Role of functional pharmacological therapy in post-stroke depression: a narrative review

Objective We conducted a narrative review to investigate whether antidepressant therapy, including the use of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) or the use of supportive drugs (i.e., citicoline or choline alfoscerate) as a substitu...

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Main Authors: Francesco Corallo, Chiara Scarfì, Francesca Antonia Arcadi, Caterina Formica, Marcella Di Cara, Rosanna Palmeri, Laura Romeo, Viviana Lo Buono, Placido Bramanti, Silvia Marino, Maria Cristina De Cola
Format: Article
Language:English
Published: SAGE Publishing 2020-10-01
Series:Journal of International Medical Research
Online Access:https://doi.org/10.1177/0300060520950557
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author Francesco Corallo
Chiara Scarfì
Francesca Antonia Arcadi
Caterina Formica
Marcella Di Cara
Rosanna Palmeri
Laura Romeo
Viviana Lo Buono
Placido Bramanti
Silvia Marino
Maria Cristina De Cola
author_facet Francesco Corallo
Chiara Scarfì
Francesca Antonia Arcadi
Caterina Formica
Marcella Di Cara
Rosanna Palmeri
Laura Romeo
Viviana Lo Buono
Placido Bramanti
Silvia Marino
Maria Cristina De Cola
author_sort Francesco Corallo
collection DOAJ
description Objective We conducted a narrative review to investigate whether antidepressant therapy, including the use of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) or the use of supportive drugs (i.e., citicoline or choline alfoscerate) as a substitute for antidepressant therapy, reduces depression in patients with cerebrovascular diseases. Methods A systematic search of the PubMed and Web of Science databases was performed, including review articles and other studies to identify additional citations. Only 4 of 1566 publications met the inclusion/exclusion criteria and were selected. Results Studies showed that post-stroke depression (PSD) could be treated with antidepressant therapy, as well as supportive drugs such as citicoline or choline alfoscerate, which may have antidepressant effects. Conclusions The findings support the efficacy of citicoline as a treatment for depression. Studies aimed to discover the characteristics of these psychostimulants in relation to PSD treatment should be performed.
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spelling doaj.art-ae830bae301d453097459f00d3486c4e2022-12-21T20:08:33ZengSAGE PublishingJournal of International Medical Research1473-23002020-10-014810.1177/0300060520950557Role of functional pharmacological therapy in post-stroke depression: a narrative reviewFrancesco CoralloChiara ScarfìFrancesca Antonia ArcadiCaterina FormicaMarcella Di CaraRosanna PalmeriLaura RomeoViviana Lo BuonoPlacido BramantiSilvia MarinoMaria Cristina De ColaObjective We conducted a narrative review to investigate whether antidepressant therapy, including the use of selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) or the use of supportive drugs (i.e., citicoline or choline alfoscerate) as a substitute for antidepressant therapy, reduces depression in patients with cerebrovascular diseases. Methods A systematic search of the PubMed and Web of Science databases was performed, including review articles and other studies to identify additional citations. Only 4 of 1566 publications met the inclusion/exclusion criteria and were selected. Results Studies showed that post-stroke depression (PSD) could be treated with antidepressant therapy, as well as supportive drugs such as citicoline or choline alfoscerate, which may have antidepressant effects. Conclusions The findings support the efficacy of citicoline as a treatment for depression. Studies aimed to discover the characteristics of these psychostimulants in relation to PSD treatment should be performed.https://doi.org/10.1177/0300060520950557
spellingShingle Francesco Corallo
Chiara Scarfì
Francesca Antonia Arcadi
Caterina Formica
Marcella Di Cara
Rosanna Palmeri
Laura Romeo
Viviana Lo Buono
Placido Bramanti
Silvia Marino
Maria Cristina De Cola
Role of functional pharmacological therapy in post-stroke depression: a narrative review
Journal of International Medical Research
title Role of functional pharmacological therapy in post-stroke depression: a narrative review
title_full Role of functional pharmacological therapy in post-stroke depression: a narrative review
title_fullStr Role of functional pharmacological therapy in post-stroke depression: a narrative review
title_full_unstemmed Role of functional pharmacological therapy in post-stroke depression: a narrative review
title_short Role of functional pharmacological therapy in post-stroke depression: a narrative review
title_sort role of functional pharmacological therapy in post stroke depression a narrative review
url https://doi.org/10.1177/0300060520950557
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