirulence2150-55942150-56082021-12-011212583260710.1080/21505594.2021.19809901980990Herpes simplex virus interference with immunity: Focus on dendritic cellsFarías MA0Duarte LF1Tognarelli EI2González PA3Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de ChileHerpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are highly prevalent in the human population. These viruses cause lifelong infections by establishing latency in neurons and undergo sporadic reactivations that promote recurrent disease and new infections. The success of HSVs in persisting in infected individuals is likely due to their multiple molecular determinants involved in escaping the host antiviral and immune responses. Importantly, HSVs infect and negatively modulate the function of dendritic cells (DCs), key immune cells that are involved in establishing effective and balanced immunity against viruses. Here, we review and discuss several molecular and cellular processes modulated by HSVs in DCs, such as autophagy, apoptosis, and the unfolded protein response. Given the central role of DCs in establishing optimal antiviral immunity, particular emphasis should be given to the outcome of the interactions occurring between HSVs and DCs.http://dx.doi.org/10.1080/21505594.2021.1980990dendritic cellshsv-1hsv-2immune evasionimmunityt-cellunfolded protein response (upr)autophagyapoptosis |
| spellingShingle | Farías MA Duarte LF Tognarelli EI González PA Herpes simplex virus interference with immunity: Focus on dendritic cells Virulence dendritic cells hsv-1 hsv-2 immune evasion immunity t-cell unfolded protein response (upr) autophagy apoptosis |
| title | Herpes simplex virus interference with immunity: Focus on dendritic cells |
| title_full | Herpes simplex virus interference with immunity: Focus on dendritic cells |
| title_fullStr | Herpes simplex virus interference with immunity: Focus on dendritic cells |
| title_full_unstemmed | Herpes simplex virus interference with immunity: Focus on dendritic cells |
| title_short | Herpes simplex virus interference with immunity: Focus on dendritic cells |
| title_sort | herpes simplex virus interference with immunity focus on dendritic cells |
| topic | dendritic cells hsv-1 hsv-2 immune evasion immunity t-cell unfolded protein response (upr) autophagy apoptosis |
| url | http://dx.doi.org/10.1080/21505594.2021.1980990 |
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