Homeostatic Regulation of Glucose Metabolism by the Central Nervous System
Evidence for involvement of the central nervous system (CNS) in the regulation of glucose metabolism dates back to the 19th century, although the majority of the research on glucose metabolism has focused on the peripheral metabolic organs. Due to recent advances in neuroscience, it has now become c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2022-02-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2021-1364.pdf |
| _version_ | 1818350328223891456 |
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| author | Jong Han Choi Min-Seon Kim |
| author_facet | Jong Han Choi Min-Seon Kim |
| author_sort | Jong Han Choi |
| collection | DOAJ |
| description | Evidence for involvement of the central nervous system (CNS) in the regulation of glucose metabolism dates back to the 19th century, although the majority of the research on glucose metabolism has focused on the peripheral metabolic organs. Due to recent advances in neuroscience, it has now become clear that the CNS is indeed vital for maintaining glucose homeostasis. To achieve normoglycemia, specific populations of neurons and glia in the hypothalamus sense changes in the blood concentrations of glucose and of glucoregulatory hormones such as insulin, leptin, glucagon-like peptide 1, and glucagon. This information is integrated and transmitted to other areas of the brain where it eventually modulates various processes in glucose metabolism (i.e., hepatic glucose production, glucose uptake in the brown adipose tissue and skeletal muscle, pancreatic insulin and glucagon secretion, renal glucose reabsorption, etc.). Errors in these processes lead to hyper- or hypoglycemia. We here review the current understanding of the brain regulation of glucose metabolism. |
| first_indexed | 2024-12-13T18:20:06Z |
| format | Article |
| id | doaj.art-ae7b044692fd4dad9fa99eb9b3a6242b |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-13T18:20:06Z |
| publishDate | 2022-02-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-ae7b044692fd4dad9fa99eb9b3a6242b2022-12-21T23:35:45ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782022-02-0137192510.3803/EnM.2021.13642263Homeostatic Regulation of Glucose Metabolism by the Central Nervous SystemJong Han Choi0Min-Seon Kim1 Division of Endocrinology and Metabolism, Konkuk University Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaEvidence for involvement of the central nervous system (CNS) in the regulation of glucose metabolism dates back to the 19th century, although the majority of the research on glucose metabolism has focused on the peripheral metabolic organs. Due to recent advances in neuroscience, it has now become clear that the CNS is indeed vital for maintaining glucose homeostasis. To achieve normoglycemia, specific populations of neurons and glia in the hypothalamus sense changes in the blood concentrations of glucose and of glucoregulatory hormones such as insulin, leptin, glucagon-like peptide 1, and glucagon. This information is integrated and transmitted to other areas of the brain where it eventually modulates various processes in glucose metabolism (i.e., hepatic glucose production, glucose uptake in the brown adipose tissue and skeletal muscle, pancreatic insulin and glucagon secretion, renal glucose reabsorption, etc.). Errors in these processes lead to hyper- or hypoglycemia. We here review the current understanding of the brain regulation of glucose metabolism.http://www.e-enm.org/upload/pdf/enm-2021-1364.pdfglucosemetabolismcentral nervous system |
| spellingShingle | Jong Han Choi Min-Seon Kim Homeostatic Regulation of Glucose Metabolism by the Central Nervous System Endocrinology and Metabolism glucose metabolism central nervous system |
| title | Homeostatic Regulation of Glucose Metabolism by the Central Nervous System |
| title_full | Homeostatic Regulation of Glucose Metabolism by the Central Nervous System |
| title_fullStr | Homeostatic Regulation of Glucose Metabolism by the Central Nervous System |
| title_full_unstemmed | Homeostatic Regulation of Glucose Metabolism by the Central Nervous System |
| title_short | Homeostatic Regulation of Glucose Metabolism by the Central Nervous System |
| title_sort | homeostatic regulation of glucose metabolism by the central nervous system |
| topic | glucose metabolism central nervous system |
| url | http://www.e-enm.org/upload/pdf/enm-2021-1364.pdf |
| work_keys_str_mv | AT jonghanchoi homeostaticregulationofglucosemetabolismbythecentralnervoussystem AT minseonkim homeostaticregulationofglucosemetabolismbythecentralnervoussystem |