Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study
Background: Substantial data indicate that genetic and environmental factors play a key role in determining the risk of Alzheimer’s disease (AD). Moreover, it is known that having relatives with AD increases the risk of developing this disease.Objective: This study is aimed at investigating whether...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2023-08-01
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| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | https://jbpe.sums.ac.ir/article_47694_a7084ef9c6f5d44ed28e60ca1ac47884.pdf |
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| author | Seyed Jalil Masoumi Masoud Haghani Pooneh Mokkaram Donya Firoozi Seyed Ali Reza Mortazavi Fariba Moradi Ardekani Atefeh Torabi Ardakani Seyed Mohammad Javad Mortazavi |
| author_facet | Seyed Jalil Masoumi Masoud Haghani Pooneh Mokkaram Donya Firoozi Seyed Ali Reza Mortazavi Fariba Moradi Ardekani Atefeh Torabi Ardakani Seyed Mohammad Javad Mortazavi |
| author_sort | Seyed Jalil Masoumi |
| collection | DOAJ |
| description | Background: Substantial data indicate that genetic and environmental factors play a key role in determining the risk of Alzheimer’s disease (AD). Moreover, it is known that having relatives with AD increases the risk of developing this disease.Objective: This study is aimed at investigating whether having a family history of AD, may increase the risk of COVID-19 in a cohort-based study.Material and Methods: Participants of this retrospective cohort study were previously enrolled in the SUMS Employees Cohort (SUMSEC). All participants including those whose SARS-CoV-2 infection was confirmed by positive PCR test and chest CT scan were requested to respond to interviewer-administered questionnaires. Moreover, AD was diagnosed via memory and thinking impairment, concentration problems, confusion with location, and problems in finishing daily tasks.Results: The total numbers of female and male participants with a family history of AD were 463 and 222 individuals, respectively. When all types of family history of AD were considered, a 51.3% increase was found in the relative frequency of the participants with both family history of AD and confirmed COVID-19 compared with those only with a family history of AD. Conclusion: Despite the limitations of our study, and from a broader perspective, our findings can further support the concept that AD risk haplotypes including APOE are linked to the same morbidities from cardiovascular disease and obesity that increase vulnerability to COVID-19. Given this consideration, millions of APOE ε4 carriers around the globe should be advised to take additional precautions to prevent life-threatening diseases such as COVID-19. |
| first_indexed | 2024-03-12T14:40:21Z |
| format | Article |
| id | doaj.art-ae7c6753d94a45e3ae37421defb794bf |
| institution | Directory Open Access Journal |
| issn | 2251-7200 |
| language | English |
| last_indexed | 2024-03-12T14:40:21Z |
| publishDate | 2023-08-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Biomedical Physics and Engineering |
| spelling | doaj.art-ae7c6753d94a45e3ae37421defb794bf2023-08-16T09:11:26ZengShiraz University of Medical SciencesJournal of Biomedical Physics and Engineering2251-72002023-08-0113436336610.31661/jbpe.v0i0.2104-131847694Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based StudySeyed Jalil Masoumi0Masoud Haghani1Pooneh Mokkaram2Donya Firoozi3Seyed Ali Reza Mortazavi4Fariba Moradi Ardekani5Atefeh Torabi Ardakani6Seyed Mohammad Javad Mortazavi7Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Science, Shiraz, IranDepartment of Radiology, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Biochemistry, Autophagy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranSchool of Medicine, Shiraz University of Medical Sciences, Shiraz, IranCenter for Cohort Study of SUMS Employees’ Health, Shiraz University of Medical Sciences, Shiraz, IranCenter for Cohort Study of SUMS Employees’ Health, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Physics and Engineering, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackground: Substantial data indicate that genetic and environmental factors play a key role in determining the risk of Alzheimer’s disease (AD). Moreover, it is known that having relatives with AD increases the risk of developing this disease.Objective: This study is aimed at investigating whether having a family history of AD, may increase the risk of COVID-19 in a cohort-based study.Material and Methods: Participants of this retrospective cohort study were previously enrolled in the SUMS Employees Cohort (SUMSEC). All participants including those whose SARS-CoV-2 infection was confirmed by positive PCR test and chest CT scan were requested to respond to interviewer-administered questionnaires. Moreover, AD was diagnosed via memory and thinking impairment, concentration problems, confusion with location, and problems in finishing daily tasks.Results: The total numbers of female and male participants with a family history of AD were 463 and 222 individuals, respectively. When all types of family history of AD were considered, a 51.3% increase was found in the relative frequency of the participants with both family history of AD and confirmed COVID-19 compared with those only with a family history of AD. Conclusion: Despite the limitations of our study, and from a broader perspective, our findings can further support the concept that AD risk haplotypes including APOE are linked to the same morbidities from cardiovascular disease and obesity that increase vulnerability to COVID-19. Given this consideration, millions of APOE ε4 carriers around the globe should be advised to take additional precautions to prevent life-threatening diseases such as COVID-19.https://jbpe.sums.ac.ir/article_47694_a7084ef9c6f5d44ed28e60ca1ac47884.pdfalzheimer’s diseaseapoe4 genesars-cov-2covid-19 |
| spellingShingle | Seyed Jalil Masoumi Masoud Haghani Pooneh Mokkaram Donya Firoozi Seyed Ali Reza Mortazavi Fariba Moradi Ardekani Atefeh Torabi Ardakani Seyed Mohammad Javad Mortazavi Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study Journal of Biomedical Physics and Engineering alzheimer’s disease apoe4 gene sars-cov-2 covid-19 |
| title | Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study |
| title_full | Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study |
| title_fullStr | Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study |
| title_full_unstemmed | Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study |
| title_short | Family History of Alzheimer’s Disease Increases the Risk of COVID-19 Positivity: A SUMS Employees Cohort-based Study |
| title_sort | family history of alzheimer s disease increases the risk of covid 19 positivity a sums employees cohort based study |
| topic | alzheimer’s disease apoe4 gene sars-cov-2 covid-19 |
| url | https://jbpe.sums.ac.ir/article_47694_a7084ef9c6f5d44ed28e60ca1ac47884.pdf |
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