Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm
Duchenne muscular dystrophy is a genetic disease that is clinically manifested by progressive muscle atrophy, followed by loss of strength, motor coordination and functional impairment. In the final stages of the disease, the patient has severe difficulty in breathing mechanics, due to the involveme...
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| Format: | Article |
| Language: | English |
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Media Med Publicis
2023-09-01
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| Series: | Modern Medicine |
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| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2023/09/Use-of-Creatine-Monohydrate-in-MDX-Mice-Morphometric-and-Stereological-Analysis-of-the-Diaphrag.pdf |
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| author | Victor Augusto Ramos FERNANDES Amilton IATECOLA Marcelo Rodrigues da CUNHA Giovanna Camarotto PATAH Dante GUARNIER João Vitor Monteiro de OLIVEIRA Maria Carolina DELFORNO Giovanna Cavalcanti BANOV Mariana SHMAYEV Julia Valencio Alves LEANDRO Kadu Ferreira Gonçalves TEIXEIRA Eduardo José CALDEIRA |
| author_facet | Victor Augusto Ramos FERNANDES Amilton IATECOLA Marcelo Rodrigues da CUNHA Giovanna Camarotto PATAH Dante GUARNIER João Vitor Monteiro de OLIVEIRA Maria Carolina DELFORNO Giovanna Cavalcanti BANOV Mariana SHMAYEV Julia Valencio Alves LEANDRO Kadu Ferreira Gonçalves TEIXEIRA Eduardo José CALDEIRA |
| author_sort | Victor Augusto Ramos FERNANDES |
| collection | DOAJ |
| description | Duchenne muscular dystrophy is a genetic disease that is clinically manifested by progressive muscle atrophy, followed by loss of strength, motor coordination and functional impairment. In the final stages of the disease, the patient has severe difficulty in breathing mechanics, due to the involvement of the muscles involved with the mechanics of breathing, including the diaphragm. The present study sought to identify the effects of creatine monohydrate supplementation in MDX mice on the morphology, morphometry and stereology of the striated muscle tissue of the diaphragm of these animals. The results indicate that, despite not influencing the increase in cell volume, supplementation acts in an anti-inflammatory way, reducing the progressive process of fibrosis that occurs in these animals in the face of muscle atrophy followed by the replacement of muscle parenchyma by connective tissue. in this way, supplementation provides a better condition for tissue maintenance, enabling more survival of MDX mice. Monohydrate creatine supplementation has been shown to be a complementary therapeutic alternative, especially for muscular dystrophies and severe myopathies. |
| first_indexed | 2024-03-11T21:42:58Z |
| format | Article |
| id | doaj.art-ae7685f752b6482b86aee272d7f7bcde |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-03-11T21:42:58Z |
| publishDate | 2023-09-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-ae7685f752b6482b86aee272d7f7bcde2023-09-26T12:46:50ZengMedia Med PublicisModern Medicine1223-04722360-24732023-09-01303191197https://doi.org/10.31689/rmm.2023.30.3.191Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the DiaphragmVictor Augusto Ramos FERNANDES0https://orcid.org/0000-0003-2861-8112Amilton IATECOLA1Marcelo Rodrigues da CUNHA2Giovanna Camarotto PATAH3https://orcid.org/0000-0002-7922-6701Dante GUARNIER4João Vitor Monteiro de OLIVEIRA5Maria Carolina DELFORNO6https://orcid.org/0000-0002-7775-1772Giovanna Cavalcanti BANOV7Mariana SHMAYEV8Julia Valencio Alves LEANDRO9Kadu Ferreira Gonçalves TEIXEIRA10Eduardo José CALDEIRA11University Nossa Senhora do Patrocínio, BrasilUniversity Nossa Senhora do Patrocínio, BrasilUniversity Nossa Senhora do Patrocínio, BrasilFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíFaculty of Medicine of JundiaíDuchenne muscular dystrophy is a genetic disease that is clinically manifested by progressive muscle atrophy, followed by loss of strength, motor coordination and functional impairment. In the final stages of the disease, the patient has severe difficulty in breathing mechanics, due to the involvement of the muscles involved with the mechanics of breathing, including the diaphragm. The present study sought to identify the effects of creatine monohydrate supplementation in MDX mice on the morphology, morphometry and stereology of the striated muscle tissue of the diaphragm of these animals. The results indicate that, despite not influencing the increase in cell volume, supplementation acts in an anti-inflammatory way, reducing the progressive process of fibrosis that occurs in these animals in the face of muscle atrophy followed by the replacement of muscle parenchyma by connective tissue. in this way, supplementation provides a better condition for tissue maintenance, enabling more survival of MDX mice. Monohydrate creatine supplementation has been shown to be a complementary therapeutic alternative, especially for muscular dystrophies and severe myopathies.https://medicinamoderna.ro/wp-content/uploads/2023/09/Use-of-Creatine-Monohydrate-in-MDX-Mice-Morphometric-and-Stereological-Analysis-of-the-Diaphrag.pdfduchenne muscular dystrophycreatine supplementationdiaphragmrespiratory musclemuscle diseases |
| spellingShingle | Victor Augusto Ramos FERNANDES Amilton IATECOLA Marcelo Rodrigues da CUNHA Giovanna Camarotto PATAH Dante GUARNIER João Vitor Monteiro de OLIVEIRA Maria Carolina DELFORNO Giovanna Cavalcanti BANOV Mariana SHMAYEV Julia Valencio Alves LEANDRO Kadu Ferreira Gonçalves TEIXEIRA Eduardo José CALDEIRA Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm Modern Medicine duchenne muscular dystrophy creatine supplementation diaphragm respiratory muscle muscle diseases |
| title | Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm |
| title_full | Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm |
| title_fullStr | Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm |
| title_full_unstemmed | Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm |
| title_short | Use of Creatine Monohydrate in MDX Mice: Morphometric and Stereological Analysis of the Diaphragm |
| title_sort | use of creatine monohydrate in mdx mice morphometric and stereological analysis of the diaphragm |
| topic | duchenne muscular dystrophy creatine supplementation diaphragm respiratory muscle muscle diseases |
| url | https://medicinamoderna.ro/wp-content/uploads/2023/09/Use-of-Creatine-Monohydrate-in-MDX-Mice-Morphometric-and-Stereological-Analysis-of-the-Diaphrag.pdf |
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