Orbital retinoblastoma: An update
Orbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=6;spage=435;epage=442;aulast=Honavar |
| _version_ | 1818241877695004672 |
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| author | Santosh G Honavar Fairooz P Manjandavida Vijay Anand P Reddy |
| author_facet | Santosh G Honavar Fairooz P Manjandavida Vijay Anand P Reddy |
| author_sort | Santosh G Honavar |
| collection | DOAJ |
| description | Orbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality as high as 70%. The recent understanding on the role of sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve life salvage. |
| first_indexed | 2024-12-12T13:36:19Z |
| format | Article |
| id | doaj.art-ae80204e390e4fefac8d5557a1cde59f |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-12T13:36:19Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-ae80204e390e4fefac8d5557a1cde59f2022-12-22T00:22:57ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892017-01-0165643544210.4103/ijo.IJO_352_15Orbital retinoblastoma: An updateSantosh G HonavarFairooz P ManjandavidaVijay Anand P ReddyOrbital extension is a major cause of death in children with retinoblastoma in the developing countries. Delayed detection and inappropriate management contribute to poor outcome. Conventional treatment including primary orbital exenteration or chemotherapy or radiotherapy alone result in mortality as high as 70%. The recent understanding on the role of sequential multimodal therapy with a combination of high-dose chemotherapy, followed by appropriate surgery, radiotherapy, and additional adjuvant chemotherapy has helped dramatically improve life salvage.http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=6;spage=435;epage=442;aulast=HonavarMultimodal therapyorbitretinoblastoma |
| spellingShingle | Santosh G Honavar Fairooz P Manjandavida Vijay Anand P Reddy Orbital retinoblastoma: An update Indian Journal of Ophthalmology Multimodal therapy orbit retinoblastoma |
| title | Orbital retinoblastoma: An update |
| title_full | Orbital retinoblastoma: An update |
| title_fullStr | Orbital retinoblastoma: An update |
| title_full_unstemmed | Orbital retinoblastoma: An update |
| title_short | Orbital retinoblastoma: An update |
| title_sort | orbital retinoblastoma an update |
| topic | Multimodal therapy orbit retinoblastoma |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2017;volume=65;issue=6;spage=435;epage=442;aulast=Honavar |
| work_keys_str_mv | AT santoshghonavar orbitalretinoblastomaanupdate AT fairoozpmanjandavida orbitalretinoblastomaanupdate AT vijayanandpreddy orbitalretinoblastomaanupdate |