The role of B cells in cancer development
B cells play a critical role in adaptive immune responses mainly due to antigen presentation and antibody production. Studies about the tumor-infiltrating immune cells so far demonstrated that the function of B cells in tumor immunity is quite different among various tumor types. The antigen present...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.958756/full |
| _version_ | 1811217225258893312 |
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| author | Rongying Tan Rongying Tan Manhua Nie Manhua Nie Wang Long |
| author_facet | Rongying Tan Rongying Tan Manhua Nie Manhua Nie Wang Long |
| author_sort | Rongying Tan |
| collection | DOAJ |
| description | B cells play a critical role in adaptive immune responses mainly due to antigen presentation and antibody production. Studies about the tumor-infiltrating immune cells so far demonstrated that the function of B cells in tumor immunity is quite different among various tumor types. The antigen presentation of B cells is mainly anti-tumoral, while the role of antibody production is controversial. Moreover, the immunosuppressive regulatory B cells are detrimental to anti-tumor immunity via the secretion of various anti-inflammatory cytokines. This review briefly summarizes the different roles of B cells classified by the primary function of B cells, antigen presentation, antibody production, and immunity regulation. Further, it discusses the potential therapeutic target of B cells in tumor immunity. |
| first_indexed | 2024-04-12T06:51:49Z |
| format | Article |
| id | doaj.art-ae7c7c15f5474c23b00490342536e074 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T06:51:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ae7c7c15f5474c23b00490342536e0742022-12-22T03:43:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.958756958756The role of B cells in cancer developmentRongying Tan0Rongying Tan1Manhua Nie2Manhua Nie3Wang Long4Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, ChinaClinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Pathology, Nihon University, Tokyo, JapanB cells play a critical role in adaptive immune responses mainly due to antigen presentation and antibody production. Studies about the tumor-infiltrating immune cells so far demonstrated that the function of B cells in tumor immunity is quite different among various tumor types. The antigen presentation of B cells is mainly anti-tumoral, while the role of antibody production is controversial. Moreover, the immunosuppressive regulatory B cells are detrimental to anti-tumor immunity via the secretion of various anti-inflammatory cytokines. This review briefly summarizes the different roles of B cells classified by the primary function of B cells, antigen presentation, antibody production, and immunity regulation. Further, it discusses the potential therapeutic target of B cells in tumor immunity.https://www.frontiersin.org/articles/10.3389/fonc.2022.958756/fullB celltumortumor immunitycancerimmunotherapytumor microenvironment |
| spellingShingle | Rongying Tan Rongying Tan Manhua Nie Manhua Nie Wang Long The role of B cells in cancer development Frontiers in Oncology B cell tumor tumor immunity cancer immunotherapy tumor microenvironment |
| title | The role of B cells in cancer development |
| title_full | The role of B cells in cancer development |
| title_fullStr | The role of B cells in cancer development |
| title_full_unstemmed | The role of B cells in cancer development |
| title_short | The role of B cells in cancer development |
| title_sort | role of b cells in cancer development |
| topic | B cell tumor tumor immunity cancer immunotherapy tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.958756/full |
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