Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors
Objective: To investigate prolonged neurological impacts of COVID-19 and establish a connection between initial COVID-19 symptom severity and chronic fatigue syndrome (CFS) development, poor sleep quality (PSQ), and cognitive impairment (CI) in individuals recovered from COVID-19. Methods: This cr...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Padjadjaran
2023-09-01
|
| Series: | International Journal of Integrated Health Sciences |
| Subjects: | |
| Online Access: | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3215 |
| _version_ | 1797449306121175040 |
|---|---|
| author | Ahmad Rizal Ganiem Siuliyanty Siuliyanty Anam Ong Uni Gamayani Lisda Amalia Yusuf Wibisono |
| author_facet | Ahmad Rizal Ganiem Siuliyanty Siuliyanty Anam Ong Uni Gamayani Lisda Amalia Yusuf Wibisono |
| author_sort | Ahmad Rizal Ganiem |
| collection | DOAJ |
| description | Objective: To investigate prolonged neurological impacts of COVID-19 and establish a connection between initial COVID-19 symptom severity and chronic fatigue syndrome (CFS) development, poor sleep quality (PSQ), and cognitive impairment (CI) in individuals recovered from COVID-19.
Methods: This cross-sectional study recruited COVID-19 survivors at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between June and December 2021. All participants gave informed consent and underwent interviews on demography, clinical features, long-COVID questionnaire, and neurological examination. Participants underwent cognitive examination (MOCA-INA), Chalder Fatigue Scale and Pittsburgh Sleep Quality Index (PSQI) to assess CI, CFS, and PSQ variables. Chi-Square analysis was performed to determine the probability of neurological long COVID-19 syndrome manifestations using SPSS 24.0.
Results: Of the 127 participants recruited, 67.7% were women, median (IQR) age of 33 (21-65) years, and time from hospitalization to examination of nine months (1-13). The most common neurological Long COVID symptoms were PSQ (59.8. %), CFS (51.2%), and CI (33.9%). Participants with more than five acute phase COVID-19 symptoms had a higher probability of CFS and CI (OR 2.38 (1, 16-4.9, CI 95%); OR 2.20 (1.01-4.79, CI 95%)) than those with less than five symptoms. The study did not find a significant correlation between sleep quality and number of acute-phase COVID-19 symptoms (OR 1.56 (0.76-3.20, CI 95%)).
Conclusion: Almost two-thirds of the COVID-19 survivors experienced PSQ, more than half had CFS, and almost one-third had CI. The study revealed an increasing likelihood of CFS and CI in COVID-19 survivors as the number of acute COVID-19 symptoms increases. |
| first_indexed | 2024-03-09T14:23:02Z |
| format | Article |
| id | doaj.art-ae81ad87e5294475bd5acebbff7cae36 |
| institution | Directory Open Access Journal |
| issn | 2302-1381 2338-4506 |
| language | English |
| last_indexed | 2024-03-09T14:23:02Z |
| publishDate | 2023-09-01 |
| publisher | Universitas Padjadjaran |
| record_format | Article |
| series | International Journal of Integrated Health Sciences |
| spelling | doaj.art-ae81ad87e5294475bd5acebbff7cae362023-11-28T09:18:09ZengUniversitas PadjadjaranInternational Journal of Integrated Health Sciences2302-13812338-45062023-09-0111211211910.15850/ijihs.v11n2.32151637Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 SurvivorsAhmad Rizal Ganiem0Siuliyanty Siuliyanty1Anam Ong2Uni Gamayani3Lisda Amalia4Yusuf Wibisono5Department of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungDepartment of Neurology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital BandungObjective: To investigate prolonged neurological impacts of COVID-19 and establish a connection between initial COVID-19 symptom severity and chronic fatigue syndrome (CFS) development, poor sleep quality (PSQ), and cognitive impairment (CI) in individuals recovered from COVID-19. Methods: This cross-sectional study recruited COVID-19 survivors at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between June and December 2021. All participants gave informed consent and underwent interviews on demography, clinical features, long-COVID questionnaire, and neurological examination. Participants underwent cognitive examination (MOCA-INA), Chalder Fatigue Scale and Pittsburgh Sleep Quality Index (PSQI) to assess CI, CFS, and PSQ variables. Chi-Square analysis was performed to determine the probability of neurological long COVID-19 syndrome manifestations using SPSS 24.0. Results: Of the 127 participants recruited, 67.7% were women, median (IQR) age of 33 (21-65) years, and time from hospitalization to examination of nine months (1-13). The most common neurological Long COVID symptoms were PSQ (59.8. %), CFS (51.2%), and CI (33.9%). Participants with more than five acute phase COVID-19 symptoms had a higher probability of CFS and CI (OR 2.38 (1, 16-4.9, CI 95%); OR 2.20 (1.01-4.79, CI 95%)) than those with less than five symptoms. The study did not find a significant correlation between sleep quality and number of acute-phase COVID-19 symptoms (OR 1.56 (0.76-3.20, CI 95%)). Conclusion: Almost two-thirds of the COVID-19 survivors experienced PSQ, more than half had CFS, and almost one-third had CI. The study revealed an increasing likelihood of CFS and CI in COVID-19 survivors as the number of acute COVID-19 symptoms increases.https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3215chronic fatigue syndromecognitive impairmentlong covidpoor sleep quality |
| spellingShingle | Ahmad Rizal Ganiem Siuliyanty Siuliyanty Anam Ong Uni Gamayani Lisda Amalia Yusuf Wibisono Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors International Journal of Integrated Health Sciences chronic fatigue syndrome cognitive impairment long covid poor sleep quality |
| title | Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors |
| title_full | Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors |
| title_fullStr | Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors |
| title_full_unstemmed | Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors |
| title_short | Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors |
| title_sort | correlation between acute phase symptoms with neurological long covid symptoms on covid 19 survivors |
| topic | chronic fatigue syndrome cognitive impairment long covid poor sleep quality |
| url | https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3215 |
| work_keys_str_mv | AT ahmadrizalganiem correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors AT siuliyantysiuliyanty correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors AT anamong correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors AT unigamayani correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors AT lisdaamalia correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors AT yusufwibisono correlationbetweenacutephasesymptomswithneurologicallongcovidsymptomsoncovid19survivors |