Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/1/147 |
| _version_ | 1797446844318482432 |
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| author | Gabriele Serreli Monica Deiana |
| author_facet | Gabriele Serreli Monica Deiana |
| author_sort | Gabriele Serreli |
| collection | DOAJ |
| description | Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and neuronal nitric oxide synthase (nNOS). The expression and activity of these isoforms depends on the activation/deactivation of different signaling pathways at an intracellular level following different physiological and pathological stimuli. Compounds of natural origin such as polyphenols, which are obtainable through diet, have been widely studied in recent years in in vivo and in vitro investigations for their ability to induce or inhibit NO release, depending on the tissue. In this review, we aim to disclose the scientific evidence relating to the activity of the main dietary polyphenols in the modulation of the intracellular pathways involved in the expression and/or functionality of the NOS isoforms. |
| first_indexed | 2024-03-09T13:46:27Z |
| format | Article |
| id | doaj.art-ae86227e8d5a41b591591bfd751ef172 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T13:46:27Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-ae86227e8d5a41b591591bfd751ef1722023-11-30T20:58:58ZengMDPI AGAntioxidants2076-39212023-01-0112114710.3390/antiox12010147Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A ReviewGabriele Serreli0Monica Deiana1Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, ItalyDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, ItalyNitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually released in numerous organs and tissues. There are mainly three isoforms of the enzyme that produce NO starting from the metabolism of arginine, namely endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), and neuronal nitric oxide synthase (nNOS). The expression and activity of these isoforms depends on the activation/deactivation of different signaling pathways at an intracellular level following different physiological and pathological stimuli. Compounds of natural origin such as polyphenols, which are obtainable through diet, have been widely studied in recent years in in vivo and in vitro investigations for their ability to induce or inhibit NO release, depending on the tissue. In this review, we aim to disclose the scientific evidence relating to the activity of the main dietary polyphenols in the modulation of the intracellular pathways involved in the expression and/or functionality of the NOS isoforms.https://www.mdpi.com/2076-3921/12/1/147mechanisms of actionnitric oxidenitric oxide synthasepolyphenolssignaling pathways |
| spellingShingle | Gabriele Serreli Monica Deiana Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review Antioxidants mechanisms of action nitric oxide nitric oxide synthase polyphenols signaling pathways |
| title | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
| title_full | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
| title_fullStr | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
| title_full_unstemmed | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
| title_short | Role of Dietary Polyphenols in the Activity and Expression of Nitric Oxide Synthases: A Review |
| title_sort | role of dietary polyphenols in the activity and expression of nitric oxide synthases a review |
| topic | mechanisms of action nitric oxide nitric oxide synthase polyphenols signaling pathways |
| url | https://www.mdpi.com/2076-3921/12/1/147 |
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