Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease
Introduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be...
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MDPI AG
2023-05-01
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| author | Anderson Cesar Gonçalves Isabelle Stefan de Faria Oliveira Pedro Tadao Hamamoto Filho Erika Veruska Paiva Ortolan Simone Antunes Terra Maria Aparecida Marchesan Rodrigues Pedro Luiz Toledo de Arruda Lourenção |
| author_facet | Anderson Cesar Gonçalves Isabelle Stefan de Faria Oliveira Pedro Tadao Hamamoto Filho Erika Veruska Paiva Ortolan Simone Antunes Terra Maria Aparecida Marchesan Rodrigues Pedro Luiz Toledo de Arruda Lourenção |
| author_sort | Anderson Cesar Gonçalves |
| collection | DOAJ |
| description | Introduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be elucidated in the scientific investigation related to IND-B, which is essential for it to be considered a disease. Objective: To investigate the relationship between histopathological findings and symptoms in a series of patients with IND-B. Methods: Twenty-seven patients with histopathological diagnosis of IND-B, according to the Frankfurt Consensus (1990), who underwent surgical treatment through colorectal resections were included. Data from medical records regarding the clinical picture of the patients at the time of diagnosis, including the intestinal symptom index (ISI) and a detailed histopathological analysis of the rectal specimens, were retrieved. Exploratory factor analysis was performed, applying the principal components method for clusters with Varimax rotation. Results: Two factors were determined: the first, determined by histopathological and clinical variables, and the second, composed of the main symptoms presented in patients with IND-B, including ISI. Factorial rotation showed the association between the two factors and, through a graph, demonstrated the proximity between ISI values and histopathological alterations. Conclusion: There was evidence of an association between the clinical features presented by patients with IND-B and the histopathological findings of the rectal samples. These results support the understanding of IND-B as a disease. |
| first_indexed | 2024-03-11T03:33:45Z |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T03:33:45Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Life |
| spelling | doaj.art-ae7bfe96916840869d688be477bd016c2023-11-18T02:09:43ZengMDPI AGLife2075-17292023-05-01135117510.3390/life13051175Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a DiseaseAnderson Cesar Gonçalves0Isabelle Stefan de Faria Oliveira1Pedro Tadao Hamamoto Filho2Erika Veruska Paiva Ortolan3Simone Antunes Terra4Maria Aparecida Marchesan Rodrigues5Pedro Luiz Toledo de Arruda Lourenção6Botucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilBotucatu Medical School, São Paulo State University (UNESP), Botucatu 18618-687, BrazilIntroduction: Intestinal neuronal dysplasia type B (IND-B) is a controversial entity that affects the submucosal nerve plexus of the distal intestine. The lack of definition of the causal relationship between histological findings and clinical symptoms has been identified as the primary point to be elucidated in the scientific investigation related to IND-B, which is essential for it to be considered a disease. Objective: To investigate the relationship between histopathological findings and symptoms in a series of patients with IND-B. Methods: Twenty-seven patients with histopathological diagnosis of IND-B, according to the Frankfurt Consensus (1990), who underwent surgical treatment through colorectal resections were included. Data from medical records regarding the clinical picture of the patients at the time of diagnosis, including the intestinal symptom index (ISI) and a detailed histopathological analysis of the rectal specimens, were retrieved. Exploratory factor analysis was performed, applying the principal components method for clusters with Varimax rotation. Results: Two factors were determined: the first, determined by histopathological and clinical variables, and the second, composed of the main symptoms presented in patients with IND-B, including ISI. Factorial rotation showed the association between the two factors and, through a graph, demonstrated the proximity between ISI values and histopathological alterations. Conclusion: There was evidence of an association between the clinical features presented by patients with IND-B and the histopathological findings of the rectal samples. These results support the understanding of IND-B as a disease.https://www.mdpi.com/2075-1729/13/5/1175intestinal neuronal dysplasia type Bconstipationchildren |
| spellingShingle | Anderson Cesar Gonçalves Isabelle Stefan de Faria Oliveira Pedro Tadao Hamamoto Filho Erika Veruska Paiva Ortolan Simone Antunes Terra Maria Aparecida Marchesan Rodrigues Pedro Luiz Toledo de Arruda Lourenção Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease Life intestinal neuronal dysplasia type B constipation children |
| title | Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease |
| title_full | Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease |
| title_fullStr | Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease |
| title_full_unstemmed | Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease |
| title_short | Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease |
| title_sort | association between clinical and histopathological findings in intestinal neuronal dysplasia type b an advance towards its definition as a disease |
| topic | intestinal neuronal dysplasia type B constipation children |
| url | https://www.mdpi.com/2075-1729/13/5/1175 |
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