Nutrition and Disorders of Gut–Brain Interaction
Background: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology that is often characterized by a relationship between food ingestion and triggering of symptoms. Understanding of the underlying mechanisms and the role of nutrients as a therapeutic target are rapidly evolving. Ai...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/176 |
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| author | Emidio Scarpellini Lukas Michaja Balsiger Bert Broeders Karen Van Den Houte Karen Routhiaux Karlien Raymenants Florencia Carbone Jan Tack |
| author_facet | Emidio Scarpellini Lukas Michaja Balsiger Bert Broeders Karen Van Den Houte Karen Routhiaux Karlien Raymenants Florencia Carbone Jan Tack |
| author_sort | Emidio Scarpellini |
| collection | DOAJ |
| description | Background: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology that is often characterized by a relationship between food ingestion and triggering of symptoms. Understanding of the underlying mechanisms and the role of nutrients as a therapeutic target are rapidly evolving. Aims and methods: We performed a narrative review of the literature using the following keywords, their acronyms, and their associations: nutrients, disorders of gut–brain interaction; functional dyspepsia; malabsorption; irritable bowel syndrome; diarrhea; constipation. Results: Functional dyspepsia displayed a significant correlation between volume, fat and/or wheat abundance, chemical composition of ingested food and symptoms of early satiety, fullness and weight loss. Carbohydrate malabsorption is related to enzyme deficiency throughout the GI tract. Food composition and richness in soluble vs. non-soluble fibers is related to constipation and diarrhea. The elimination of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) has a significant and non-unidirectional impact on irritable bowel syndrome (IBS) symptoms. Conclusions: Food volume, nutritive and chemical composition, and its malabsorption are associated with symptom generation in DGBIs. Further multicenter, randomized-controlled clinical trials are needed to clarify the underlying pathophysiology. |
| first_indexed | 2024-03-08T14:59:35Z |
| format | Article |
| id | doaj.art-ae764fe9f583465bb6b527d59c7ca8a3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T14:59:35Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ae764fe9f583465bb6b527d59c7ca8a32024-01-10T15:05:50ZengMDPI AGNutrients2072-66432024-01-0116117610.3390/nu16010176Nutrition and Disorders of Gut–Brain InteractionEmidio Scarpellini0Lukas Michaja Balsiger1Bert Broeders2Karen Van Den Houte3Karen Routhiaux4Karlien Raymenants5Florencia Carbone6Jan Tack7Translational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumTranslational Research in Gastrointestinal Disoerders (T.A.R.G.I.D.), Gasthuisberg University Hospital, KU Leuven, Herestraat 49, 3000 Lueven, BelgiumBackground: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology that is often characterized by a relationship between food ingestion and triggering of symptoms. Understanding of the underlying mechanisms and the role of nutrients as a therapeutic target are rapidly evolving. Aims and methods: We performed a narrative review of the literature using the following keywords, their acronyms, and their associations: nutrients, disorders of gut–brain interaction; functional dyspepsia; malabsorption; irritable bowel syndrome; diarrhea; constipation. Results: Functional dyspepsia displayed a significant correlation between volume, fat and/or wheat abundance, chemical composition of ingested food and symptoms of early satiety, fullness and weight loss. Carbohydrate malabsorption is related to enzyme deficiency throughout the GI tract. Food composition and richness in soluble vs. non-soluble fibers is related to constipation and diarrhea. The elimination of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) has a significant and non-unidirectional impact on irritable bowel syndrome (IBS) symptoms. Conclusions: Food volume, nutritive and chemical composition, and its malabsorption are associated with symptom generation in DGBIs. Further multicenter, randomized-controlled clinical trials are needed to clarify the underlying pathophysiology.https://www.mdpi.com/2072-6643/16/1/176nutrientsdisturbances of gut–brain axisfunctional dyspepsiamalabsorptionirritable bowel syndromediarrhea |
| spellingShingle | Emidio Scarpellini Lukas Michaja Balsiger Bert Broeders Karen Van Den Houte Karen Routhiaux Karlien Raymenants Florencia Carbone Jan Tack Nutrition and Disorders of Gut–Brain Interaction Nutrients nutrients disturbances of gut–brain axis functional dyspepsia malabsorption irritable bowel syndrome diarrhea |
| title | Nutrition and Disorders of Gut–Brain Interaction |
| title_full | Nutrition and Disorders of Gut–Brain Interaction |
| title_fullStr | Nutrition and Disorders of Gut–Brain Interaction |
| title_full_unstemmed | Nutrition and Disorders of Gut–Brain Interaction |
| title_short | Nutrition and Disorders of Gut–Brain Interaction |
| title_sort | nutrition and disorders of gut brain interaction |
| topic | nutrients disturbances of gut–brain axis functional dyspepsia malabsorption irritable bowel syndrome diarrhea |
| url | https://www.mdpi.com/2072-6643/16/1/176 |
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