Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation
Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-03-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.664334/full |
| _version_ | 1818847051302043648 |
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| author | Yuntao Lu Bing Liu Junjie Ma Shuo Yang Ju Huang Ju Huang |
| author_facet | Yuntao Lu Bing Liu Junjie Ma Shuo Yang Ju Huang Ju Huang |
| author_sort | Yuntao Lu |
| collection | DOAJ |
| description | Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadian expression of approximately 3,000 genes. We found that circadian rhythm disappears in genes related to metabolism and signaling pathways regulating protein phosphorylation after acute sleep deprivation, while the core circadian regulators do not change much in rhythmicity. Importantly, the strong positive correlation between mean expression and amplitude (E-A correlation) of cycling genes has been validated in both control and sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression. Thus, we reveal that acute sleep deprivation leads to a profound change in the circadian gene transcription that influences the biological functions in lung. |
| first_indexed | 2024-12-19T05:55:18Z |
| format | Article |
| id | doaj.art-ae7cef76154a41ae9fa44a3c8c6f1bf4 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-19T05:55:18Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-ae7cef76154a41ae9fa44a3c8c6f1bf42022-12-21T20:33:28ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-03-011210.3389/fgene.2021.664334664334Disruption of Circadian Transcriptome in Lung by Acute Sleep DeprivationYuntao Lu0Bing Liu1Junjie Ma2Shuo Yang3Ju Huang4Ju Huang5Department of Pulmonary and Critical Care Medicine, Huadong Hospital, Fudan University, Shanghai, ChinaCenter for Brain Science, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, ChinaCenter for Brain Science, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCenter for Brain Science, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadian expression of approximately 3,000 genes. We found that circadian rhythm disappears in genes related to metabolism and signaling pathways regulating protein phosphorylation after acute sleep deprivation, while the core circadian regulators do not change much in rhythmicity. Importantly, the strong positive correlation between mean expression and amplitude (E-A correlation) of cycling genes has been validated in both control and sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression. Thus, we reveal that acute sleep deprivation leads to a profound change in the circadian gene transcription that influences the biological functions in lung.https://www.frontiersin.org/articles/10.3389/fgene.2021.664334/fullcircadian clocklungcircadian transcriptomesleep deprivationenergetic cost |
| spellingShingle | Yuntao Lu Bing Liu Junjie Ma Shuo Yang Ju Huang Ju Huang Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation Frontiers in Genetics circadian clock lung circadian transcriptome sleep deprivation energetic cost |
| title | Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation |
| title_full | Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation |
| title_fullStr | Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation |
| title_full_unstemmed | Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation |
| title_short | Disruption of Circadian Transcriptome in Lung by Acute Sleep Deprivation |
| title_sort | disruption of circadian transcriptome in lung by acute sleep deprivation |
| topic | circadian clock lung circadian transcriptome sleep deprivation energetic cost |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.664334/full |
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